A5089460717- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ear and Head Tumors
- Hepatocellular Carcinoma Treatment and Prognosis
- Management of metastatic bone disease
- Nonmelanoma Skin Cancer Studies
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Oral Health Pathology and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Colorectal and Anal Carcinomas
- Breast Implant and Reconstruction
- Cutaneous Melanoma Detection and Management
- Thyroid Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Radiation Dose and Imaging
- Tracheal and airway disorders
Cleveland Clinic
2016-2025
Cancer Institute (WIA)
2020
Cleveland Foundation
2016
Jacobs (United States)
2008
Mount Sinai Hospital
2007
Lunenfeld-Tanenbaum Research Institute
2007
Stereotactic body radiation therapy (SBRT) is the standard of care for medically inoperable patients with early-stage NSCLC. However, NSCLC composed several histological subtypes and impact this heterogeneity on SBRT treatments has yet to be established.We analyzed 740 treated definitively from 2003 through 2015. We calculated cumulative incidence curves using competing risk method identified predictors local failure Fine Gray regression.Overall, 72 had a failure, at 3 years 11.8%. On...
Survival outcomes for anaplastic thyroid cancer (ATC), the most aggressive subtype of cancers, have remained poor. However, targeted therapies and immunotherapies present new opportunities treatment this disease. Evaluations survival over time with multimodal are needed optimizing plans.
Abstract Background Patients with locally advanced or recurrent rectal cancer often require multimodality treatment. Intraoperative radiation therapy (IORT) is a focal approach which aims to improve local control. Methods We retrospectively reviewed 42 patients treated IORT following definitive resection of from 2000–2009. All were the Intrabeam® Photon Radiosurgery System (PRS). A dose 5 Gy was prescribed depth 1 cm (surface range: 13.4-23.1, median: 14.4 Gy). Median survival times...
Intensity-modulated radiation therapy (IMRT) reirradiation of nonmetastatic recurrent or second primary head and neck squamous cell carcinoma (HNSCC) results in poor progression-free survival (PFS) overall (OS).
Shc family proteins serve as phosphotyrosine adaptor molecules in various receptor-mediated signaling pathways. In mammals, three distinct genes have been described that encode characterized by two phosphotyrosine-interaction modules, an amino-terminal binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Here, we report the analysis of uncharacterized fourth protein, ShcD/Shc4, is expressed adult brain skeletal muscle. Consistent with this expression pattern, find ShcD can...
There are limited data regarding survival, failure patterns, and factors associated with disease recurrence in patients cutaneous squamous cell cancer of the head neck (cSCC-HN) nodal metastases.A retrospective analysis cSCC-HN metastatic to cervical and/or parotid lymph nodes treated surgery post-operative radiation therapy was performed.This study included 76 (57 immunocompetent 18 immunosuppressed) a median follow-up months. Overall disease-free survival (DFS), (DR) at 2 years 60%, 49%,...
Objective Organ preservation (OP) treatment for advanced laryngeal cancer has increased compared to primary total laryngectomy. Our study compares oncologic and functional outcomes between these approaches. Study Design Retrospective cohort study. Setting Single tertiary care institution. Methods review of patients receiving laryngectomy or OP 1/1/2000 12/31/2018. Results A 118 received 119 OP. Overall survival was similar When stratified by T stage, disease‐free worse among T3 versus In...
ABSTRACT Introduction Salivary gland malignancies are heterogeneous tumors with highly variable outcomes. Elective neck management options include observation, dissection (ND), and irradiation (NI). We sought to compare outcomes of cN0 salivary cancer by elective management. Methods An IRB‐approved registry was queried for cancers categorized based on into ND, NI, ND + NI groups. included no evidence clinical or radiographic metastatic lymphadenopathy. Results A total 445 patients were 203...
Abstract Purpose To compare plan quality among photon volumetric modulated arc therapy (VMAT) and intensity‐modulated proton (IMPT) with robustness using three different beam delivery systems various spot size (σ) ranges: cyclotron‐generated beams (CPBs) (σ: 2.7–7.0 mm), linear accelerator (LPBs) 2.9–5.5 mini (LPMBs) 0.8–3.9 mm) for the treatment of head neck (HN) cancer bilateral irradiation. Methods Ten patients treated oropharynx irradiation were planned CPBs, LPBs, LPMBs, VMAT. The...
Importance A subset of Union for International Cancer Control ( UICC )/ American Joint Committee on AJCC ) eighth edition TNM stage I and II human papillomavirus–positive oropharyngeal carcinoma has undesirable outcomes, which might have contributed to a lack success in phase III deintensification trials. Refining clinical groups, especially the overabundant cN1/stage group, become important treatment selection. Objective To assess prognostic importance pretreatment lymph node (LN)...