A5035331102- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Heat shock proteins research
- RNA modifications and cancer
- Circular RNAs in diseases
Emory University
2022-2024
Glycolytic metabolism may account for antitumor immunity failure. Pyruvate kinase M2 (PKM2) and platelet phosphofructokinase (PFKP), two key enzymes involved in the glycolytic pathway, are hyperactivated head neck squamous cell carcinoma (HNSCC). Using ganetespib as a drug model heat shock protein 90 (HSP90) inhibition combining results from clinical trials animal treatment, we demonstrated that HSP90 leads to blockade of flux HNSCC cells by simultaneously suppressing PKM2 PFKP at both...
Intensity-modulated radiation therapy (IMRT) reirradiation of nonmetastatic recurrent or second primary head and neck squamous cell carcinoma (HNSCC) results in poor progression-free survival (PFS) overall (OS).
Anti-programmed cell death protein 1 (PD-1) therapy is a standard of care in recurrent and/or metastatic head and neck squamous carcinoma (RMHNSCC). Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) have immunomodulatory properties improve clinical outcomes combination with anti-PD-1 different malignancies. We report the long-term efficacy safety pembrolizumab cabozantinib patients RMHNSCC include correlative biomarker analysis.
6008 Background: Pembrolizumab (pembro) is an immune checkpoint inhibitor (ICI) approved for treating pts with recurrent/metastatic (RM) HNSCC. Cabozantinib (cabo) a multiple receptor tyrosine kinase (TKI) targeting MET and VEGFR2 shown to reduce tumor growth, metastasis, angiogenesis has immuno-modulatory properties. Methods: This phase II, open label multi-center, single arm trial evaluating the tolerability clinical benefit of pembro administered at 200 mg every 3 weeks cabo 40 daily RM...
Abstract Background The purpose of this study was to provide further insights into whether age and/or sex are associated with prognosis in oral tongue squamous cell carcinoma. Methods This a retrospective cohort utilizing hospital registry data from 2006 2016 obtained the National Cancer Database. Identified patients were divided various cohorts based on age, sex, and staging. A descriptive analysis performed using chi‐square tests overall survival rates estimated Kaplan–Meier method....
Abstract Accumulating evidence suggests that failure of antitumor immunity may be due to dysregulation energy metabolism. Head and neck squamous cell carcinoma (HNSCC) exhibits increased activity two key enzymes, pyruvate kinase M2 (PKM2) platelet phosphofructokinase (PFKP), which are central the glycolytic pathway responsible for conversion glucose ATP energy. HSP90 is a molecular chaperone plays critical role in folding, stabilization, regulation wide range client proteins involved various...
<div>AbstractPurpose:<p>Anti-programmed cell death protein 1 (PD-1) therapy is a standard of care in recurrent and/or metastatic head and neck squamous carcinoma (RMHNSCC). Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) have immunomodulatory properties improve clinical outcomes combination with anti-PD-1 different malignancies. We report the long-term efficacy safety pembrolizumab cabozantinib patients RMHNSCC include correlative biomarker...
e14713 Background: Immune checkpoint inhibitor (ICI) therapy (pembrolizumab monotherapy and pembrolizumab combined with platinum-based chemotherapy) is recommended as first line for patients PD-L1 positive advanced or metastatic non-small cell lung cancer (NSCLC) without actionable biomarkers due to incredible improvements in overall survival (OS). Despite this, 15-20% of do not respond ICI NSCLC. This study examines the effect body composition features, via analytic morphomics, conjunction...