A5045485102- Anesthesia and Neurotoxicity Research
- Pancreatic and Hepatic Oncology Research
- Neurological Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- Microbial Natural Products and Biosynthesis
- Natural Compounds in Disease Treatment
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Flavonoids in Medical Research
- Plant pathogens and resistance mechanisms
- Neurogenetic and Muscular Disorders Research
- MicroRNA in disease regulation
First Affiliated Hospital of Wenzhou Medical University
2019-2025
Wenzhou Medical University
2019-2025
Ocean University of China
2021-2025
Guiyang Medical University
2024
Ningbo First Hospital
2023-2024
Air Force General Hospital PLA
2023
Jiangsu University of Science and Technology
2023
Beijing Tian Tan Hospital
2023
Capital Medical University
2023
Anhui Medical University
2023
Background and Purpose Renal fibrosis acts as the common pathway leading to development of end‐stage renal disease. Previous studies have shown that resveratrol has anti‐fibrotic activity, but its potential molecular mechanisms action are not well understood. Experimental Approach The effects were assayed in a rat model unilateral ureteral obstruction (UUO) vivo fibroblasts tubular epithelial cells (TECs) stimulated by TGF‐β1 vitro. Gene protein expression levels analysed PCR, Western...
Abstract Niclosamide, a cell-permeable salicylanilide, was approved by the Food and Drug Administration for its anthelmintic efficiency. A growing body of evidence in recent years suggests that niclosamide exhibits potential tumor-suppressive activity. However, role molecular mechanism pancreatic cancer remain unclear. In this study, inhibited proliferation cells (PCCs), induced apoptosis via mitochondrial-mediated pathway, suppressed cell migration invasion antagonizing...
To investigate the relationship between different body mass index (BMI) levels and vascular complications in type 2 diabetes mellitus patients.Data were collected from 3,224 individuals with (male/female: 1,635/1,589; age 61.31 ± 11.45 years), using a retrospective case study design. The association of BMI quintiles was assessed multiple logistic regression models adjusting for age, sex, duration, smoking status, drinking other confounders, those lowest quintile as reference group.With...
Abstract Background Pancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic to chemotherapy demonstrates a dilemma in clinical field. Hence, it matter great urgency develop an effective drug treat patients . Betulinic acid major triterpene isolated from spina date seed. Several studies have suggested its low toxicity and side effects malaria inflammation. However, relevant on betulinic inhibiting were insufficient molecular...
Cancer immunotherapy relies on the insight that immune system can be used to defend against malignant cells. The aim of cancer is utilize, modulate, activate, and train amplify antitumor T-cell immunity. In parallel, response damaged tissue also crucial in determining success or failure an implant. Due their extracellular matrix mimetics tunable chemical physical performance, hydrogels are promising platforms for building immunomodulatory microenvironments realizing therapy regeneration....
Calcineurin (CaN) having a high expression in hippocampal neurons is closely related to apoptosis. Pretreatment with nimodipine can lower the apoptosis rate of neuron reduce incidence postoperative cognitive dysfunction (POCD). However, relationship between cerebral protective effect pretreatment and CaN controversial literature. The aim this study evaluate neuroprotective on POCD aged rats. Ninety-six 18-month-old male Sprague-Dawley rats were randomly assigned into 4 groups (n = 24 each):...
Puerarin (8-(β-D-glucopyranosyl)-4′, 7-dihydroxyisoflavone), a natural flavonoid compound isolated from the traditional Chinese herb Radix puerariae, have been demonstrated has potential anti-tumor effects via induction of apoptosis and inhibition proliferation. However, effect molecular mechanism puerarin in pancreatic ductal adenocarcinoma (PDAC) remains unknown. In this study, tumor-suppressive were determined by both in-vitro in-vivo assays. The on proliferation, apoptosis, migration...
Fraxetin, a natural product isolated and purified from the bark of Fraxinus bungeana A.DC., has anti-inflammatory, analgesic, anti-dysenteric activities. This study aimed to investigate anti-tumor effects fraxetin in pancreatic ductal adenocarcinoma (PDA). The on malignant biological behavior PDA were evaluated. Besides, sensitivity PCCs gemcitabine, angiogenesis, epithelial-mesenchymal transition (EMT), glucose metabolism, reactive oxygen species (ROS), STAT3 activity analyzed. By reversing...
The intricate nature and varied forms of bladder urothelial carcinoma (BLCA) highlight the need for new indicators to define tumor prognosis. Disulfidptosis, a novel form cell death, is closely linked BLCA progression, prognosis, treatment outcomes. Our current goal develop disulfidptosis-related immune prognostic model enhance strategies. Utilizing RNA-seq data from Cancer Genome Atlas (TCGA) , which included 419 patients (19 normal, 400 tumor), we performed weighted gene co-expression...
Electro-acupuncture is a burgeoning treatment using the needle inserting into body acupoints and low-frequency pulse current being electrified by an electric acupuncture machine. This study was designed to evaluate effects of preconditioning electro-acupuncture on postoperative cognitive dysfunction in elderly. Ninety patients scheduled spine surgery were randomly assigned 2 groups random number table: control group (group C) EA). In EA, applied Baihui, Dazhui, Zusanli 30 minutes before...
Abstract Background Notch1 signalling is a stem-cell-related pathway that essential for embryonic development, tissue regeneration and organogenesis. However, the role of in formation myofibroblasts fibrosis kidneys following injury remains unknown. Methods The activity was evaluated fibrotic CKD patients ureteral obstructive models vivo cultured fibroblasts TECs vitro. In addition, crosstalk with TGF-β1/Smad2/3 also investigated. Results elevated rat chronic kidney disease (CKD). Further...