A5006553142- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Amino Acid Enzymes and Metabolism
- Ion Channels and Receptors
- Tendon Structure and Treatment
- Immune Cell Function and Interaction
- Nerve injury and regeneration
- Microencapsulation and Drying Processes
- Cancer-related Molecular Pathways
- Postharvest Quality and Shelf Life Management
- Immune cells in cancer
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- MicroRNA in disease regulation
Emory University
2023-2025
Huzhou University
2024
Shanghai First People's Hospital
2022
Abstract N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that regulates in various important biological processes. However, its role human cancer, especially lymph node metastasis, remains largely unknown. Here, we demonstrated N-Acetyltransferase 10 (NAT10), as the only known “writer” of ac4C mRNA modification, was highly expressed head and neck squamous cell carcinoma (HNSCC) patients with metastasis. High NAT10 levels nodes HNSCC are predictor poor overall survival....
Abstract Head and neck squamous cell carcinoma (HNSCC) is addicted to glutaminolysis. Targeting this metabolic dependency has emerged as a potential therapeutic approach for HNSCC. In study, we conducted bioinformatic analysis of The Cancer Genome Atlas HNSCC cohort that revealed robust correlation between expression MYC (encoding the protein c-Myc) glutaminase 1 (GLS1), which catalyzes first step in Intriguingly, disruption GLS1 signaling cells by genetic depletion or CB-839 treatment...
Abstract The tricarboxylic acid (TCA) cycle is often rewired or dysregulated to meet the increased energy and biosynthetic demands of rapidly dividing cancer cells, targeting TCA a potential therapeutic strategy for treating cancer. However, tumor cell metabolism can impact other cells in microenvironment, disrupting could antitumor immune response. In this study, using CPI-613 as model drug inhibition, we identified molecular mechanism by which blocking enhances T-cell–mediated immunity...
Abstract FAT atypical cadherin 1 ( FAT1 ) is one of the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC), exhibiting highest mutation rate across different tumor types. Although FAT1's role has attracted considerable attention, its impact on cancer metabolism treatment resistance remains poorly understood. In this study, it demonstrated that knockout mutant HNSCC cells attenuates CPT1A‐driven fatty acid oxidation (FAO) through downregulation transcription factor...
Peripheral nerve injury (PNI) is often resulting from trauma, which leads to severe and permanently disability. Schwann cells are critical for facilitating the regeneration process after PNI. Adipose-derived mesenchymal stem (ADSCs) exosomes have been used as a novel treatment peripheral injury. However, underlying mechanism remains unclear. In this study, we isolated ADSCs extracted exosomes, were verified by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA),...
<div>Abstract<p>Head and neck squamous cell carcinoma (HNSCC) is addicted to glutaminolysis. Targeting this metabolic dependency has emerged as a potential therapeutic approach for HNSCC. In study, we conducted bioinformatic analysis of The Cancer Genome Atlas HNSCC cohort that revealed robust correlation between expression <i>MYC</i> (encoding the protein c-Myc) glutaminase 1 (GLS1), which catalyzes first step in Intriguingly, disruption GLS1 signaling cells by...
<p>Supplementary figures and tables</p>
Olmsted syndrome (OS) is a rare congenital skin disorder, typically characterized by symmetrical, severe palmoplantar and periorificial keratoderma, often accompanied alopecia, onychodystrophy, with varying degrees of pruritus pain. Gain-of-function variants the transient receptor potential cation channel subfamily V member 3 ( TRPV3 ) were described as cause OS. Here, we report an atypical case OS caused novel mutation in gene that has not been before The patient presented disabling,...