A5101492326- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Tuberculosis Research and Epidemiology
- Urinary and Genital Oncology Studies
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Nanowire Synthesis and Applications
- CAR-T cell therapy research
- Pancreatic function and diabetes
- Clinical Nutrition and Gastroenterology
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Dietetics, Nutrition, and Education
- Stoma care and complications
Xi'an Chest Hospital
2015-2024
Kunming Medical University
2024
Northeast Forestry University
2023
ShanghaiTech University
2020-2023
Xi'an Jiaotong University
2022-2023
Qingdao University
2021-2022
Affiliated Hospital of Qingdao University
2021-2022
Seoul National University
2008-2021
Pfizer (United States)
2020-2021
China Pharmaceutical University
2021
Abstract Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in absence tumor stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, molecular mechanism underlying signals remains elusive. Here, we unveil that positively charged patches (PCPs) on surface antigen-binding domain mediate clustering and result tonic signaling. For CARs with high (e.g., GD2.CAR CSPG4.CAR), reducing PCPs or boosting ionic strength culture medium...
Much attention has been paid to conversion therapy for stage IV gastric cancer, however, its operative comorbidities and survival benefit have not yet clarified. CONVO-GC-1, an international retrospective cohort study, was designed investigate the role of surgery in Japan, Korea, China. The rate complications primary endpoint overall (OS), according four-category criteria previously published (Gastric Cancer:19; 2016), analyzed as secondary endpoint. A total 1206 patients underwent after...
Abstract The initial development of diffuse gastric cancer (DGC) is poorly understood. study E-cadherin (CDH1) germ line mutation carriers predisposed to DGC provides a rare opportunity elucidate the genetic and biological events surrounding disease initiation. Samples from various stages hereditary sporadic were investigated determine general mechanisms underlying early development. Paraffin-embedded tissues 13 CDH1 10 cases analyzed. Immunofluorescence immunohistochemistry using...
Tumor associated macrophages are major inflammatory cells that play an important role in the tumor microenvironment. In this study, we investigated prognostic significance of (TAMs) MSI-high gastric cancers using immunohistochemistry. CD68 and CD163 were used as markers for total infiltrating M2-polarized macrophages, respectively. The density CD68+ or CD163+ TAMs four different areas (epithelial stromal compartments both center invasive front) analyzed 143 cases advanced a computerized...
Mycobacterium tuberculosis (MTB) identification and drug resistance diagnosis are very important for treatment of drug-resistant (DR-TB). Therefore, high throughput, accurate low-cost molecular detection techniques urgently needed. This study aimed to evaluate the clinical application value MassARRAY in screening.The limit (LOD) were evaluated using reference strains isolates. MTB bronchoalveolar lavage fluid (BALF) sputum samples detected MassARRAY, quantitative real-time polymerase chain...
Results of 6589 gastric cancer operations at the Department Surgery, Seoul National University Hospital, from 1970 to 1990 were reported. About two thirds (76.6%) advanced (stages III and IV). The 5-year survival rate operated stage was only 30.6%, with frequent recurrence. Conversely, cell-mediated immunities patients significantly decreased. Therefore, improve cure prevent or delay recurrence, curative surgery confirmation free resection margins systematic lymph node dissection perigastric...
For an antibody to be a successful therapeutic many competing factors require optimization, including binding affinity, biophysical characteristics, and immunogenicity risk. Additional constraints may arise from the need formulate antibodies at high concentrations (>150 mg/ml) enable subcutaneous dosing with reasonable volume (ideally <1.0 mL). Unfortunately, exhibit viscosities that place impractical (such as multiple injections or large needle diameters) on delivery impede efficient...
The aim of this study was to evaluate how programmed death-ligand-1 (PD-L1) expression is linked the immunoscore in context tumor microenvironment and assess differential prognostic value PD-L1 according 153 patients with microsatellite instability-high (MSI-H) advanced gastric cancer (GC).We found that T-PD-L1 (+) I-PD-L1 were significantly associated a high immunoscore. integrated immune cells not correlated overall survival (OS) patients. However, combined analysis revealed four distinct...
OBJECTIVE. We hypothesized that performing CT gastrography with the patient in left posterior oblique (LPO) position would provide better distention and less residual fluid for lower part of stomach than standard supine position.
Pulses, including dried peas, are nutrient- and fibre-rich foods that improve glucose control in diabetic subjects compared with other fibre sources. We hypothesized feeding cooked pea seed coats to insulin-resistant rats would tolerance by modifying gut responses reducing stress on pancreatic islets. Glucose intolerance induced male Sprague-Dawley high-fat diet (HFD; 10% cellulose as fibre) was followed 3 weeks of HFD (10%) provided cellulose, raw-pea coat (RP), or cooked-pea (CP). A fourth...
Robot-assisted laparoscopic surgery offers several advantages compared with open and conventional minimally invasive surgery. However, one issue that needs to be resolved is a collision between the robot arm assistant instrument. This mostly caused by miscommunication surgeon assistant. To resolve this limitation, an surgical system can simultaneously manipulated via wireless controller proposed allow control The comprises two novel master interfaces (NMIs), instrument gripper actuated...
To assess the diagnostic performance of multidetector-row computed tomography (CT) 3-dimensional CT gastrography (3-D CTG) to detect early gastric cancer (EGC) compared with axial images alone.Contrast-enhanced scanning was performed on 39 patients histopathologically proven EGC. By using volume-rendering technique, CTG were created and interval reviews both without 3-D independently by 2 radiologists retrospectively. The stomach divided into 4 segments (ie, cardia or fundus, body, angle,...
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for treatment solid tumors. Using combination hybridoma, phage display rational design protein engineering, we have developed fully humanized manufacturable CD3 that demonstrates favorable pharmacokinetic properties potent in vivo efficacy. Anti-GUCY2C antibodies derived from mouse hybridomas were first into well-behaved human variable region frameworks with full retention...
With the application of bedaquiline (Bdq), success rate multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, cardiac safety patients during cannot be ignored. Hence, this study compared effects alone and combined with fluoroquinolones (FQs) and/or clofazimine (CFZ) on QT interval. This single-center retrospective cohort analyzed clinical data MDR-TB treated for 24 weeks from January 2020 to May 2021 in Xi'an Chest Hospital changes QTcF between two...
The volume-rendering technique uses computed tomography data to produce simulated images of conventional barium and endoscopic studies the stomach. Various gastric lesions are detected on volume-rendered images, submucosal tumors easily differentiated from mucosal by means overlying bridging fold. Lesions that only manifested a change color (early cancer type 2b) or loss detail (gastritis) difficult detect however. In cases neoplasm varix, both extraluminal pathologies lesion relation...
This study aimed to evaluate the efficacy of post-operative oral nutrition supplementation after major gastrointestinal surgery.A prospective randomized controlled trial was conducted 174 subjects who were discharged within 2 weeks surgery. The in group prescribed 400 ml/day Encover® from day discharge for 8 weeks, but no allowed control group. primary endpoint weight loss rate at compared with pre-operative weight, and secondary endpoints included changes body mass index, Patient-Generated...