A5100401314- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Soft tissue tumor case studies
- Pancreatic function and diabetes
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Phosphodiesterase function and regulation
- Pluripotent Stem Cells Research
- High Altitude and Hypoxia
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Microtubule and mitosis dynamics
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- BRCA gene mutations in cancer
- Williams Syndrome Research
Beijing University of Chinese Medicine
2025
Hainan University
2025
Liaoning University
2024
Air Force Medical University
2015-2024
Xijing Hospital
2006-2024
Air Force General Hospital PLA
2020-2021
Chinese People's Liberation Army
2021
Shanxi Medical University
2021
Second Hospital of Shanxi Medical University
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2012-2018
Abstract Metachronous liver metastases (MLM) are characterised by high incidence and mortality in clinical colorectal cancer treatment. Currently traditional methods cannot effectively predict prevent the occurrence of metachronous metastasis cancer. Based on 5hmC‐Seal analysis blood tissue samples, this study found that portal venous was more relevant to tumour gDNA than peripheral blood. We performed a novel epigenetic liquid biopsy strategy using 10 5hmC alterations, accurately...
Background Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and therefore readily consumed by humans. The relationship between their chemical structure intestinal absorption, transport, first-pass metabolism remains unresolved, however. Methods Here, we investigated absorption four polyphenol apigenin, resveratrol, emodin chrysophanol, using in vitro Caco-2 cell monolayer model system situ perfusion vivo pharmacokinetic...
Abstract Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport over long range, its physiological roles outside are largely elusive 1,2 . Here we found chondrocytes produced massive amounts form eosin-positive bodies their cytoplasm. The body (Hedy) membraneless condensate characterized by phase separation. Production controlled hypoxia and dependent on KLF1 rather than the HIF1/2α pathway. Deletion leads Hedy loss along with severe hypoxia, enhanced...
JMJD3 (KDM6B) is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. However, the function of in vivo not well understood. Here we show that highly expressed cells chondrocyte lineage, especially prehypertrophic hypertrophic chondrocytes, during endochondral ossification. Homozygous deletion Jmjd3 results severely decreased proliferation delayed hypertrophy thereby marked retardation ossification mice. Genetically, associates with RUNX2 to promote...
Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis new cell death and characterized by the dependence on mitochondrial respiration protein lipoylation. However, potential roles cuproptosis-related genes (CRGs) in ESCA remain elusive. Here, we systematically assessed transcriptional genetic alterations CRGs ESCA. We identified signature for patients. A 6-CRGs was constructed least absolute shrinkage selection operator (LASSO) regression analysis along...
Abstract Background Exosomes are known to transmit microRNAs (miRNAs) affect cancer progression, while the role of M2 macrophages-derived exosomes (M2 exosomes) conveying miR-501-3p in lung (LC) remains unknown. We aim explore exosomal LC development via targeting WD repeat domain 82 (WDR82). Methods Lung tissue and normal specimens were collected, which tumor-associated macrophages (TAM) measured by immunohistochemistry. induced treated with altered miR-501-3p, then extracted identified....
Psoriasis is a complex chronic inflammatory disease that severely affects the quality of life patients. However, current medications could only control symptoms but not cure psoriasis with unmet medical needs. Herein, structure-based optimizations natural product moracin M (IC50 2.9 μM) led to novel PDE4 inhibitor L30 greatly improved potency 8.6 nM) and remarkable selectivity across other PDEs families (>201-fold). The binding pattern revealed by cocrystal structure was different from...
// Feng Zhang 1,* , Xutao Jin Meng 2,3,* Yong Zhao 4 Xinli Liu 1 Yanxia 5 Yukun Wang Yuhua Li Yang Sun Zhipeng Qibing Mei and Tao 6 Key Laboratory of Gastrointestinal Pharmacology Chinese Materia Medica the State Administration Traditional Medicine, Department Pharmacology, School Pharmacy, Fourth Military Medical University, Xi’an, China 2 Oncology, Tangdu Hospital, The 3 No. 309 Hospital PLA, Beijing, Animal Center, National Engineering Center for Biochip, Shanghai, Thoracic Surgery,...
Abstract Currently, the reliable prognostic biomarkers for WHO grade II diffuse astrocytomas (DA) are still limited. We investigated relations between level of 5-Hydroxymethylcytosine (5hmC), an oxidated production 5-methylcytosine (5mC) by ten eleven translocated (TET) enzymes, and clinicopathological features glioma patients. With identified anti-5hmC antibody, we performed immunohistochemistry in 287 cases. detected that 5hmC variably reduced most gliomas reduction was closely associated...
Isocitrate dehydrogenase (IDH) mutations occur frequently in lower-grade gliomas, which result genome-wide epigenetic alterations. The wild-type IDH1 is reported to participate lipid biosynthesis and amino acid metabolism, but its role tumorigenesis still unclear. In this study, the expressions of podoplanin (Pdpn) were determined IDH-mutated IDH-wild-type their relationships glioma further analyzed. addition, regulation mutant on Pdpn expression was investigated by luciferase assays...
ING5 belongs to the Inhibitor of Growth (ING) candidate tumor suppressor family. Previously, we have shown that inhibits invasiveness lung cancer cells by downregulating EMT-inducing genes. However, underlying mechanisms remain unclear. The aim study was use integrated approach involving SILAC labeling and mass spectrometry-based quantitative proteomics quantify dynamic changes acetylation regulated in cells. Here, found has a profound influence on protein lysine with 163 peptides 122...
Increasing evidence has indicated that mutations of isocitrate dehydrogenase 1/2 (IDH1/2) contribute to the metabolic reprogramming cancer cells; however their functions in lipid metabolism remain unknown. In present study, parental and IDH1 (R132H/+) mutant HCT116 cells were treated with various concentrations oleic acid (OA) or palmitic (PA) presence absence glucose. The results demonstrated mutation exacerbated effects OA PA on cell viability apoptosis, consistently elevated production...
Metastasis is the principal cause of morbidity and mortality in cancer patients. The master genes that govern organ-selective metastasis remain elusive. We compared expression levels C-X-C chemokine receptor type 4 (CXCR4) human small cell lung (SCLC) cells, SBC-5 SBC-3, by flow cytometric analysis found CXCR4 was expressed at markedly higher cells which can produce multiple organ metastasis, particularly bone to SBC-3 cells. Stromal-derived-factor-1 (SDF-1)-CXCR4 has been shown regulate...
Abstract Cytoskeletal reorganization is essential to keratinocyte function. Rac1 regulates cytoskeletal through signaling pathways such as the cofilin cascade. Cofilin severs actin filaments after activation by dephosphorylation. was knocked out in mouse keratinocytes and it found that disassembled. In epidermis of mice which only keratinocytes, phosphorylation aberrantly elevated, corresponding repression phosphatase slingshot1 (SSH1). These effects were independent for p21‐activated...