A5101511317- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Liver physiology and pathology
- Biochemical effects in animals
- Phagocytosis and Immune Regulation
- DNA Repair Mechanisms
- Mathematical Biology Tumor Growth
- Organ Transplantation Techniques and Outcomes
- Pain Mechanisms and Treatments
- Cell Image Analysis Techniques
- Pharmacological Receptor Mechanisms and Effects
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Acute Myeloid Leukemia Research
- Gene Regulatory Network Analysis
- Mesenchymal stem cell research
- Microtubule and mitosis dynamics
- Chromosomal and Genetic Variations
- Hydrogen's biological and therapeutic effects
- RNA modifications and cancer
First Affiliated Hospital Zhejiang University
2020-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Zhejiang University
2016-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2023-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Zhejiang Chinese Medical University
2023
National Institutes of Health
2019
National Cancer Institute
2019
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a kind of tumor lacking nutrients due to its poor vascularity and desmoplasia. Recent studies have shown that cancer cells might achieve growth advantage through epitranscriptome reprogramming. However, the role m 5 C in PDAC was not fully understood. We found Aly/REF export factor (ALYREF), reader modification, overexpressed PDAC, associated with bad prognosis. In addition, ALYREF expression negatively related CD8 + T infiltration clinical...
Abstract Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma. Menstrual blood‐derived mesenchymal stem cells (MenSCs) ameliorate liver through paracrine. Single‐cell RNA sequencing (scRNA‐seq) may be used to explore the roadmap of activated hepatic stellate cell (aHSC) inactivation target fibrosis. This study established HBV transgenic (HBV‐Tg) mouse model carbon tetrachloride (CCl 4 )‐induced and demonstrated that MenSCs migrated injured improve serological...
Human menstrual blood-derived mesenchymal stem cells (MenSCs) and their secreted small extracellular vesicles (EVs) had been proven to relieve inflammation, tissue damage, fibrosis in various organs. The microenvironment induced by inflammatory cytokines can promote (MSCs) secrete more substances (including EVs) that could regulate inflammation. Inflammatory bowel disease (IBD) is a chronic idiopathic intestinal the etiology mechanism of which are unclear. At present, existing therapeutic...
With the aim to reduce antigenicity of whey protein hydrolysate in milk, pretreatment method coupling ultrasonic and ionic liquid (US-IL) further enzymatic treatments were studied. Papain alcalase found be suitable for ultrasonic-ionic pretreatment. After ultrasound-ionic treatment, antigenic decline rates ALA BLG upon hydrolysis 82.82% 88.01%, that papain was 81.87% 88.46%, respectively. Upon pretreatment, molecular weight did not change significantly, but small proportion components...
Abstract Kinesin family member 11 (KIF11) is a plus end‐directed kinesin indispensable for the formation of bipolar spindle in metaphase, where it objects to action minus molecular motors. Here, we hypothesize that KIF11 might be therapeutic target breast cancer and regulated by miR‐30a . Cell Counting Kit 8 assays were used investigate cell proliferation. Invasion survey motility cells. Kaplan‐Meier Cox proportional analyses employed this outcome study. The prognostic significance...
As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects-including anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism-without the psychoactive side effects induced by CB1R activation, they have become focus research development new target drugs in recent years. The present study was intended to (1) establish a double luciferase screening system for CB2R modulator; (2) validate agonistic activities screened compounds on determining...
Mesenchymal stem cells (MSCs) have been used in liver transplantation and certain effects alleviating ischemia-reperfusion injury (IRI) regulating immune rejection. However, some studies indicated that the of MSCs are not very significant. Therefore, approaches enable to exert significant stable therapeutic worth further study.To enhance potential human menstrual blood-derived stromal (MenSCs) mouse (I/R) model via interferon-γ (IFN-γ) priming.Apoptosis was analyzed by flow cytometry...
Pituitary adenomas are common brain tumors. Although transsphenoidal surgery able to achieve extensive tumor removal, the rate of recurrence ranges from 5 20% depending on different subtype. Further understanding these tumors is needed develop novel strategies improve prognosis patients. But their metabolic characteristics largely unknown. We used metabolomic, transcriptomic, and proteomic approaches systematically investigate eight subtypes pituitary normal glands. By blocking IDH2, we IDH2...
Type-2 cannabinoid receptor (CB2R) is a member of the G protein-coupled superfamily with various biological activities in pain regulation, anti-inflammation, anti-fibrosis, and bone metabolism regulation. CB2R modulators have been demonstrated to significant regulatory effects on no psychoactive adverse effects. In this article, we present comprehensive review molecular mechanism regulating summarize virtual screening experimental methods for from natural synthetic products. Knowing that...
This investigation aims to elucidate the novel role of Stromal Interaction Molecule 1 (STIM1) in modulating store-operated calcium entry (SOCE) and its subsequent impact on inflammatory cytokine release T lymphocytes, thereby advancing our understanding trigeminal neuralgia (TN) pathogenesis. Employing Gene Expression Omnibus (GEO) database, we extracted microarray data pertinent TN identify differentially expressed genes (DEGs). A comparison with SOCE-related from Genecards database helped...
In somatic cells, homologous recombination (HR) is a rare event caused by eventual DNA double-strand breaks (DSBs). contrast, germ cells show high frequency of HR programmed DSBs. Microsatellites are prone to DSBs during genome replication and, thereby, capable promoting HR. It remains unclear whether occurs frequently at microsatellites both in normal and similar manner. By examining the linkage pattern multiple paternal maternal markers flanking innate GT microsatellites, we measured...