A5071653924- Glioma Diagnosis and Treatment
- Economic Theory and Institutions
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Pain Mechanisms and Treatments
- Meningioma and schwannoma management
- Experimental Behavioral Economics Studies
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
- Radiomics and Machine Learning in Medical Imaging
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer and Skin Lesions
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Spinal Dysraphism and Malformations
- Urologic and reproductive health conditions
- Immune Cell Function and Interaction
- Head and Neck Surgical Oncology
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2013-2025
New Generation University College
2023
Kent State University
2022
Asan Medical Center
2020
Ajou University
2009-2019
Myongji University
2017
Pusan National University
2017
Woosong University
2013-2016
Catholic University of Korea
2010-2013
Next-generation sequencing (NGS) cancer profiling has gained traction in routine clinical practice South Korea. Here, we evaluated the use of NGS testing and genomically-matched therapies for patients with advanced solid tumors a real-world practice. We analyzed results from panel tests (SNUBH pan-cancer version 2) ordered June 2019 to 2020. Genomically-matched treatment was determined based on novel information obtained testing, while conventional molecular were excluded. A total 990...
Purpose Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed effect platinum-based chemotherapy on tumor PD-L1 expression and its clinical implications. Materials Methods used immunohistochemistry to retrospectively evaluate percentage cells with membranous staining (tumor proportion score) in paired specimens obtained before after neoadjuvant (NACT) 86 patients NSCLC. analyzed correlation...
The aim of this study was to determine the incidence and clinicopathological significance c-MYC gene copy-number (GCN) gain in patients with primary colorectal cancer (CRC).The GCN investigated 367 consecutive CRC (cohort 1) by using dual-color silver situ hybridization. Additionally, evaluate regional heterogeneity, we examined tissue from 3 sites including cancer, distant metastasis, lymph-node metastasis 152 advanced 2). KRAS exons 2 were for mutations.In cohort 1, amplification, defined...
The purpose of our research was to determine the prognostic impact and clinicopathological feature c-MYC β-catenin overexpression in colorectal cancer (CRC) patients. Using immunohistochemistry (IHC), we measured expression 367 consecutive CRC patients retrospectively (cohort 1). Also, by mRNA situ hybridization. Moreover, analyze regional heterogeneity, three sites including primary, distant lymph node metastasis were evaluated 176 advanced 2). In cohort 1, protein ß-catenin nuclear found...
Background Thyroid cancer is one of the most commonly detected cancers worldwide, and papillary thyroidal carcinoma (PTC) accounts for majority thyroid cancers. In contrast to indolent nature PTC, anaplastic (ATC) shows an extremely poor prognosis has not responded any therapeutic modalities. Many researchers postulate that dedifferentiation follicular cells into primitive might be related pathogenesis ATC because several cases have revealed pre-existing PTC lesions. Additionally, stem cell...
Programmed cell death ligand‐1 ( PD ‐L1) detection assays have not been standardized for patients with colorectal cancer, and the prognostic value of ‐L1 expression is unclear. We compared patterns in cancer samples using various immunohistochemical 3 primary antibodies (assay 1, MIH 1; assay 2, E1L3; 3, 22C3) investigated implication each. Additionally, gene amplification was evaluated FISH. The percentage scorings positivity rates differed; degrees correlation concordance between 2 were...
Microsatellite instability (MSI) refers to alterations in the length of simple repetitive genomic sequences. MSI status serves as a prognostic and predictive factor colorectal cancer. The MSI-high is good stage II/III cancer, predicts lack benefit adjuvant fluorouracil chemotherapy II cancer but response immunotherapy IV Therefore, determining patients with important for identifying appropriate treatment protocol. In Pathology Artificial Intelligence Platform (PAIP) 2020 challenge,...
Aims Immune checkpoint inhibitors targeting programmed death‐ligand 1 (PD‐L1) have shown promising clinical outcomes in urothelial carcinoma (UC). The combined positive score (CPS) quantifies PD‐L1 22C3 expression UC, but it can vary between pathologists due to the consideration of both immune and tumour cell positivity. Methods Results An artificial intelligence (AI)‐powered CPS analyser was developed using 1,275,907 cells 6175.42 mm 2 tissue annotated by pathologists, extracted from 400...
Radiation-induced cavernous malformations (RICMs) are rare but significant late complications of high-dose radiation therapy, particularly in young survivors brain tumors. This report presents two cases RICMs following aggressive multimodal treatment, including surgery, chemotherapy, and therapy. Case 1 was a 22-year-old male patient with medulloblastoma treated craniospinal irradiation, tumor bed boost, tandem autologous peripheral blood stem cell transplantation. Approximately 8 years...
Meningioma is a common intracranial tumor arising from the meningothelial (arachnoid) cells.Meningiomas are divided into 15 histologic subtypes and three grades, including benign (grade I), atypical II), anaplastic III). 1 Most meningiomas benign, corresponding to World Health Organization (WHO) grade I, they have favorable outcome.Alternatively, II III less outcomes. 2,3Even in cases, high recurrence rates after curative surgical treatment.They been estimated recur 7%-25%, 29%-52%, 50%-94%...
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) agonist, resiniferatoxin (RTX) would alleviate behavioral signs arthritic pain in a rat model osteoarthritis (OA). We also sought determine the effect RTX treatment on calcitonin gene-related peptide (CGRP) expression spinal cord. Knee joint inflammation induced by monosodium iodoacetate (MIA, 8 mg/50 µl) and weight bearing percentage right left hindpaws during...
Abstract Background Trichilemmal carcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC gain insight into its molecular pathogenesis. Methods Data from patients diagnosed with within a 12-year period were retrospectively reviewed. Genomic DNA isolated formalin-fixed paraffin-embedded (FFPE) tumor tissue block was sequenced and explored for panel of cancer genes. Results extracted FFPE four (50% female; mean age, 51.5 years)...
Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim this study was to investigate prognostic significance and functional implication NK cell-associated surface receptors in gastric cancer (GC) by using multiplex immunohistochemistry (mIHC).
Abstract This paper elucidates experimental economists' recent attempts to link their laboratory endeavours the realm of policies. To be concrete, by concentrating on some well-known policy-related works conducted three thriving research programs in economics, this demonstrates what kinds perspectives contemporary economists take towards a foundational issue rationality. The disunity finds practices is interpreted as source strength, rather than weakness, for economics whole. Keywords:...
Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary S-GBLs). The aim of this study was to compare the immunohistochemical classification glioblastomas with clinically determined P-GBLs and S-GBLs identify best combination antibodies for classification.We evaluated expression epidermal growth factor receptor (EGFR), p53, isocitrate dehydrogenase 1 (IDH-1) in 150 glioblastoma cases.According clinical history,...
Background: The aim of this study was to determine the regional heterogeneity and clinicopathological significance microRNA-21 (miR-21) in advanced colorectal cancer (CRC) patients with distant metastasis.Methods: miR-21 expression investigated by using locked nucleic acidfluorescence situ hybridization center periphery primary metastasis from 170 CRC.In addition, α-smooth muscle actin desmin were evaluated identify cancer-associated fibroblasts (CAFs) immunohistochemistry. Results: signal...
Abstract Background Low-grade myofibroblastic sarcoma (LGMS) is a poorly studied, rare, soft tissue sarcoma. LGMS characterized by low malignancy potential, tendency for local recurrence, and likelihood of distant metastases. However, no studies have reported on the surgical treatment method its long-term outcomes. Methods We included all patients treated at our institution between March 2010 2021. Medical charts were retrospectively reviewed to collect demographic information, as well...