A5104652304- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Paleontology and Stratigraphy of Fossils
- Carcinogens and Genotoxicity Assessment
- Gut microbiota and health
- Geochemistry and Elemental Analysis
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Geological and Geochemical Analysis
- Advanced biosensing and bioanalysis techniques
- Neurotransmitter Receptor Influence on Behavior
- Medicinal Plant Pharmacodynamics Research
- Functional Brain Connectivity Studies
- Molecular Biology Techniques and Applications
- Paleontology and Evolutionary Biology
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Biological and pharmacological studies of plants
- Biosimilars and Bioanalytical Methods
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Bacillus and Francisella bacterial research
- IL-33, ST2, and ILC Pathways
- Fibroblast Growth Factor Research
- Heavy Metal Exposure and Toxicity
Northeast Agricultural University
2025
Inner Mongolia Medical University
2025
Osaka University
2024-2025
Northwest University
2024
Sichuan University
2022-2024
State Key Laboratory of Continental Dynamics
2024
Dalian Medical University
2023
First Affiliated Hospital of Dalian Medical University
2023
Yichang Central People's Hospital
2023
West China Hospital of Sichuan University
2023
Modulation of claudin-based bicellular tight junction (TJ) and angulin-based tricellular TJ seals has been shown to enhance mucosal permeation macromolecules, by using the receptor-binding fragments Clostridium perfringens enterotoxin (C-CPE194, C-CPEmt, C-CPEm19) iota-toxin (angubindin-1) as claudin modulators an angulin modulator, respectively. Here, we compared activity these on in human intestinal Caco-2 cells. All loosened integrity more potently angubindin-1 with order potency being...
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) (NAc-DBS) is an effective solution to refractory obsessive-compulsive disorder (OCD). However, evidence for neurobiological mechanisms OCD and effect NAc-DBS still lacking. One hypothesis that electrophysiological activities in NAc are modulated by DBS, another neurotransmitters influenced DBS. To investigate these potential alterations, rats with quinpirole (QNP)- induced were treated DBS core part NAc. Then, extracellular spikes...
Heat stress can cause testicular damage and affect male fertility. Tanshinone IIA (TSA) is a monomer substance derived from plants, with antioxidant anti-apoptotic effects. Whether it repair caused by heat unclear. This study aims to construct mouse injury model intervene TSA. Various methods such as histopathology, high-throughput sequencing, bioinformatics analysis, molecular biology were used investigate whether TSA alleviate stress-induced its mechanism. Results showed that significantly...
A major site for the absorption of orally administered drugs is intestinal tract, where mucosal epithelium functions as a barrier separating inside body from outer environment. The intercellular spaces between adjacent epithelial cells are sealed by bicellular and tricellular tight junctions (TJs). Although one strategy enhancing drug to modulate these TJs, comprehensive gene (mRNA) expression analysis TJs components has never been fully carried out in humans. In this study, we used human...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, leading to cartilage damage, bone erosion, even joint destruction and deformity. The conventional treatment modalities in RA are associated with side effects, emphasizing the need for alternative therapeutic remedies. Baicalin possesses multiple pharmacological effects advantage low toxicity. This study aimed reveal potential gene regulatory mechanisms underlying alleviating baicalin...
Abstract Background Parkinson's disease (PD) is a neurodegenerative disease, and its pathogenesis unclear. Previous studies mainly focus on the lesions of substantia nigra (SN) striatum (Str) in PD. However, are not limited. The olfactory bulb (OB), subventricular zone (SVZ), hippocampus (Hippo) also affected Aim To reveal gene expression changes five brain regions (OB, SVZ, Str, SN, Hippo), to look for potential candidate genes pathways that may be correlated with Materials methods We...
Contextual drug-associated memory precipitates craving and relapse in substance users, the risk of is a major challenge treatment use disorders. Thus, understanding neurobiological underpinnings how this association formed maintained will inform future advances drug addiction. Brain endocannabinoids (eCBs) signalling has been associated with drug-induced neuroadaptations, but role lipases that mediate small lipid ligand biosynthesis metabolism regulating not examined. Here, we explored...
Neuronal activation is required for the formation of drug-associated memory, which critical development, persistence, and relapse drug addiction. Nevertheless, metabolic mechanisms underlying energy production neuronal remain poorly understood. In study, a large-scale proteomics analysis lysine crotonylation (Kcr), type protein posttranslational modification (PTM), reveals that cocaine promoted Kcr in hippocampal dorsal dentate gyrus (dDG). We find predominantly discovered few enzymes...
Abstract Background Tanshinone IIA (TSA), a major lipophilic component extracted from the roots of Salvia miltiorrhiza Bunge , has been widely used in China for its various biological activities. However, effect on ovarian reserve aged mice was not studied elsewhere. Objectives This study aimed to explore TSA as well young mice. Forty weeks old (N = 40) were considered group compared 4 40), and these groups subdivided into four subgroups 10) receive different doses (0, 10, 20, 40 μg/g/day)....
Heart failure (HF) is one of the diseases that lead to high mortality patients. Finding natural compounds with cardioprotective properties and identifying their action mechanisms great importance. In this research, effect propolis triblock copolymer nano-vesicles loaded were studied in Wistar rats HF model. After preparing Polylactide-block-poly (ethylene glycol)-block-polylactide (PLA-PEG-PLA) using thin film hydration method, nanoparticles identified transmission electron microcopy (TEM)...
In eukaryotes, DNA replisome is a large protein complex that carries out replication, which contains several enzymatic subunits, such as helicase, RNA primase and polymerase. Replisome generates replication fork duplicates both the leading lagging strand of duplex DNA. Previous studies showed Ctf4 trimer proposed to be hub coordinate subunits in replisome, may link CMG Pol through binding CIP motif Sld5 a. By using single‐particle cryo‐EM an active on forked with dual biotin‐streptavidin...
According to the research results of 2022, blue book depression in China, there exists about 95,00,000 patients China and number is still growing. Depression becoming an increasingly severe disease. As it generally believed that etiology multifaceted, related gender differences, chronic stress, dietary behavior, abuse drugs alcohol. Clinical treatment mainly on drugs, but BCI methods cannot be ignored. Compared traditional methods, like Electroconvulsive therapy (ECT), repetitive...
Abstract During the Precambrian–Cambrian transition, tubicolous animals were prevalent among small shelly fossils. These include oldest‐known skeletal fossil Cloudina from terminal Ediacaran, and anabarites hyoliths early Cambrian; considered to be possible annelids, cnidarians, molluscs, respectively. Tubular fossils have important bio‐stratigraphic significance during this period, their diversity evolutionary radiation trend herald Cambrian explosion. However, relative morphological...
The fluorescence intensity of double-stranded DNA (ds-DNA) hybridized by fluorescent 2-aminopurine (2-AP) oligonucleotide probe and different mismatched bases was studied spectra in this paper. experiment designed synthesised four sequences with the adenine (A), cytosine (C), guanine (G), thymine (T), determined DNA. results implied that varied due to bases. And 546.9 ratio 3.13, which showed a significantly increase as base A. While T, quenched 43.26, 0.25. For C G, 2-AP 99.14 89.03,...
To perform a bibliometrics analysis on patent literature regarding diagnosis and treatment devices of acupuncture in China, aiming to provide references for the development acupuncture.Based SooPAT, database, China was collected. With methods, annual distribution type, quantity, classification content were analyzed.The number reached its peak 2012 2013 China. The A61N utility model most, which mainly related electrotherapy, magnetic therapy, radioactive therapy ultrasound etc. main meridian...