A5102013495- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Pharmacological Effects of Natural Compounds
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Hepatitis C virus research
- Epilepsy research and treatment
- Metabolism, Diabetes, and Cancer
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Atmospheric and Environmental Gas Dynamics
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Atmospheric Ozone and Climate
- Receptor Mechanisms and Signaling
- Neonatal and fetal brain pathology
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
Ningxia Medical University
2015-2025
Anhui Medical University
2024
Ningxia Medical University General Hospital
2015-2023
North Carolina Central University
2023
Hadassah Medical Center
2022
First Hospital of Jilin University
2021
Jilin University
2021
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2021
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2019-2020
Yinchuan First People's Hospital
2020
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an event. However, in-depth mechanistic understanding of their connection remains limited. This study aims to comprehensively analyze gene expression patterns pyroptosis-related differentially expressed genes (PRDEGs) employing integrated IS datasets machine learning techniques. primary objective was develop classification models identify crucial PRDEGs...
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg for 3 consecutive days. effectively prevented pilocarpine-induced mouse kindling model, suppressed nuclear factor-κB activation expression, inhibited excessive discharge of hippocampal neurons...
Summary Hepatic allograft rejection remains a challenging problem, with acute episode as the major barrier for long-term survival in liver transplant recipients. To explore strategy to prevent rejection, we hypothesized that mesenchymal stem cells (MSCs) genetically engineered interleukin-10 (IL-10) could produce beneficial effects on orthotopic transplantation (OLT) experimental rat model. Syngeneic MSCs transduced IL-10 were delivered via right jugular vein 30 min post-orthotopic evaluate...
The aims of this study are to clarify the role mTOR in mediating cerebral ischemic brain damage and effects rapamycin on outcomes.Ten minutes forebrain ischemia was induced rats, their brains were sampled after 3 h, 16 7 days reperfusion for histology, immunohistochemistry biochemical analysis.Our data demonstrated that resulted both apoptotic necrotic neuronal death; led significant increases mRNA protein levels p-mTOR its downstream p-P70S6K p-S6; elevation LC3-II, release cytochrome c...
Blood-testis barrier (BTB) impairments is one of the major secondary complications diabetes. Betaine (BET) important active ingredients isolated from Lycium barbarum, which exhibits numerous pharmacological activities such as antioxidant, anti-diabetic, and anti-inflammatory effects. This study aimed to establish whether BET contributes recovery BTB dysfunction in streptozotocin (STZ) induced diabetic mice.BET (200, 400, 800 mg/kg) was orally administered mice for 8 weeks. Testis tissues...
Neonatal hypoxic-ischemic brain damage (HIBD) is a leading cause of death and perpetual neurological dysfunction in neonates. Vanillin (Van), natural phenolic compound with neuroprotective properties, exerts neuroprotection on gerbil model global ischemia by inhibiting oxidative damage. This study aimed to explore the potential roles Van neonatal rats suffering from (HI). An HI 7-day-old SD was induced left carotid artery ligation followed exposure 8% oxygen (balanced nitrogen) for 2.5 h at...
The objectives of the present study are to investigate activation mTOR and ERK1/2 signaling after cerebral ischemia in diabetic rats examine neuroprotective effects rapamycin. Ten minutes transient global was induced straptozotocin-induced hyperglycemic non-diabetic, euglycemic rats. Brain samples were harvested 16 h reperfusion. Rapamycin or vehicle injected 1 month prior induction ischemia. results showed that diabetes increased ischemic neuronal cell death associated with elevations...
This study investigated the anti-inflammatory and analgesic activities of indigo in mice explored possible related mechanisms.
Actin remodeling plays important roles in pathophysiological processes such as cancer metastasis and angiogenesis. Reactive oxygen species (ROS) are signaling molecules thought to regulate cell migration by actin cytoskeleton. Earlier, we demonstrated that Transient receptor potential melastatin 2 (TRPM2) channels mediates H2O2-induced HeLa cells manipulating Ca2+ Zn2+. However, the mechanism which ROS produced models more relevant circumstances affect cytoskeleton, remains poorly unknown....
Cerebral ischemia-reperfusion (I-R) transiently increased autophagy by producing excessively reactive oxygen species (ROS); on the other hand, activated would remove ROS-damaged mitochondria and proteins, which led to cell survival. However, regulation mechanism of activity during cerebral I-R is still unclear. In this study, we found that deficiency TRPM2 channel a ROS sensor significantly decreased I-R-induced neuronal damage. both in vitro vivo. More importantly, neurological deficit...
Hyperglycemia is known to exacerbate neuronal death resulted from cerebral ischemia. The mechanisms are not fully understood. mammalian target of rapamycin (mTOR) pathway regulates cell growth, division and apoptosis. Recent studies suggest that activation mTOR may mediate ischemic brain damage. objective the present experiment explore whether mediates damage in acute hyperglycemic animals. Rats were subjected 10 min forebrain ischemia under euglycemic, rapamycin-treated conditions. rat...
Hyperglycemia is one of the major risk factors for stroke and recurrence, leading to aggravated neuronal damage after cerebral ischemia/reperfusion (I/R). ERK1/2 signaling pathway plays a vital role in ischemic injury. However, hyperglycemia-aggravated brain not clear. Streptozotocin (STZ; 50 mg/kg)-induced diabetes (blood glucose ≥12 mmol/L) or control groups adult Sprague-Dawley rats were further subdivided into I/R (carotid artery/vein clamping), + PD98059 (I/R plus inhibitor),...
Intracerebral hemorrhage usually manifests as strong neuroinflammation and neurological deficits. There is an urgent need to explore effective methods for the treatment of intracerebral hemorrhage. The therapeutic effect possible mechanism induced neural stem cell transplantation in rat model are still unclear. Our results showed that cells could improve deficits by inhibiting inflammation model. Additionally, effectively suppress microglial pyroptosis, which might occur through NF-κB...