A5102185147- COVID-19 Clinical Research Studies
- Autonomous Vehicle Technology and Safety
- Traffic and Road Safety
- Infectious Encephalopathies and Encephalitis
- Hepatitis B Virus Studies
- Advanced Image Fusion Techniques
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Video Surveillance and Tracking Methods
- Traditional Chinese Medicine Studies
- Herpesvirus Infections and Treatments
- Glycosylation and Glycoproteins Research
- Liver Disease and Transplantation
- Influenza Virus Research Studies
- NF-κB Signaling Pathways
- Cutaneous lymphoproliferative disorders research
- Natural Language Processing Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Fuzzy Logic and Control Systems
- Image Retrieval and Classification Techniques
- Remote-Sensing Image Classification
- Liver Disease Diagnosis and Treatment
- Bartonella species infections research
- Respiratory viral infections research
- Chemical Synthesis and Analysis
Xinjiang University
2023-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2011-2020
Sun Yat-sen University
2011-2020
Huazhong University of Science and Technology
2008-2018
Tongji Hospital
2008-2018
Abstract Background The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. adage “old drug, new trick” in this context may suggest the important therapeutic potential existing drugs. We found that lopinavir/ritonavir recommended fifth edition Treatment Plan China can only help to improve a minority throat-swab nucleic-acid results (3/15) hospitals. Our previous use chloroquine treat patients with infection showed an...
Fibrinogen-like protein 2 (FGL2)/fibroleukin plays a pivotal role in the pathogenesis of experimental and human fulminant chronic viral hepatitis. To define transcription factor(s) upstream signal transduction pathways involved FGL2 (hFGL2) response to hepatitis B (HB) virus, core (HBc), virus S (HBs), or X (HBx) protein, expression plasmids were cotransfected with an hFGL2 promoter luciferase reporter construct into Chinese hamster ovary HepG2 cells, respectively. HBc HBx proteins, but not...
Potassium channel tetramerisation domain containing 9 (KCTD9), a member of KCTD family with DNA-like pentapeptide repeat domain, was found to be increased particularly in NK cells patients HBV-induced acute-on-chronic liver failure (HBV-ACLF) and experimental viral fulminant hepatitis. Knockdown KCTD9 immortalized inhibits cytokines production cytotoxicity. As cell activation shown exacerbate damage hepatitis, we propose that target inhibition may prohibit activity thus ameliorate...
Abstract Background The outbreak of novel coronavirus pneumonia is very serious, and no effective antiviral treatment has been confirmed. fresh drug research development cycle too long to meet clinical emergency needs, "old drugs brand new applications" have a huge therapeutic potential. During our previous treatment, we found that the lopinavir/ritonavir recommended in Fifth edition plan had little effect. Earlier studies shown chloroquine can inhibit replication through multiple...
Background: At present, there are some problems in multimodal medical image fusion, such as texture detail loss, leading to edge contour blurring and energy contrast reduction. Objective: To solve these obtain higher-quality fusion images, this study proposes an method based on local saliency multi-scale fractal dimension. Methods: First, by using a non-subsampled contourlet transform, the was divided into 4 layers of high-pass subbands 1 layer low-pass subband. Second, order fuse 2 4, rules...
<title>Abstract</title> This paper proposes an innovative Spatiotemporal Variational Autoencoder (ST-VAE) model, aimed at effectively capturing the spatiotemporal features of pedestrian behavior to enhance accuracy trajectory prediction intersections. To address complex relationships in social interactions, designs a Social Graph Attention Network (SGAT) that dynamically identifies relative importance traffic participants, optimizing interaction analysis. Additionally, introduces Complex...
<title>Abstract</title> Machine translation is a critical area in natural language processing, aiming to achieve automatic between different languages. Despite significant progress multilingual tasks with neural machine models, many challenges remain handling low-resource These mainly arise from the limited availability of parallel corpora for training and differences grammatical structures expressions among Based on this, this study proposes an iterative ensemble pruning data augmentation...
Objective To investigate the clinical characteristics of skin lesions tsutsugamushi disease.Methods The and 17 hospitalized patients with disease were analyzed. Results Of patients, 88.2% (15/17) developed eschar ulcer, 64.7% (11/17) had rashes. often solitary, painless nonpruritic 4 to 10 days after occurrence fever, indefinite locations average diameter 1.2 cm (range: 0.5 - 3.0 cm). was covered a black dry surface surrounded by ring-shaped erythematous halo, usually shedded 5 9 appearance...
Abstract Background The outbreak of novel coronavirus pneumonia is very serious, and no effective antiviral treatment has been confirmed. fresh drug research development cycle too long to meet clinical emergency needs, "old drugs brand new applications" have a huge therapeutic potential. During our previous treatment, we found that the lopinavir/ritonavir recommended in Fifth edition plan had little effect. Earlier studies shown chloroquine can inhibit replication through multiple...