A5077780687- interferon and immune responses
- RNA regulation and disease
- Hippo pathway signaling and YAP/TAZ
- Viral Infections and Vectors
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Immune cells in cancer
- Coronary Artery Anomalies
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Pulmonary Hypertension Research and Treatments
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Lipid metabolism and biosynthesis
- Fibroblast Growth Factor Research
- Kawasaki Disease and Coronary Complications
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
Zhejiang Lab
2022-2024
Zhejiang University
2016-2024
First Affiliated Hospital of Anhui Medical University
2009-2021
Anhui Medical University
2006-2021
First Affiliated Hospital Zhejiang University
2021
Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy, biased mRNA translation, and interferon-mediated immune responses. However, detailed mechanisms physiological relevance STING-induced senescence are not fully understood. Here, we unexpectedly found that interferon regulatory factor 3 (IRF3), activated during innate sensing, forms substantial endogenous complexes in the nucleus...
Cytosolic RNA/DNA sensing elicits primary defense against viral pathogens. Interferon regulatory factor 3 (IRF3), a key signal mediator/transcriptional of the antiviral-sensing pathway, is indispensible for interferon production and antiviral defense. However, how status IRF3 activation controlled remains elusive. Through functional screen human kinome, we found that mammalian sterile 20-like kinase 1 (Mst1), but not Mst2, profoundly inhibited cytosolic nucleic acid sensing. Mst1 associated...
Intratumoral glucose availability links considerably to tumor growth, immune evasion, and metastasis. However, the precise mechanisms by which levels govern cellular responses remain incompletely understood. Here, we explored intersections between AMP-activated protein kinase (AMPK) cGAS-STING signaling, a key pathway initiating antitumor immunity. We unexpectedly found that AMPK activation robustly enhances signaling within cancer cells, potently impacts melanoma colorectal cell senescence,...
The Hippo-YAP pathway responds to diverse environmental cues manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) determine its physiological activity are still inconclusive. Here, we utilized an unbiased phosphatome screening identified phosphatase magnesium-dependent 1A (PPM1A/PP2Cα) as the bona fide YAP phosphatase. We found that PPM1A was associated with YAP/TAZ in both cytoplasm nucleus...
Abstract Mechanical control is fundamental for cellular localization within a tissue, including tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact pathogenesis therapeutics of malignant diseases, their effects on cell residency motility remain incompletely understood. Here, we uncovered that TBK1 kinase, activated by or signaling in macrophages, directly phosphorylates mobilizes Zyxin, key regulator actin dynamics. Under pathological...
Doppler tissue imaging analysis was used to examine the relationship between right ventricular function and outflow tract damage in 54 patients with repaired tetralogy of Fallot. The were divided into three groups: 16 whom directly sutured (group DS), 23 who had transventricular patch repair TVP), 15 transannular TAP). control group consisted age-matched underwent closure a septal defect C). Tei index obtained from tricuspid pulmonary flow velocities. significantly greater groups TVP TAP...
目的 探讨医院-社区-患者三级规范化管理对冠心病患者生存质量、生活习惯、用药依从性及预后的影响。 方法 将我院下属4个社区的所有行冠状动脉旁路移植术(CABG)或经皮冠状动脉介入治疗(PCI)的207例患者，按随机区组设计分为管理组和对照组。其中2个社区为管理组，对其社区医生进行培训，同时对其所在社区冠心病术后患者进行规范管理，另2个社区不进行医师培训和患者管理，作为对照组。对比两组患者的生存质量、生活习惯、用药依从性及预后。 结果 管理组患者通过医院与社区联合规范化管理后，心率、血压、血脂、体质指数等相关指标控制均比对照组好(均为P<0.05)；同时，与对照组相比，管理组患者在低盐低脂饮食、合理休息、适当运动、戒烟戒酒等生活行为方面有所改善(均为P<0.05)；两者在用药依从性方面，管理组(90.2%)明显优于对照组(55.8%，P＝0.007)；管理组患者的心原性死亡率(4.5%)较对照组低(8.4%，P＝0.029)。 结论 通过医院与社区联合规范化管理冠心病术后患者，建立冠心病三级规范化管理体系，集医院-社区-患者于一体，能够提高冠心...