A5101597035- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Syphilis Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Reproductive tract infections research
- Infectious Diseases and Tuberculosis
- Antibiotics Pharmacokinetics and Efficacy
- MicroRNA in disease regulation
- HIV, Drug Use, Sexual Risk
- Streptococcal Infections and Treatments
- Circular RNAs in diseases
- HIV Research and Treatment
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Nanoplatforms for cancer theranostics
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Blood groups and transfusion
Sichuan University
2016-2025
Oil Crops Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Hubei University of Technology
2025
West China Hospital of Sichuan University
2015-2024
Guangxi Center for Disease Prevention and Control
2022
Recently, hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of virus (HBV) infection. This study aimed to investigate whether serum quantitative HBcrAg (qHBcrAg) was a satisfactory surrogate intrahepatic covalently closed circular DNA (cccDNA). A total 139 patients with liver biopsy were enrolled, consisting 59 in immune tolerance (IT) phase, 52 clearance (IC) 18 low-replication (LR) and 10 reactivation phase. All IC phase have received entecavir (ETV)...
In China, the spread and outbreak of OXA-48-producing Enterobacteriaceae remains largely unknown.OXA-48-producing isolates were analyzed for genetic relatedness by pulsed-field gel electrophoresis (PFGE), antimicrobial susceptibility E-test, sequence type (ST) multilocus typing. S1-PFGE southern blotting used plasmid profiling, PCR subsequent sequencing performed to determine environment blaOXA-48 gene.In total, 37 non-duplicated K. pneumoniae (OXAKp) recovered. From December 2013 August...
The increasing prevalence and mortality of multidrug-resistant (MDR) Acinetobacter baumannii complex-associated infections, especially bacteremia, in health care settings poses a great threat to public health. We proceeded investigate the risk prognostic factors for MDR A. complex bacteremia mainland China.This retrospective study was conducted at West China Hospital from January 2009 December 2013. Using computer-assisted microbiology laboratory database, patients with were included as case...
Background As the fifth most common cancer worldwide, Hepatocellular carcinoma (HCC) is also third cause of cancer-related death in China. Several lncRNAs have been demonstrated to be associated with occurrence and prognosis HCC. However, identification prognostic lncRNA signature for HCC expression profiling data has not conducted yet. Methods With reuse public available TCGA data, profiles 371 patients were obtained analyzed find independent lncRNA. Based on lncRNA, we developed a risk...
Abstract Background & Aims Dysregulated iron homeostasis plays an important role in the hepatic manifestation of metabolic‐associated fatty liver disease (MAFLD). We investigated causal effects five metabolism markers, regular supplementation and MAFLD risk. Methods Genetic summary statistics were obtained from open genome‐wide association study databases. Two‐sample bidirectional Mendelian randomization analysis was performed to estimate effect between status MAFLD, including...
Abstract Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to investigate genotypes antiviral resistant mutations multi-ethnic area. A total of 1316 patients were recruited from four ethnic groups 2011 2013. Genotypes determined by Sanger sequencing. Four (B, C, D C/D) identified. Genotype C common Han population, while genotype was predominant...
To investigate the epidemiological features and risk factors of HBV, HCV, syphilis infection among HIV‐infected patients in West China Hospital. A retrospective study was conducted with from 2014 to 2016 hospital, SCU. Serum makers for were detected. Among 894 patients, prevalence HIV/HBV, HIV/HCV, HIV/syphilis co‐infections 14.4%, 5.7%, 18.9% respectively. HIV/HBV/HCV, HIV/HCV/syphilis, HIV/HBV/syphilis triple co‐infection 7 (0.7%), 12(1.3%), 29(3.2%) The rate effective vaccination against...
Thrombocytopenia frequently occurs with HIV-1 infection and plays a vital role in the deterioration of Blood-Brain Barrier (BBB) development neuroinflammation. This study aims to assess prevalence risk factors for associated thrombocytopenia (HAT) summarize characteristics HAT-related A retrospective HAT patients was conducted general teaching hospital from January 2017 December 2021. Clinical laboratory data HIS LIS were analyzed determine manifestations The 11.06%, majority male (76.92%),...
Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated with liver diseases. But because of population heterogeneity, different races would causative polymorphisms. Therefore, in this study, we included Chinese Tibetans Uygurs to examine the roles these genes on HBV natural clearance. A total 1341 subjects including 908 433 were recruited. Seven single nucleotide polymorphisms (SNP) genotyped. HLA-DP/DQ clearance both ethnicities (Tibetans, rs3077,...
Syphilis is a health problem of increasing incidence in recent years that may have severe complications if not diagnosed and treated at an early stage. There are many diagnostic tests available for syphilis, but there no gold standard, diagnosis therefore usually relies upon combination tests. In this multicenter study, we evaluated the treponemal Elecsys syphilis assay use routine samples, i.e., when suspected or during antenatal blood donation screening. The sensitivity specificity were...