A5080910430- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Neuroprotection
- Nanoparticle-Based Drug Delivery
- Vanadium and Halogenation Chemistry
- Pharmacogenetics and Drug Metabolism
- Advanced Nanomaterials in Catalysis
- Peroxisome Proliferator-Activated Receptors
- Sulfur Compounds in Biology
- Vitamin D Research Studies
- Nanoparticles: synthesis and applications
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Vitamin C and Antioxidants Research
- Saffron Plant Research Studies
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Curcumin's Biomedical Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Medical and Biological Ozone Research
- Mass Spectrometry Techniques and Applications
- Piperaceae Chemical and Biological Studies
- Pharmacological Effects of Natural Compounds
China Pharmaceutical University
2016-2024
University of Copenhagen
2018-2021
Oxidative stress plays an important role in the pathogenesis of acute lung injury (ALI). As a typical post-translational modification triggered by oxidative stress, protein S-glutathionylation (PSSG) is regulated redox signaling pathways and diverse roles conditions. In this study, we found that GSTP downregulation exacerbated LPS-induced human epithelial cells mice ALI models, confirming protective effect against both vitro vivo. Additionally, positive correlation was observed between total...
Abstract Palmitoyl ascorbate (PA) as an antioxidant has the potential for treatment of cancer. In present study, a nanocarrier system was developed co-delivery docetaxel (DOC) with palmitoyl and therapeutic efficacy combination drug regimen investigated. For this purpose, different ratios were co-encapsulated in liposome they all showed high encapsulation efficiency. The average diameters liposomes ranged from 140 to 170 nm. Negative zeta values observed systems, −40 mV −56 mV. Studies on...
The precise characterization and quantification of oxidative protein damage is a significant challenge due to the low abundance, large variety, heterogeneity modifications. Mass spectrometry (MS)-based techniques at peptide level (proteomics) provide detailed but limited picture incomplete sequence coverage imperfect enzymatic digestion. This particularly problematic with oxidatively modified cross-linked/aggregated proteins. There pressing need for methods that can quantify numbers amino...
A host of chronic inflammatory diseases are accelerated by the formation powerful oxidant hypochlorous acid (HOCl) myeloperoxidase (MPO). In presence thiocyanate (SCN-), production HOCl MPO is decreased in favour a milder oxidant, hypothiocyanous (HOSCN). The role HOSCN disease has not been fully elucidated, though there increasing interest using SCN- therapeutically different settings. Unlike HOCl, can be detoxified thioredoxin reductase, and reacts selectively with thiols to result...
Myeloperoxidase (MPO) is a vital component of the innate immune system, which produces potent oxidant hypochlorous acid (HOCl) to kill invading pathogens. However, an overproduction HOCl during chronic inflammatory conditions causes damage host cells, promotes disease, including atherosclerosis. As such, there increasing interest in use thiocyanate (SCN−) therapeutically decrease as SCN− favoured substrate for MPO, and competitive inhibitor formation. Use by MPO forms hypothiocyanous...
Genipin (GP), the reactive metabolite of geniposide (GE), is responsible for GE-induced hepatotoxicity. As a potential detoxification pathway, inactivation GP by glutathione S-transferases (GSTs) has not yet been characterized. In this study, thiol-GSH conjugates GP, M532-1 and M532-2 were first identified catalytic activities GSTs investigated both in vitro vivo. GSTA1-1 GSTA4-4 showed high activity formation conjugates, whereas specifically catalyzed vitro. The active GST isoforms protect...
1. Case reports have shown that coadministration of fenofibric acid (FA) could increase bleeding risks warfarin, but the mechanisms remained unknown. We therefore investigated pharmacokinetic and pharmacodynamic interaction between warfarin FA in rats. 2. Rats received alone (2 mg/kg) or coadministered with (100 mg/kg). significantly increased exposure to decreased 7-hydroxywarfarin rats nearly by two-fold, meanwhile Cmax prolonged t1/2 warfarin. Anticoagulant activity increased, prothrombin...
Genipin (GP) is the reactive aglycone of geniposide, main component traditional Chinese medicine Gardeniae Fructus (GF). The covalent binding GP to cellular proteins suspected be responsible for GF-induced hepatotoxicity and inhibits drug-metabolizing enzyme activity, although mechanisms remain clarified. In this study, GP-induced human hepatic P450 inactivation were systemically investigated. Results showed that inhibited all tested isoforms via distinct mechanisms. CYP2C19 was directly...
Myeloperoxidase (MPO) is involved in the development of many chronic inflammatory diseases, addition to its key role innate immune defenses. This attributed excessive production hypochlorous acid (HOCl) by MPO at sites, which causes tissue damage. has sparked wide interest therapeutic approaches prevent HOCl-induced cellular damage including supplementation with thiocyanate (SCN−) as an alternative substrate for MPO. In this study, we used enzymatic system composed glucose oxidase (GO),...