A5101836992- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- Vitamin D Research Studies
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Health and Medical Studies
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Bariatric Surgery and Outcomes
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- HIV/AIDS Impact and Responses
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
MUC Research (Germany)
2015-2024
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2014-2020
Bayer (Germany)
2019
Universitätsklinikum Erlangen
2018
Hospital of the Brothers of St. John of God
2016
Klinikum Vest
2015
University Hospital Cologne
2015
Goethe University Frankfurt
2015
University Medical Center Hamburg-Eppendorf
2015
Universität Hamburg
2015
Abstract We investigated the relationship between hepatitis B virus surface antigen (HBsAg) serum level decline and posttreatment response in patients with e (HBeAg)-negative chronic from a large multinational study of pegylated interferon alfa-2a (peginterferon alfa-2a), or without lamivudine, versus lamivudine alone. Serum HBsAg was quantified using Architect assay (Abbott Diagnostics) at pretreatment, end treatment (week 48), 6 months after 72) sera 386 537 who participated alfa-2a, 127;...
Dolutegravir (DTG), a second-generation integrase strand transfer inhibitor (INSTI), is now among the most frequently used antiretroviral agents. However, recent reports have raised concerns about potential neurotoxicity.We performed retrospective analysis of cohort HIV-infected patients who had initiated an INSTI in two large German out-patient clinics between 2007 and 2016. We compared discontinuation rates because adverse events (AEs) within 2 years starting treatment with dolutegravir,...
Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly Africa, suggested a higher risk for severe MPXV cases in people living with HIV.This was retrospective study all confirmed observed the participating centres since 19 2022. We conducted chart review to evaluate clinical characteristics, comorbidities, coinfections, including HIV, viral hepatitis, sexually transmitted (STIs).By 30 June total 546 were...
Plasma uric acid was investigated in a population survey on diabetes and cardiovascular risk factors among Melanesians Asian Indians Fiji 1980. levels were elevated men women with impaired glucose tolerance both ethnic groups. The lowest plasma found diabetic patients, especially men. Even though obesity positively associated acid, it did not explain the high level persons tolerance. Body mass index had significant independent impact nondiabetic women. strongest predictor of multiple...
Abstract Purpose To evaluate the association between percentages of older age groups among confirmed SARS-CoV-2 infections and country-specific case fatality rate (CFR). Methods This ecological study analyzed data from 20 most severely affected European countries, USA Canada, in which national health authorities provided on distribution gender cases deaths. Results The proportion individuals than 70 years differed markedly ranging 4.9 to 40.4%. There was a strong linear 75 CFRs ( R 2 = 0.803...
To evaluate the impact of immune recovery induced by highly active antiretroviral therapy (HAART) on survival AIDS patients with primary central nervous system lymphoma (PCNSL).In a multicentric retrospective analysis, 29 HIV-infected histologically confirmed PCNSL were identified. median survival, Kaplan-Meier statistics used. explore effects different variables Weibull accelerated failure time regression analysis was performed.Median age at manifestation 39.1 years and CD4 cell count 11 x...
To describe the humoral immune response to COVID-19 vaccines in people living with HIV and identify factors associated magnitude of anti-SARS-CoV-2 antibody concentrations.Retrospective analysis electronic patient files a big single center Munich, Germany. Non-parametric methods were used for descriptive comparative statistics. Generalized linear models analyze associations general HIV-specific variables concentrations after standard vaccination.Overall, 665 included into (median age: 53...
Background: AIDS-related lymphoma (ARL) remains a frequent complication of HIV infection. We analyzed the outcome patients with ARL respect to use and efficacy highly active antiretroviral therapy (HAART) potential prognostic factors. Methods: This multicenter cohort study included systemic diagnosed between 1990–2001. evaluated overall survival effects several variables on using Kaplan–Meier method extended Cox proportional hazards model. Response HAART was used as time-dependent variable...
Hodgkin's disease (HD) is the most common non-acquired immunodeficiency syndrome (AIDS)-defining malignancy in human virus (HIV)-infected patients. We analysed outcome of patients with HIV-associated HD (HIV-HD) respect to use and efficacy highly active antiretroviral therapy (HAART) other prognostic factors. To evaluate effects several variables on overall survival (OS), Kaplan-Meier statistics extended Cox regression analysis were performed. Response HAART was used as a time-dependent...
At present sequential monotherapy for chronic hepatitis B with virus (HBV)-polymerase inhibitors is clinical practice. It unknown to date whether combination therapy lamivudine plus tenofovir could be superior after the occurrence of resistance.We conducted a multicenter, 1: 2 matched pair analysis comparing patients HBV/HIV-coinfection starting an antiretroviral regimen including who had highly replicative, resistant HBe-antigen positive and started as only active HBV polymerase inhibitor...
The evidence for a genetic determination of susceptibility to leprosy is reviewed. To test the hypothesis that an HLA (histocompatibility leukocyte antigen)-linked gene associated with such susceptibility, association between distribution within family and segregation haplotypes was investigated among 72 families who lived in Karigiri, Tamil Nadu State, South India. A statistically significant found which siblings had tuberculoid neither parent leprosy. findings from data this study agree...
<i>Background:</i> Genotypic drug resistance testing provides essential information for guiding treatment in HIV-infected patients. It may either be used identifying patients with transmitted or to clarify reasons failure and check remaining options. While different approaches the interpretation of HIV sequence are already available, no other available rules-based systems specifically have looked into effects combinations drugs. HIV-GRADE (Genotypischer Resistenz Algorithmus...
The potential toxicity of long-term antiretroviral therapy (ART) requires ongoing investigation novel strategies for treatment HIV-infected patients. Monotherapy with the integrase inhibitor (INSTI) dolutegravir (DTG) may offer a favourable safety profile. Additionally, DTG has high barrier resistance, crucial successful maintenance virological control. However, published data is sparse.Retrospective, single-centre cohort study. We enrolled patients on suppressive ART who were switched to...
Background Broad use of tenofovir and an ageing HIV-infected population have created interest in renal function HIV patients. Serum cystatin C is a newer marker might be more sensitive than creatinine. Methods Patients were enrolled consecutively observational study. HIV-seropositive patients naive to antiretroviral therapy ( n=261) compared with healthy volunteers undergoing check-up procedures n=193). Estimated glomerular filtration rate (eGFR) was derived using creatinine-based...
Objective To identify prevalence and risk factors associated with the HIV‐associated lipodystrophy syndrome (HIVLD) after 3 years of antiretroviral therapy, to investigate diagnostic value anthropometric measures assess impact HIVLD on quality life. Design methods A prospective, cross‐sectional, multicentre, observational, cohort study was performed in 27 German teaching hospitals, nonacademic hospitals private practices. total 221 HIV‐positive patients commencing therapy between July...
To test the hypothesis of an association between periodontosis and HLA-complex, 30 unrelated patients 8 families were tissue typed for HLA-A -B antigens. The divided in two groups on ethnic basis. Control consisted individuals same origin. In Negroid group I a statistically significant increase frequency HLA-BW35 was found. However, this significance not apparent when compared to control matched geographical location as well No differences observed Caucasoid II. segregation patterns HLA...
Highly specific reasons for nonadherence to antiretroviral therapy: results from the German adherence study Johanna Boretzki,1,2 Eva Wolf,3 Carmen Wiese,4 Sebastian Noe,4 Annamaria Balogh,3 Anja Meurer,5 Ivanka Krznaric,6 Alexander Zink,7 Christian Lersch,1 Christoph D Spinner1,2 1Department of Medicine II, University Hospital Klinikum rechts der Isar, Munich, 2German Center Infection Research, Partner Site 3MUC 4MVZ Karlsplatz, HIV Clinical Care Center, 5Center Infectiology and Internal...
Dolutegravir (DTG) and boosted darunavir (bDRV) are potent antiretrovirals with a high resistance barrier might be valuable switch options for people HIV (PWH).DUALIS, randomized, open-label, phase 3b, noninferiority clinical trial, compared the to DTG + bDRV (2DR) continuation of 2 nucleoside reverse transcriptase inhibitors (2NRTI) (3DR). PWH RNA <50 copies/mL taking 2NRTI (3DR) ≥24 weeks (1 accepted blip <200 copies/mL) were randomized either 50 mg DRV 800 (boosted 100 ritonavir) or...