A5053275797- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- CNS Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Nonmelanoma Skin Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Microbial Metabolic Engineering and Bioproduction
- Infectious Diseases and Mycology
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Liver physiology and pathology
- Mycobacterium research and diagnosis
- Thyroid and Parathyroid Surgery
Hallym University Sacred Heart Hospital
2016-2024
Seoul National University
2010-2022
Hallym University
2018-2021
University Gastroenterology
2019
Seoul National University Bundang Hospital
2011-2017
Seoul National University Hospital
2012-2016
Konkuk University Medical Center
2015
New Generation University College
2012-2014
Inflammatory pseudotumor ( IPT )‐like follicular dendritic cell FDC ) sarcoma is a rare neoplasm typically occurring in the spleen or liver. We present six cases of EBV + ‐like among K oreans along with their clinicopathologic features and IHC results. Most patients presented an asymptomatic, incidentally detected single splenic mass were successfully managed by splenectomy alone. Concomitant disease was found one case, showing gastric carcinoma lymphoid‐rich stroma. Histologic showed...
Regulation of tumor microenvironment is closely involved in the prognosis Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) an enzyme acting as immune modulator through suppression T-cell immunity. This study aims to investigate role IDO HL.A total 121 cases HL were enrolled do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers positive cells using automated image analyzer. Correlations between expression various...
We aimed to investigate MYC expression and chromosomal aberration in mantle cell lymphoma (MCL), the clinical significance of these factors.Sixty-five patients with MCL, including 54 classic, nine blastoid two pleomorphic variants, were enrolled. Expression MYC, Ki67 p53 was assessed by immunohistochemistry. amplification or translocation examined fluorescence in-situ hybridization. higher blastoid/pleomorphic MCL variants (mean, 19.0%) than classic 1.9%; P < 0.001). also significantly...
Background Thyroid cancer is one of the most commonly detected cancers worldwide, and papillary thyroidal carcinoma (PTC) accounts for majority thyroid cancers. In contrast to indolent nature PTC, anaplastic (ATC) shows an extremely poor prognosis has not responded any therapeutic modalities. Many researchers postulate that dedifferentiation follicular cells into primitive might be related pathogenesis ATC because several cases have revealed pre-existing PTC lesions. Additionally, stem cell...
Epstein–Barr virus-positive T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) include several overlapping EBV-related conditions with variably aggressive courses. For prognostic categorization, we retrospectively analyzed 42 EBV-T/NK-LPD cases. Male (79% [33/42]), young (≤40 years; 83% [35/42]) patients and T-cell lineage (81% [34/42]; CD8/CD4 = 1.8) were predominant. Clinicopathologically, three systemic one cutaneous category developed: hemophagocytic lymphohistiocytosis (HLH; 26%...
Rectal neuroendocrine tumors (NETs) are the most common gastrointestinal (GI) NETs with an uncertain malignant potential despite their small size. There limited data about driver mutations in rectal NETs, which may explain tumors' unexpected behavior or histologic morphology other GI-NETs. Here, we investigated clinically and pathologically relevant of nonrectal compared frequency clinical significance detected between them. We sequenced 84 primary GI-NETs (69 rectal, 7 gastric, 5...
BACKGROUND The cellular prion protein (PrPC), traditionally associated with neurodegenerative disorders, plays an important role in cancer progression and metastasis by inhibiting apoptosis. AIM To investigate the influence of PrPC expression cholangiocarcinoma (CCA) on patient outcomes following surgical resection. METHODS Patients who underwent curative resection for either intrahepatic or hilar CCA were enrolled this retrospective study. Based immunohistochemical staining results...
Programmed cell death-1 ligand-1 (PD-L1), essential for immune evasion, is a potential candidate pathogenesis and therapeutic target of human papillomavirus (HPV)–positive tonsillar squamous carcinomas (TSCCs). MET/hepatocyte growth factor signaling transcription factors involved in epithelial-to-mesenchymal transition (EMT) upregulate PD-L1, which can contribute to clinical outcome. Intratumoral heterogeneity PD-L1 expression importance selection bias due false-negative patient enrollment....
Despite recent progress in comprehensive genetic analysis, little is known about the molecular pathogenesis of sebaceous carcinoma. On basis ontogenic proximity and mammary glands, we designed an intrinsic classification for carcinoma adapted from that breast cancer evaluated its clinical significance. We investigated 42 cases carcinoma, including 32 ocular 10 extraocular cases. Immunohistochemical analyses estrogen receptor (ER), progesterone (PR), androgen (AR), HER2, Ki67, CK5/6...
Activation of the c-Met pathway is involved in cancer progression and prognosis. We aimed to identify any association protein expression with a number clinicopathologic variables including infection human papillomavirus Epstein-Barr virus (EBV) head neck carcinomas (HNCa).Eighty-two cases were enrolled this study. Expression p16 was investigated immunohistochemically. EBV detected by situ hybridization amplification gene fluorescence hybridization.The expressed 41.5% (34/82), found 1.4%...
Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as upregulator PD-L1 overexpression through oncogenic pathway. However, association between expression with has not been in gastric cancer.The prognostic significance of its Epstein-Barr virus (EBV), microsatellite instability (MSI), mucin phenotype remain controversial. We performed situ hybridization EBV-encoded RNA...
Aberrant expression of CD5 has been reported in 5-10% diffuse large B-cell lymphomas (DLBCLs). CD5+ DLBCL had recognized as an aggressive immunophenotypic subgroup the 2008 WHO classification haematolymphoid neoplasm; however, it was eliminated from list subgroups DLBCLs revised 2016 classification. Nevertheless, there is much controversy regarding clinical significance expression, and many researchers still assert that this exhibits extremely unfavorable prognosis with frequent treatment...
Mucosal CD30-positive T-cell lymphoproliferative disorder (CD30+ LPD) is a novel entity with unique clinicopathological features and an indolent behavior. Here we report the first case of mucosal CD30+ LPD arising in oral cavity following dental implant. A 70-year-old woman presented swelling redness mucosa right maxilla left mandible surrounding implants that had been placed 8 years previously. Radiological examination revealed enhancing lesions multiple cervical lymph nodes. Microscopic...
The prognostic value of cyclooxygenase-2 (COX-2) in human renal cell carcinoma (RCC) remains unclear. purposes this study are to elucidate the clinical significance COX-2 clear RCC (CCRCC) and assess treatment effect inhibition on CCRCC lines.Using tumor samples obtained from 137 patients who had undergone nephrectomy at Seoul National University Hospital, we evaluated expression immunohistochemistry. Moreover, performed proliferation assay using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H...
Cholangiocarcinoma arising in the liver can be classified into intrahepatic (or peripheral) cholangiocarcinoma (ICC) or perihilar cholangiocarcinoma, depending on topographic location of tumor along biliary tree.1 Grossly, peripheral ICC usually presents as a mass-forming type, while may present mass-forming, periductal infiltrating, intraductal-growth types. Histologically, is heterogeneous: majority predominantly mucin-producing adenocarcinoma, some tumors take form cholangiolocellular...
ALK-positive (ALK+) lung adenocarcinoma usually shows a more advanced-staged disease with frequent nodal metastasis and highly aggressive outcomes compared EGFR-mutated cancers. The aim of this study was to investigate the expression profiles several mucins in ALK + cancers gain insight into relationship between biological nature role mucins. We examined immunohistochemical MUC1, MUC2, MUC5AC, MUC6 19 42 were found occur younger patients characterized by solid-predominant histologic subtype...