A5100371506- Protein Hydrolysis and Bioactive Peptides
- Luminescence Properties of Advanced Materials
- Insect Utilization and Effects
- Glass properties and applications
- Infant Nutrition and Health
- Plant Virus Research Studies
- Muscle metabolism and nutrition
- Aquaculture Nutrition and Growth
- Digestive system and related health
- Solid State Laser Technologies
- Biochemical effects in animals
- Meat and Animal Product Quality
- Olfactory and Sensory Function Studies
- Food Chemistry and Fat Analysis
- Metal Extraction and Bioleaching
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Extraction and Separation Processes
- Fatty Acid Research and Health
- Insect-Plant Interactions and Control
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- Phytochemical Studies and Bioactivities
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Synthesis of heterocyclic compounds
Hainan Medical University
2025
Inner Mongolia University of Technology
2024
Ningbo University
2014-2023
Zhejiang University
2014-2023
Nanjing Agricultural University
2022-2023
Children's Hospital of Zhejiang University
2022
Huazhong Agricultural University
2020
Beijing University of Chinese Medicine
2019
Sichuan University
2018
Hangzhou Academy of Agricultural Sciences
2017
Abstract PD-1 (CD279)–PD-L1 (CD274) inhibitory signaling is critical for cancer immune evasion, and thus has become one of the major targets in anticancer immunotherapy. There are several studies that demonstrate potent effects posttranslational modifications CD274 on inactivation suppression, such as ubiquitination, phosphorylation, glycosylation, palmitoylation. However, regulatory mechanisms deubiquitination still largely unclear. Here, we identified ubiquitin-specific protease 22 (USP22)...
Plant viruses adopt diverse virulence strategies to inhibit host antiviral defense. However, general defense directly targeted by different types of plant have rarely been studied. Here, we show that the single rice DELLA protein, SLENDER RICE 1 (SLR1), a master negative regulator in Gibberellin (GA) signaling pathway, is several viral effectors for facilitating infection. Viral proteins encoded all trigger rapid degradation SLR1 promoting association with GA receptor OsGID1. SLR1-mediated...
Olfactory dysfunction is an early event in Alzheimer's disease (AD). However, the mechanism underlying AD-related changes olfactory bulb (OB) remains unknown. Granule cells (GCs) OB regulate activity of mitral (MCs) through reciprocal dendrodendritic synapses, which crucial for signal processing and odor discrimination. Nevertheless, relationships between morphological functional particularly local field potentials (LFPs) as a consequence disorders patients with AD have not been...
Abstract Ile‐Pro‐Pro and Val‐Pro‐Pro are two most well‐known food‐derived bioactive peptides, initially identified as inhibitors of angiotensin I‐converting enzyme (ACE) from a sample sour milk. These peptides were in fermented enzymatic hydrolyzed cow non‐cow (that is, goat, sheep, buffalo, yak, camel, mare, donkey) milk, well sourdough prepared wheat, rye, malt. Similar to other bioavailability these is low (about 0.1%), reaching picomolar concentration human plasma; they showed blood...
Phosvitin (PV) from egg yolk is an excellent substrate for the production of phosphopeptides, which have a strong calcium chelating capacity and promoting absorption bone mineralization. This study investigated effect PV hydrolysates produced using effective preparation method (high temperature (121°C) mild pressure (0.1 MPa), HTMP) or HTMP pretreatment trypsin hydrolysis combination (HTMP-PV18) on physiology osteoblast MC3T3-E1 cells line. The proliferation, apoptosis, differentiation were...
Royal jelly, also called bee milk, is a source of high-quality proteins. jelly proteins serve as not only rich essential amino acids and functional donors but an excellent substrate for preparing bioactive peptides. Most naturally occurring peptides in royal are antibacterial, while derived from proteolytic reactions shown to exert antihypertensive, antioxidative, anti-aging activities. Further studies warranted characterize the properties major peptides, explore preparation potential novel...
Obesity-induced adipose chronic inflammation is closely related to the development of insulin resistance and T2DM. Tripeptides l-valyl-l-prolyl-l-proline (VPP) l-isoleucyl-l-prolyl-L-proline (IPP) derived from bovine casein have been reported prevent inflammatory changes mitigate in adipocytes. In this study, we aimed investigate influence hydrolysates (CH) containing VPP IPP on a high fat diet (HFD)-induced obese mice cytokine TNF-α-induced Our data showed that CH alleviated both vivo...
VPP (Val-Pro-Pro) and IPP (Ile-Pro-Pro) are two famous antihypertensive peptides with possible benefits for type 2 diabetes mellitus (T2DM). The study was aimed to investigate the effect of peptide analogues on glucose uptake activity in L6 myotubes. were designed by replacing N-terminal, middle, or C-terminal amino acid residues one at a time from five groups (polar, nonpolar, basic, acidic, aromatic acids). Among 26 tripeptides tested, IQP, IPQ, VPE, VEP showed significantly higher than...
Abstract Background The associations between body flexibility and sarcopenia were not well understood. This study aimed to explore the cross‐sectional longitudinal of with sarcopenia. Methods Our selected participants aged 50–80 from WELL‐China cohort Lanxi cohort. Participants urban area followed up 4 years later. Body was measured by sit‐and‐reach test. Muscle mass evaluated dual‐energy X‐ray absorptiometry. strength using handgrip strength. Sarcopenia defined as having both low muscle We...
LiYF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> single crystals codoped with Tb <sup xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> /Sm ions were synthesized by the vertical Bridgman method. When excited 374-nm ultraviolet light, emit violet-blue, blue, green, yellow, orange, and red light. The white light as a result of combination these emissions can be achieved from (1.25 mol%) Sm (2.22 crystal chromaticity coordinates x =...
Downconversion (DC) with emission of two near-infrared photons about 1000 nm for each blue photon absorbed was obtained in thulium (Tm3+) and ytterbium (Yb3+) codoped yttrium lithium fluoride (LiYF4) single crystals grown by an improved Bridgman method. The luminescent properties the were measured through photoluminescence excitation, spectra decay curves. Luminescence between 960 1050 from Yb3+: 2F5/2→2F7/2 transition, which originated DC Tm3+ ions to Yb3+ ions, observed under excitation at...
As an important integral part of traditional Chinese medicine chemical biology( TCMCB),it is great importance to rapid isolate,and reliably identify the components in herbal medicines. Phytochemical studies on anti-inflammatory active dragon's blood,the red resin Dracaena cochinchinensis,resulted isolation two compounds,nordracophane( 1) and dracophane( 2),using LC-MS chromatographic techniques( Silica gel,ODS preparative HPLC). The structures,cyclic dihydrochalcane trimers,were elucidated...