A5101653604- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Inflammation biomarkers and pathways
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- HIV, Drug Use, Sexual Risk
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Impact on Reproduction
- Pediatric Hepatobiliary Diseases and Treatments
- Enhanced Recovery After Surgery
- Macrophage Migration Inhibitory Factor
- Gallbladder and Bile Duct Disorders
- Protein purification and stability
- Maternal and Neonatal Healthcare
- Nutrition and Health in Aging
- Thyroid Cancer Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Trypanosoma species research and implications
- Ginseng Biological Effects and Applications
- Thyroid Disorders and Treatments
- Animal Virus Infections Studies
- Hernia repair and management
- Sex and Gender in Healthcare
- Gastroesophageal reflux and treatments
Sichuan University
2013-2024
West China Hospital of Sichuan University
2016-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2019
Stanford University
2018
Stanford Medicine
2018
Shanghai University of Traditional Chinese Medicine
2016-2017
Henan University Huaihe Hospital and Huaihe Clinical Institute
2017
Soochow University
2016
First Affiliated Hospital of Soochow University
2016
Tongji Hospital
1998
To investigate mechanisms and altered pathways of gypenoside against carbon tetrachloride (CCl4)-induced liver fibrosis based on integrative analysis proteomics metabolomics data.CCl4-induced rats were administrated gypenoside. The anti-fibrosis effects evaluated by histomorphology hydroxyproline (Hyp) content. Protein profiling metabolite tissues examined isobaric tags for relative absolute quantitation (iTRAQ) approach gas chromatography-mass spectrometer (GC-MS) technology. Altered...
To investigate the epidemiological features and risk factors of HBV, HCV, syphilis infection among HIV‐infected patients in West China Hospital. A retrospective study was conducted with from 2014 to 2016 hospital, SCU. Serum makers for were detected. Among 894 patients, prevalence HIV/HBV, HIV/HCV, HIV/syphilis co‐infections 14.4%, 5.7%, 18.9% respectively. HIV/HBV/HCV, HIV/HCV/syphilis, HIV/HBV/syphilis triple co‐infection 7 (0.7%), 12(1.3%), 29(3.2%) The rate effective vaccination against...
Background M2 BPG i is a novel serum glycobiomarker of liver fibrosis. In this study, we aimed to evaluate the efficacy for predicting fibrosis and disease progression in Chinese hepatitis B virus ( HBV ) infected patients. Methods We enrolled 228 patients with different status diagnosed using FibroScan. analyzed diagnostic accuracy i, compared it AST ‐to‐platelet ratio APRI ), FIB ‐4 index, ALT AAR RDW platelet RPR ). performed receiver operating characteristics curve ROC performance...
In the United States, highest burden of chronic hepatitis B (CHB) and CHB-related liver cancer is in state California, primarily San Francisco (SF) Bay Los Angeles (LA) areas. The aim this study was to estimate county-specific surface antigen (HBsAg) prevalence quantify CHB cases by age, race/ethnicity, nativity, disease activity status.Twelve counties SF Area three large LA area were included for analysis. Race/ethnicity-specific HBsAg each county California as a whole, estimated including...
Nonsteroidal anti‑inflammatory drug‑activated gene‑1 (NAG‑1), a member of the transforming growth factor β (TGF‑β) superfamily, has been demonstrated to possess antitumorigenic and proapoptotic activities in gastric cancer cells. In present study, expression NAG‑1 was assessed human carcinoma, tumor‑adjacent normal tissues mucosa, with aim investigate role carcinogenesis development carcinoma. protein evaluated using immunohistochemical staining, while mRNA reverse transcription‑polymerase...
The hepatitis C virus (HCV) antibody assay remains the first-line screening test to identify HCV infection. newly arrived HISCL Anti-HCV had a satisfactory seroconversion sensitivity. Its sensitivity and specificity were 98.97 100% for clinical samples. In general, may be novel choice screening.
Detection of serum hepatitis B virus (HBV) markers is important for rapid screening and diagnosis HBV infection. In this study, the newly launched HISCL-5000 analyzer (Sysmex Corporation, Kobe, Japan) was appraised in parallel with MODULAR E170 (Roche Diagnostics, Penzberg, Germany), regard to detection serological China comparing evaluating their results capability.In a total 5,662 clinical samples were tested two automated systems. Among them, 1,266 assessed HBsAg, 1,000 anti-HBs, 1,301...
Introduction: Sodium taurocholate cotransporting polypeptide has been identified as the hepatitis B virus (HBV) entry receptor. However, information regarding role of sodium variants in development HBV-related advanced cirrhosis and hepatocellular carcinoma is limited.
 Methodology: Overall, 581 patients with chronic HBV infection were divided into liver fibrosis or group based on Fibrosis-4 index. Further, 183 distributed early/intermediate advanced/end stage groups Barcelona Clinic...
Objective We aim to establish the sex-related reference intervals (RIs) of PIVKA-II in southwest China by indirect method with real-world data. Methods Between 29 July 2016 and 5 February 2024, test data were collected from 120,780 healthy adult participants (aged 18 97 years) Laboratory Information System (LIS) West Hospital intervals. Additionally, a validation group comprised 2068 adults was evaluated using same detection algorithm platform. Following CLSI EP28-A3 guideline, Box-Cox...
Abstract Natural killer T (NKT) cells are amongst the most important innate immune against Hepatitis B virus (HBV) infection. Moreover, previous studies have shown that HBV infection induced TREM-1 + expression in monocyte and secretion of inflammatory cytokines. Thus, this prompted us to elucidate role monocytes regulating function NKT cells. Ninety patients 20 healthy participants were enrolled study. The percentage phenotype iNKT measured peripheral blood controls (HC), with chronic...
To provide information on clinical, virological, and molecular epidemiological characteristics for early identification, diagnosis, treatment of acute HIV infection (AHI).
Fabry disease is an X-linked genetic disorder caused by the mutations of α-galactosidase A (GLA, MIM 300644) gene presenting with various clinical symptoms including small-fiber peripheral neuropathy and limb burning pain. Here, we reported a Chinese pedigree initial diagnosis primary erythromelalgia in autosomal dominant (AD)-inherited pattern.Mutation analysis SCN9A GLA genes direct sequencing functional novel mutation cells were performed.Our data did not show any pathological gene;...
Objective A series of physiological changes in thyroid function occur during pregnancy and differ from those non-pregnant women. This study aimed to establish the pregnancy-specific reference intervals TSH FT4 using an indirect method based on healthy pregnant women southwest China population. Methods Thyroid test results which available Laboratory Information System (LIS) were collected pregnancies who visited Obstetric Clinic or Department Gynecology between 1 January 2015, 30 December...
Objective To assess the clinic application of a new-style automated immunoassay system HISCL (high sensitivity chemiluminescent enzyme immunoassay) with high sensitive chemiluminescence substrate CDP-Star®, bind-free separate technology and filter conversion technology. Methods The performance verification test evaluated HISCL's specification including reproducibility, functional sensitivity, linearity, accuracy, for HBsAg seroconversion. To evaluate specificity, 1 007 HBsAg-negative...
目的 研究分析抗乙型肝炎病毒核心抗体IgM(抗-HBc IgM)检测在乙型病毒性肝炎疫情监测中的应用，为规范乙肝报告、提高病例报告以及疫情控制准确性提供相关参考。 方法 收集2014—2016年我市疾病预防控制中心记录的、按照法定传染病报告流程要求报告的乙肝病例，对HBsAg阳性时间报告为既往未检测或结果不详或未能明确诊断为慢性的病例进行血样采集，对所有采集的血液标本进行血清抗-HBc IgM 1:1...