A5071407293- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
- Spinal Cord Injury Research
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Light effects on plants
- Molecular Biology Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Drug Transport and Resistance Mechanisms
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Muscle Physiology and Disorders
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jinzhou Medical University
2022-2025
Linyi People's Hospital
2023
Southwest Medical University
2023
Shaanxi Provincial People's Hospital
2023
Sichuan University
2022
Second Affiliated Hospital of Xi'an Jiaotong University
2022
Shanghai University of Traditional Chinese Medicine
2020-2022
Summary Target of Rapamycin ( TOR ) is a positive regulator growth and development in all eukaryotes, which positively regulates anabolic processes like protein synthesis, while repressing catabolic processes, including autophagy. To better understand function we decided to analyze its role seed germination. We therefore performed detailed phenotypic analysis using mutants the REGULATORY ‐ ASSOCIATED PROTEIN OF 1B RAPTOR ), conserved interactor, acting as scaffold protein, recruits...
Abstract Thyroid nodules can be classified into benign and malignant tumors. However, distinguishing between these two types of tumors challenging in clinics. Since require surgical intervention whereas asymptomatic do not, there is an urgent need for new techniques that enable accurate diagnosis thyroid nodules. Here, we used 1 H NMR spectroscopy coupled with pattern recognition to analyze the metabonomes tissues their extracts from lesion patients (n = 53) adjacent healthy 46). We also...
Abstract The diagnosis of malignant tumors is essential for informing clinical decisions regarding therapeutic options. Current imaging and pathological diagnostic methods do not provide quantitative molecular information that important in tumor identification. Moreover, tissue analysis dependent on unevenly distributed features. microenvironment has been documented to have hydrogen peroxide (H 2 O ). This study presents a biologically sensitive efficient H electrochemical sensor based PtNi...
Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis new cell death and characterized by the dependence on mitochondrial respiration protein lipoylation. However, potential roles cuproptosis-related genes (CRGs) in ESCA remain elusive. Here, we systematically assessed transcriptional genetic alterations CRGs ESCA. We identified signature for patients. A 6-CRGs was constructed least absolute shrinkage selection operator (LASSO) regression analysis along...
Abstract Background Mesenchymal stem cells (MSCs) are a well-established immunomodulatory agent which can also promote tissue repair and regeneration. Recent studies have demonstrated MSCs as novel therapeutic for inflammatory bowel disease (IBD), chronic idiopathic disorder of the gastrointestinal tract. However, precise role in regulating immune responses is controversial, its significance pathogenesis remains IBD undefined. In addition, MSCs’ acellular product, extracellular vesicles...
Abstract Background Solute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is lowly expressed in ovarian and hepatocellular cancers, which associated with their worse prognosis. However, its roles the prognosis, drug resistance immune infiltration non-small-cell lung cancer (NSCLC) are unclear. Methods We chose SLC7A2 from RNA-Seq of paclitaxel/cisplatin-resistant A549 cells, then bioinformatics, cell lines construction, RT-qPCR, CCK8 were performed to investigate...
Abstract Background Gastric cancer (GC) has an unwelcoming prognosis when diagnosed at advanced stage. The purpose of this study was to examine the expression myosin heavy chain 11 (MYH11) in GC and mechanisms related. Methods MYH11 investigated via SangerBox platform. tissues cell lines examined by immunohistochemistry, RT-qPCR, western blot. relationship between patients’ analyzed. effects on biological behaviors cells were gain-of-function experiments. Bioinformatics analysis used find...
Periodontitis is a risk factor for the development of oral squamous cell carcinomas (OSCC). Both DNA damage response (DDR) and activation inflammasomes induced by microbiome might play important roles in tumors, relation to genome stability tumor cells. Herein, we explored whether periodontitis negative-associated bacteria (Neisseria sicca Corynebacterium matruchotii, namely called 'PNB'), which were highly abundant healthy populations, could inhibit OSCC promoting stability. Firstly, murine...
As the crosstalk between metabolism and antitumor immunity continues to be unraveled, we aim develop a prognostic gene signature that integrates lipid immune features for patients with lung adenocarcinoma (LUAD). First, differentially expressed genes (DEGs) related in LUAD were detected, subgroups of identified via unsupervised clustering method. Based on immune-related DEGs, variables determined by univariate Cox LASSO regression, was established. The value evaluated Kaplan-Meier method,...
Abstract Background Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein (Ufbp1), as putative targets of ubiquitin-fold modifier (Ufm1), have been implicated in several pathogenesis-related signaling pathways. However, little is known about their functional roles liver disease. Methods Hepatocyte-specific Ufl1 Δ/Δhep Ufbp1 mice were used to study role injury. Fatty disease cancer induced by high-fat diet (HFD) diethylnitrosamine (DEN) administration, respectively. iTRAQ analysis was...
Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress-related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms risk of lung cancer. Methods: Six single-nucleotide (SNPs) EIF2AK3, HSPA5, DDIT3 were genotyped in 620 cases controls using a MassARRAY platform. Results: The minor allele A rs6750998 was protective against cancer (p < 0.001), while alleles rs867529, rs391957, rs697221 all that may lead multiplied disease (rprs867529 = 0.002;...
HNRNPM is reported to be involved in multiple malignancies, while the prognostic and biological role of hepatocellular carcinoma remains still unknown.Public databases tissue microarrays were employed identify expression pattern value carcinoma. CCK8, cell migration assays western blot taken advantage discover Western bioinformatics analysis used reveal potential signaling pathways carcinoma.High was proved a poor independent factor for overall survival (OS) patients. Tissue...
Ovarian serous cystadenocarcinoma (OSC), a common gynecologic tumor, is characterized by high mortality worldwide. Bromodomain (BRD)-containing proteins are series of evolutionarily conserved that bind to acetylated Lys residues histones regulate the transcription multiple genes. The ectopic expression BRDs often observed in cancer types, but role OSC still unclear.We performed differential expression, GO enrichment, GSEA, immune infiltration, risk model, subtype classification, stemness...
Skin cutaneous melanoma (SKCM) is one of the most malignant skin cancers and remains a health concern worldwide. Pyroptosis newly recognized form programmed cell death plays vital role in cancer progression. We aim to construct prognostic model for SKCM patients based on pyroptosis-related genes (PRGs). from The Cancer Genome Atlas (TCGA) were divided into training validation cohorts. used GSE65904 downloaded GEO database as an external cohort. performed Cox regression least absolute...