A5102981221- Network Security and Intrusion Detection
- Carcinogens and Genotoxicity Assessment
- Internet Traffic Analysis and Secure E-voting
- Natural product bioactivities and synthesis
- Network Traffic and Congestion Control
- DNA and Nucleic Acid Chemistry
- Catalytic Processes in Materials Science
- Chemical Synthesis and Reactions
- Glioma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Phytochemical Studies and Bioactivities
- Alcohol Consumption and Health Effects
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Marine Sponges and Natural Products
- Genomics, phytochemicals, and oxidative stress
- Caching and Content Delivery
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Microbial metabolism and enzyme function
- Advanced Sensor and Control Systems
- Advanced Malware Detection Techniques
- Phytochemistry and Biological Activities
- Mobile Agent-Based Network Management
- RNA modifications and cancer
Bioscience (China)
2025
Southeast University
2003-2024
University of Minnesota
2000-2024
North China University of Science and Technology
2014-2024
Luye Pharma (China)
2012-2024
Air Force Medical University
2014-2023
Xijing Hospital
2014-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
University of Minnesota Medical Center
2007-2022
Acetaldehyde is a mutagen and carcinogen which occurs widely in the human environment, sometimes considerable amounts, but little known about its reactions with DNA. In this study, we identified three new types of stable acetaldehyde DNA adducts, including an interstrand cross-link. These were formed addition to previously characterized N2-ethylidenedeoxyguanosine. was allowed react calf thymus or deoxyguanosine. The isolated hydrolyzed enzymatically; some cases, first treated NaBH3CN....
Diffusion tensor imaging (DTI) tractography reconstruction of white matter pathways can help guide brain tumor resection. However, DTI tracts are complex mathematical objects and the validity tractography-derived information in clinical settings has yet to be fully established. To address this issue, we initiated Challenge, an international working group clinicians scientists whose goal was provide standardized evaluation methods for neurosurgery. The purpose empirical study evaluate...
Background In glioblastoma (GBM), promoter methylation of the DNA repair gene O ‐methylguanine‐DNA methyltransferase (MGMT) is associated with beneficial chemotherapy. Purpose/Hypothesis To analyze radiomics features for utilizing full potential medical imaging as biomarkers MGMT methylation. Study Type Retrospective. Population/Subjects all, 98 GBM patients known (48 methylated and 50 unmethylated tumors). Field Strength/Sequence 3.0T magnetic resonance (MR) images, containing T 1 ‐weighted...
The peritoneum, especially the omentum, is a common site for gastric cancer (GC) metastasis. Our aim was to expound role and mechanisms of Piezo1 on GC omentum A series functional assays were performed examine cell proliferation, clone formation, apoptosis, Ca2+ influx, mitochondrial membrane potential (MMP) migration after overexpression or knockdown Piezo1. peritoneal implantation metastasis model conducted. After infection by si-Piezo1, number growth tumours observed in abdominal cavity....
We investigated the reactions of formaldehyde plus acetaldehyde with dGuo and DNA in order to determine whether certain 1,N2-propano-dGuo adducts could be formed. These adducts3-(2‘-deoxyribosyl)-5,6,7,8-tetrahydro-8-hydroxypyrimido[1,2-a]purine-(3H)-one (1) 3-(2‘-deoxyribosyl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-a]purine-(3H)-one (3a,b)have been previously characterized as products reaction acrolein DNA. Adduct 1 predominates model lipid peroxidation systems [Pan, J., Chung, F. L....
The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1-butanediazohydroxide (7), which is known pyridyloxobutylate DNA. A substantial proportion of the adducts in this DNA releases 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB, 11) under various hydrolysis conditions, including neutral thermal hydrolysis. These HPB-releasing have been detected target tissues animals treated with NNK...
The commercial drug paclitaxel (Taxol) may introduce hypersensitivity reactions associated with the polyethoxylated castor oil-ethanol solvent. To overcome these problems, we developed a oil-free, liposome-based alternative formulation, known as Lipusu. In this study, performed in vitro and vivo experiments to compare safety profiles of Lipusu Taxol, special regard reactions. First, Swiss mice were used determine lethal dosages, then evaluate reactions, followed by histopathological...
Abnormal metabolism serves a critical role in the development and progression of different types malignancies including glioblastoma (GBM), may therefore serve as promising target for treatment cancer. Preclinical studies have indicated that ketogenic diet (KD) exhibit beneficial effects patients with GBM; however, underlying mechanisms remain incompletely understood. The aim present study was to evaluate KD on glioma stem‑like cells (GSCs), by culturing patient‑derived primary GSCs well GSC...
DNA adducts are central in the mechanism of carcinogenesis by genotoxic agents. We compared levels a adduct acrolein, carcinogen found e-cigarette vapor, oral cell users and non-users any tobacco or nicotine product. e-Cigarette visited our clinic once monthly for 6 months, brushings urine samples were collected. For this study, we analyzed from three visits as confirmed urinary cyanoethyl mercapturic acid total equivalents. was isolated validated liquid chromatography-nanoelectrospray...
Abstract Background PIEZO1 works differently in different cancers and at stages of development. The objective the current study was to explore function underlying mechanism lung adenocarcinoma (LUAD) cells. Methods Different LUAD cell lines were treated with inhibitor (GsMTx4) agonist (Yoda1), expression cells detected using real‐time quantitative PCR (RT‐qPCR) western blotting. effects on invasion, migration epithelial‐mesenchymal transition (EMT) markers protein MTT assay, flow cytometry,...
Formaldehyde is considered carcinogenic to humans by the IARC, but there are no previous reports of formaldehyde-DNA adducts in humans. In this study, we used liquid chromatography-electrospray ionization-tandem mass spectrometry quantify adduct N(6)-hydroxymethyldeoxyadenosine (N(6)-HOMe-dAdo) leukocyte DNA samples from 32 smokers >or=10 cigarettes per day and 30 nonsmokers. Clear peaks coeluting with internal standard two different systems were seen rarely N(6)-HOMe-dAdo was detected 29...
Expression of Bcl-2 and Akt-1 has been associated with human cancer. G3139 RX-0201, targeting Akt-1, respectively, are antisense oligonucleotides (ASOs) that have shown limited efficacy in clinical trials. Herein, we report a combination newly designed ASOs based on these agents was delivered by tumor cell-targeting lipid nanoparticles (LNPs). A "Gapmer" design strategy applied to the addition 2'-O-methyl modifications nucleotides at 5' 3' ends. dual-channel syringe pump-based system...
Metabolic hydroxylation of the methyl group tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) results in formation intermediates that can alkylate DNA. Similarly, metabolic 2'-position N'-nitrosonornicotine gives DNA alkylating intermediates. The resulting pyridyloxobutyl pyridylhydroxybutyl adducts with dGuo have been characterized, but there are no reports pyrimidine adducts. Therefore,...
ABSTRACT The protein carbonic anhydrase IX (CAIX) is highly expressed in clear cell renal carcinoma (ccRCC), and its restrictive expression healthy tissues makes CAIX an attractive diagnostic target. purpose of this study was to synthesize evaluate [ 18 F]AlF‐NY104, a small‐molecule CAIX‐targeting PET agent preclinical ccRCC model. radiolabeling parameters for F]AlF‐NY104 have been optimized, including the solvent volume reaction temperature. high‐purity product synthesized by using...
Four new asterosaponins, novaeguinosides A (1), B (2), C (3), and D (4), were isolated from the bioactive fraction of starfish Culcita novaeguineae, as active compounds capable promoting polymerization tubulin. Their structures elucidated by extensive spectroscopic studies chemical evidence. Compounds 1 3 are characterized sulfated side chains not previously found in is first example a trisulfated asterosaponin. In 2 4, 26-carboxylic acid function an amide derivative taurine, which rare...
Parthenolide, the principal component of sesquiterpene lactones present in medical plants such as feverfew (Tanacetum parthenium), has been reported to have anti-tumor activity. In this study, we evaluated therapeutic potential parthenolide against bladder cancer and its mechanism action. Treatment cells with resulted a significant decrease cell viability. Parthenolide induced apoptosis through modulation Bcl-2 family proteins poly (ADP-ribose) polymerase degradation. led G1 phase cycle...
Hepatocellular carcinoma (HCC) is among the deadliest cancers globally. Yes-Associated Protein (YAP), a Hippo pathway effector, crucially regulates cell proliferation and apoptosis. Recent research has implicated YAP's role in HCC progression, but mechanisms are unclear. This study aims to clarify function HCC, emphasizing its regulation of key pathways targets. Gene knockout overexpression models were established nude mice lines cells investigate impact on tumorigenesis. Additionally,...
Reaction of formaldehyde with DNA in vitro produces a variety adducts among which are observed the cross-link di-(N6-deoxyadenosyl)methane (dAdo-CH2-dAdo, 1) and hydroxymethyl adduct N6-hydroxymethyl-dAdo (N6-HOCH2-dAdo, 2). While structures these have been known for decades, there no reports their formation vivo. Formaldehyde is released during intracellular metabolism carcinogenic N-nitrosomethyl compounds such as N-nitrosodimethylamine (NDMA) 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone...