A5102872956- Cancer, Hypoxia, and Metabolism
- Oil Spill Detection and Mitigation
- Methane Hydrates and Related Phenomena
- Atmospheric and Environmental Gas Dynamics
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Sepsis Diagnosis and Treatment
- Milk Quality and Mastitis in Dairy Cows
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Constructed Wetlands for Wastewater Treatment
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Wastewater Treatment and Nitrogen Removal
- Nuclear Receptors and Signaling
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- interferon and immune responses
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Apelin-related biomedical research
Emory University
2023-2025
Nanjing Agricultural University
2017-2025
First Affiliated Hospital of Gannan Medical University
2015-2024
Southwest University
2023-2024
Hangzhou First People's Hospital
2016-2024
Lanzhou University
2023-2024
Westlake University
2024
Delaware River Basin Commission
2024
Zhejiang University
2018-2023
Jiangsu University of Science and Technology
2023
Acute kidney injury (AKI) is a common complication in critically ill patients with sepsis and often associated poor prognosis. We aimed to construct validate an interpretable prognostic prediction model for sepsis-associated AKI (S-AKI) using machine learning (ML) methods.
A model developed to simulate the behavior of oil and gas accidentally released from deep water is presented. This presents major modifications a three-dimensional earlier (Yapa Zheng, 1997) that behaviour under accidents (shallow water). In deepwater, ultra-high pressure cold temperature causes phase changes in gases. These combined with relatively strong currents some deepwater regions extraordinary challenges modeling jets/plumes blowouts. The present incorporates gas, associated...
Calcium nanoparticles have been investigated for applications, such as drug and gene delivery. Additionally, Ca2+ serves a crucial second messenger in the activation of immune cells. However, few studies systematically studied effects calcium on levels functions within In this study, we explore potential vehicle to deliver into cytosol dendritic cells (DCs) influence their functions. We synthesized hydroxide nanoparticles, coated them with layer silica prevent rapid degradation, further...
Glycolytic metabolism may account for antitumor immunity failure. Pyruvate kinase M2 (PKM2) and platelet phosphofructokinase (PFKP), two key enzymes involved in the glycolytic pathway, are hyperactivated head neck squamous cell carcinoma (HNSCC). Using ganetespib as a drug model heat shock protein 90 (HSP90) inhibition combining results from clinical trials animal treatment, we demonstrated that HSP90 leads to blockade of flux HNSCC cells by simultaneously suppressing PKM2 PFKP at both...
The multi-therapy modality is based on the combination and synergy of multiple single treatment modalities materials chemistry.
Rheumatoid arthritis is a chronic immunological disease leading to the progressive bone and joint destruction. Angiogenesis, accompanied by synovial hyperplasia inflammation underlies Delaying or even blocking angiogenesis has emerged as an important target of RA treatment. Natural medicines long history treating RA, numerous reports have suggested that natural strong inhibitory activity on angiogenesis, thereby improving progression RA. could regulate following signaling pathways:...
Abstract Background While T cell-activating immunotherapies against recurrent head and neck squamous cell carcinoma (HNSCC) have shown impressive results in clinical trials, they are often ineffective the majority of patients. NK cells potential targets for immunotherapeutic intervention; however, setback monalizumab-based therapy HNSCC highlights need an alternative treatment to enhance their antitumor activity. Methods Single-cell RNA sequencing (scRNA-seq) TCGA datasets were used identify...
A companion paper (Part I-Zheng et al., 2003) presents the development and module tests of a model, CDOG, developed to simulate behavior oil gas accidentally released from deepwater. CDOG model incorporates phase changes gas. associated in thermodynamics its impact on hydrodynamics jet/plume. Hydrate formation, hydrate decomposition, dissolution, non-ideal gas, possible separation main plume due strong cross currents are integrated with jet/plume thermodynamics. In this paper. is used...
Abstract Background Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein (Ufbp1), as putative targets of ubiquitin-fold modifier (Ufm1), have been implicated in several pathogenesis-related signaling pathways. However, little is known about their functional roles liver disease. Methods Hepatocyte-specific Ufl1 Δ/Δhep Ufbp1 mice were used to study role injury. Fatty disease cancer induced by high-fat diet (HFD) diethylnitrosamine (DEN) administration, respectively. iTRAQ analysis was...
This paper presents a detailed analysis of different deepwater blowout scenarios using the Clarkson oil and gas model (CDOG). In CDOG, hydrate formation, decomposition, dissolution, nonideal behavior gas, possible separation from main plume due to strong cross-currents, are integrated with jet/plume hydrodynamics thermodynamics. CDOG takes into account unsteady-state three-dimensional variation ambient currents density stratification. Detailed comparisons between simulations deepspill field...
We reported the synthesis of a tris(triazolylmethyl)amine (TTA)-bridged organosilane, functioning as Cu(I)-stabilizing ligands, and installation this building block into backbone mesoporous organosilica nanoparticles (TTASi) by sol–gel way. Upon coordinating with Cu(I), CuI-TTASi, restricted metal active center inside pore, functions molecular-sieve-typed nanoreactor to efficiently perform Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions on small-molecule substrates but fails...
Abstract Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. Methods We explore approach that enables induction through external radiation. The key component of this technology 7-dehydrocholesterol (7DHC), natural biosynthetic precursor cholesterol. To facilitate delivery, we demonstrate 7DHC, like cholesterol, can be incorporated into the layer liposomes....
Abstract CDK5RAP3 is a binding protein of CDK5 activating proteins and also one the key co-factors E3 enzyme in UFMylation system. Several reports have implicated involvement other components system neuronal development multiple psychiatric disorders. However, precise role neurons remains elusive. In this study, we generated neuron-specific knockout mice (CDK5RAP F/F : Nestin-Cre). conditional (CDK5RAP3 CKO) exhibited severe encephalo-dysplasia slower developmental trajectory compared to...
The tricarboxylic acid (TCA) cycle, occurring within the mitochondrial matrix, plays a pivotal role in metabolism, which is essential for generating energy to support tumor cell proliferation and survival. CPI-613 (devimistat) novel systemic therapeutic that targets TCA cycle by inhibiting pyruvate dehydrogenase (PDH) through hyperactivation of its regulatory kinases inducing reactive oxygen species (ROS)-mediated inhibition ketoglutarate (KGDH). Here we report mechanism potentiates...
Abstract Metastasis is the leading cause of cancer-related morbidity and mortality. The lung second most common site metastasis. It estimated that 20 to 54% malignant tumors develop elsewhere in body will have pulmonary metastases. However, limiting metastatic tumor growth progression remains a significant bottleneck. ATAD3A, mitochondrial-localized protein, has been shown play critical role maintaining survival lung. current challenge lies genetically depleting ATAD3A tumors. Among various...
Abstract Despite significant advances, the limited therapeutic efficacy of virotherapy remains a major hurdle in use oncolytic viruses (OVs) for cancer treatment. To overcome this challenge, we integrated SMAC/DIABLO gene into genome vesicular stomatitis virus (VSV) to create new generation VSV, termed VSV-S. In study, infected head and neck squamous cell carcinoma (HNSCC) cells tumors with VSV-S evaluate its underlying mechanisms. exhibited significantly enhanced antitumor activity HNSCC...
Abstract The tricarboxylic acid (TCA) cycle is often rewired or dysregulated to meet the increased energy and biosynthetic demands of rapidly dividing cancer cells, targeting TCA a potential therapeutic strategy for treating cancer. However, tumor cell metabolism can impact other cells in microenvironment, disrupting could antitumor immune response. In this study, using CPI-613 as model drug inhibition, we identified molecular mechanism by which blocking enhances T-cell–mediated immunity...
Oil released in a deepwater blowout breaks up into droplets. Hence, the time it takes for oil to reach water surface, its location, and size of surface slick at given time, are all affected by droplet sizes. Information on surfacing essential emergency spill response as well contingency planning. Despite importance fate many problems, our ability estimate sizes has been poor. In this paper, methods developed model distribution generated due an accidental release. Models estimating release...