A5102738764- Cancer, Hypoxia, and Metabolism
- Berberine and alkaloids research
- Synthesis and Biological Activity
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Phytochemistry and Bioactive Compounds
- Phytoestrogen effects and research
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Synthesis and bioactivity of alkaloids
- Cancer therapeutics and mechanisms
- Bioactive natural compounds
- Computational Drug Discovery Methods
- Chemical Reactions and Isotopes
- ATP Synthase and ATPases Research
- Biological Activity of Diterpenoids and Biflavonoids
- Plant-derived Lignans Synthesis and Bioactivity
- Lipid metabolism and biosynthesis
- X-ray Diffraction in Crystallography
- Phytochemistry and Bioactivity Studies
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Fibroblast Growth Factor Research
- Bioactive Compounds and Antitumor Agents
Guizhou Provincial People's Hospital
2023-2025
Powerchina Huadong Engineering Corporation (China)
2024
PowerChina (China)
2024
UCLouvain
2019-2024
Xiamen Institute of Building Research Group
2023
Guiyang Medical University
2017-2022
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2016-2022
Xiamen University
2020-2021
Jiangxi University of Science and Technology
2021
Wenzhou Medical University
2013-2019
Abstract Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in absence tumor stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, molecular mechanism underlying signals remains elusive. Here, we unveil that positively charged patches (PCPs) on surface antigen-binding domain mediate clustering and result tonic signaling. For CARs with high (e.g., GD2.CAR CSPG4.CAR), reducing PCPs or boosting ionic strength culture medium...
Abstract Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known as Liquorice, widely used plant containing bioactive compounds like Glycyrrhizin, which possesses diverse medicinal properties such anti-inflammatory, antioxidant, antiviral, anticancer activities. The objective of this study to investigate the active components, relevant targets, underlying mechanisms traditional Chinese medicine...
Insulin resistance is associated with a greatly increased risk of type 2 diabetes. Administration fibroblast growth factor-1 (FGF-1) resulted in marked improvement insulin sensitivity. However, the underlying molecular mechanism whereby FGF-1 represses remains largely unknown. Here, we sought to delineate role respect its anti-inflammatory capability. In this study, found that had positive effects on glucose intolerance, hepatic lipid accumulation and resistance, while it markedly repressed...
Fraxetin, a natural product isolated and purified from the bark of Fraxinus bungeana A.DC., has anti-inflammatory, analgesic, anti-dysenteric activities. This study aimed to investigate anti-tumor effects fraxetin in pancreatic ductal adenocarcinoma (PDA). The on malignant biological behavior PDA were evaluated. Besides, sensitivity PCCs gemcitabine, angiogenesis, epithelial-mesenchymal transition (EMT), glucose metabolism, reactive oxygen species (ROS), STAT3 activity analyzed. By reversing...
Twenty-four 14-sulfonamide-tetrandrine derivatives as potential anti-cancer agents were synthesized. The synthetic investigated for their cytotoxic activity against human cancer cell lines MDA-MB-231, PC3, WM9, HEL and K562. Initially, the IC50 values (50% inhibitory concentrations) of all compounds determined. These exhibited potent, but distinct, effects on above-mentioned lines. Among them, compound 23, which was modified with a 2-naphthalenesulfonyl group at 14-amino position, showed...
Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and vitro metabolic stability. Thus, the chemical installation of BCP unit into entity remains significant challenge from synthetic point view. Here, we have presented new approach for xanthate moiety by means radical exchange process.
Twenty fangchinoline derivatives were synthesized from the natural product fangchinoline, and their anticancer activities on human breast cancer MDA-MB-231 cell line, prostate PC3 melanoma WM9 line leukaemia HEL K562 lines evaluated. The biological result showed that those exhibited potent inhibiting growth, structure-activity relationships investigated. Among them, compound 4g, which was protected by benzoyl group in 7-phenolic position nitrified 14-position, impressive inhibition all 5...
Cancer cells may stimulate glycolytic flux when O2 becomes insufficient. Increase in L-lactate release therefore appears as an escape mechanism to drugs targeting mitochondrial respiration but also represents a response that be exploited screen for compounds blocking either carriers of oxidizable substrates or the electron transport chain. Here, we developed screening procedure based on capacity cancer gain insights development complex I inhibitors. For this purpose, synthesized derivatives...
Two new flavones, 6,7-methylenedioxy-4-hydroxypeltogynan-7'-one (1), cochliophilin B (2), as well two known ones, A (3) and 6-methoxy-7-hydroxy flavone (4), were isolated from the ethanol extract of root Phytolacca acinosa Roxb. Compound 1 is a flavanol framework with one δ-lactone unit, which rather rare in nature. The structures compounds determined on basis extensive spectroscopic (IR, MS, 1D- 2D-NMR) analyses, absolute configuration was established by comparing experimental calculated...
Two new flavonoids, 1 and 2 , together with two known tephrosin ( 3 ) 12a‐hydroxy‐ α ‐toxicarol 4 ), were isolated from the whole herb of Derris eriocarpa How . The structures absolute configurations compounds elucidated on basis their MS NMR ECD data. established by extensive spectroscopic 1D‐ 2D‐ analyses comparison literature All D for first time. Compound showed modest inhibitory activities against growth human cancer cells HEL A549 IC 50 values 15.03 ± 0.62 13.27 0.39 μ m respectively.
Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC). Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available HCC.To investigate the effects of a fangchinoline derivative HL23, novel HDACi its molecular mechanisms through TXNIP-mediated potassium deprivation HCC.Both vitro assays orthotopic HCC mouse models were used to HL23 this study. The...
Background: Acute necrotizing pancreatitis is a serious pancreatic injury with limited effective treatments. This study aims to investigate the therapeutic effects of hesperidin on Larginine- induced acute and its potential targets. Methods: The authors in mice by administering two hourly intraperitoneal injections L-arginine-HCl, evaluated impact lung tissues, plasma amylase activity, myeloperoxidase content. Additionally, necrosis mitochondrial function was tested primary acinar cells....
Ethnopharmacological relevance: Two types of traditional Chinese formulas botanical drugs are prescribed for treating perimenopausal syndrome (PMS), a disorder in middle-aged women during their transition to menopause. One is PMS as kidney deficiency (KD) due senescence and declining reproductive functions, the other it liver qi stagnation (LQS) association with stress anxiety. Despite time-tested prescriptions, an objective attestation effectiveness treatment still be established associated...
The 46th EuroCongress on Drug Synthesis and Analysis (ECDSA-2017) was arranged within the celebration of 65th Anniversary Faculty Pharmacy at Comenius University in Bratislava, Slovakia from 5–8 September 2017 to get together specialists medicinal chemistry, organic synthesis, pharmaceutical analysis, screening bioactive compounds, pharmacology drug formulations; promote exchange scientific results, methods ideas; encourage cooperation between researchers all over world. topic conference,...
Hepatocellular carcinoma (HCC), the most common malignancy of liver, exhibits high recurrence and metastasis. Structural modifications natural products are crucial resources antitumor drugs. This study aimed to synthesize C-14 derivatives tetrandrine evaluate their effects on HCC. Forty sulfonate were synthesized in vitro antiproliferative was evaluated against four hepatoma (HepG-2, SMMC-7721, QGY-7701, SK-Hep-1) cell lines. For all tested cells, modified compounds more active than lead...