A5101942692- Sirtuins and Resveratrol in Medicine
- Nanoparticle-Based Drug Delivery
- Family Support in Illness
- Adipose Tissue and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Nanoplatforms for cancer theranostics
- Diet and metabolism studies
- Advanced Causal Inference Techniques
- PARP inhibition in cancer therapy
- Pancreatic function and diabetes
- Analytical chemistry methods development
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Nanoparticles: synthesis and applications
- Bioactive natural compounds
- Metabolomics and Mass Spectrometry Studies
- Urinary Bladder and Prostate Research
- Vitamin D Research Studies
- Urologic and reproductive health conditions
- Graphene and Nanomaterials Applications
- Spine and Intervertebral Disc Pathology
- Regulation of Appetite and Obesity
Central South University
2020-2025
Xiangya Hospital Central South University
2025
Chengdu Medical College
2021-2025
National University of Singapore
2018-2024
Guiyang Medical University
2024
Chinese Academy of Sciences
2024
Shenzhen Technology University
2024
Institute of Geochemistry
2024
Anhui Medical University
2020-2023
Third Xiangya Hospital
2023
Abstract Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This cleaved from reticulocalbin-2 (RCN2), name it Raptin. Raptin release timed by circuit vasopressin-expressing neurons suprachiasmatic nucleus to RCN2-positive paraventricular nucleus. levels peak during sleep, which blunted sleep deficiency. binds glutamate...
Abstract Nonalcoholic steatohepatitis (NASH) has rapidly become the most common cause of chronic liver diseases. We aimed to explore incidence and distribution characteristics NASH by sex, region sociodemographic index (SDI). collected data, including sex region, on NASH-related cirrhosis from 2017 GBD study. The age-standardized rates (ASRs) estimated annual percentage changes (EAPCs) were used estimate trend characteristics. Globally, caused increased 178,430 cases in 1990 367,780 2017, an...
Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-Dawley rats. Methods: The plasma pharmacokinetics metabolomics monitored by liquid chromatography-tandem mass spectrometry (LC-MS/MS) gas (GC-MS/MS), respectively. Results: Upon...
Abstract Palmitoyl ascorbate (PA) as an antioxidant has the potential for treatment of cancer. In present study, a nanocarrier system was developed co-delivery docetaxel (DOC) with palmitoyl and therapeutic efficacy combination drug regimen investigated. For this purpose, different ratios were co-encapsulated in liposome they all showed high encapsulation efficiency. The average diameters liposomes ranged from 140 to 170 nm. Negative zeta values observed systems, −40 mV −56 mV. Studies on...
Atorvastatin and its lactone form metabolite are reported to be associated with statin-induced myopathy (SIM) such as myalgia life-threatening rhabdomyolysis. Though the rhabdomyolysis is not common during statin therapy, incidence will significantly increase due pharmacokinetic drug-drug interactions (DDIs) inhibitor drugs which inhibit atorvastatin's lactone's metabolism hepatic uptake. Thus, quantitative analysis of DDIs atorvastatin cytochrome P450 3A4 (CYP3A4) organic anion-transporting...
Resveratrol (trans-3,5,4′-trihydroxystilbene, RES) is one of the most well-known natural products with numerous health benefits. To explore nutraceutical potentials some dietary RES derivatives including isorhapontigenin (trans-3,5,4′-trihydroxy-3′-methoxystilbene, ISO), oxyresveratrol (trans-3,5,2′,4′-tetrahydroxystilbene, OXY) and pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene, PTS), their impacts on metabolism were assessed in Sprague Dawley rats after a two-week daily oral...
Introduction Studies have revealed that Tai Chi can enhance cognitive functions among patients with mild impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive. Methods Consequently, we conducted a study involving 54 elderly inpatients MCI residing in combined medical and care facility Chengdu, who were randomly divided into three groups: control group engaging daily living activities, performed exercises addition to walking undertook activities as...
To evaluate the health-promoting potentials of piceatannol (PIC), a dietary resveratrol derivative, its biotransformation is examined.The tested in human/rat hepatic microsomes and cytosols; pharmacokinetic profiles are assessed rats. Although limited phase I metabolism exists microsomes, PIC rapidly converted to two pharmacologically active metabolites, namely rhapontigenin (RHA) isorhapontigenin (ISO) cytosols. Such completely blocked by entacapone, well-known catechol-O-methyltransferase...
Abstract Objectives The clinical application of doxorubicin (DOX) is limited by severe systemic side effects. aim this study was to develop a strategy that combined the liposomal DOX (LipDOX) and intratumoral injection reduce toxicity enhance antitumor efficiency. Methods pharmacokinetics, tissue distribution pharmacodynamics LipDOX compared with free were investigated in murine H22 hepatoma-bearing mice at dose 20 mg/kg body weight. A sensitive HPLC-tandem mass spectrometry method used...
Background During the design phase of a clinical trial, sample size estimates should take into account medical screening criteria, ‘healthy volunteer’ effect, consequences run-in phases, and secular trends in event rate interest. All these have been shown to relate subsequent rates, hence trial power detect intervention effects. The Multiple Risk Factor Intervention Trial (MRFIT) used three successive screenings 361 662 men enroll 12 866; observed coronary heart disease (CHD) mortality after...
Methimazole (MMI) has been used in the therapy of Grave's disease (GD) since 1954, and drug-induced liver injury (DILI) is one most deleterious side effects. Genetic polymorphisms drug-metabolizing enzymes drug transporters have associated with hepatotoxicity many cases. The aim this study was to investigate genetic susceptibility MMI-DILI. A total 44 GD patients MMI-DILI 118 without development were included study. Thirty-three single nucleotide (SNPs) twenty candidate genes genotyped. We...
Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions its pharmacological active metabolite (AM) inactive carboxylic acid (CAM). This study demonstrated the interspecies differences vicagrel bioactivation by comparing critical metabolites formation in rats, dogs human. The pharmacokinetic studies with rats were conducted after intragastric administration followed vitro metabolism investigation venous...