A5010018391- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Thyroid Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Metal complexes synthesis and properties
- Thyroid and Parathyroid Surgery
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Cleft Lip and Palate Research
- Oral and Maxillofacial Pathology
- Head and Neck Anomalies
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Reconstructive Facial Surgery Techniques
Queen's Medical Center
2021-2023
University of Hawaii System
2017-2021
Weatherford College
2021
University of California, Davis
2021
Hallym University
2011-2020
Hallym University Kangnam Sacred Heart Hospital
2017-2020
Kangdong Sacred Heart Hospital
2008-2018
Hallym University Medical Center
2008-2018
Jewish General Hospital
2014-2017
McGill University
2014-2017
The purpose of this study was to assess the prevalence incidental thyroid nodules (ITN) found on computed tomography (CT) neck and determine whether CT characteristics could distinguish malignant from benign lesions.We retrospectively reviewed scans in 734 patients without known disease (384 men 350 women; mean age, 49.8 +/- 13.7 years). findings ITN such as size, shape (anteroposterior-transverse diameter ratio [AP/T ratio]), margin, peripheral enhancing rim, intralesional calcification,...
Head and neck squamous cell carcinomas (HNSCCs) display cellular heterogeneity contain cancer stem cells (CSCs). Sex-determining region Y [SRY]-box (SOX)2 is an important regulator of embryonic fate aberrantly expressed in several types human tumours. Nonetheless, the role SOX2 HNSCC remains unclear. We created ectopically expressing from previously established examined proliferation, self-renewal capacity, chemoresistance these compared with control cells. In addition, we knocked down...
Abstract Accumulating evidence suggests that a distinct subpopulation of cancer stem cells ( CSCs ) is responsible for tumour initiation and progression in head neck squamous cell carcinoma HNSCC ). Wnt/β‐catenin signalling essential regulation tumourigenesis, but its molecular mechanism remains unknown. We investigated whether regulates self‐renewal tumourigenicity stem‐like vitro vivo . Cytoplasmic/nuclear β‐catenin, major effector signalling, was expressed primary tissue none normal...
Abstract Objective: We examined the incidence of nodal involvement and attempted to determine predictive factors for central compartment lymph node (LN) metastasis in thyroid papillary microcarcinoma (PMC). Study Design: Retrospective chart review. Methods: undertook a retrospective study 52 patients treated between January 2000 December 2005 PMC by total thyroidectomy elective LN dissection with or without comprehensive lateral neck (n = 9). There were 45 women 7 men whose mean age was 47.6...
Background: In augmentation rhinoplasty, delayed morphologic changes are often observed with silicone implants, despite them being known as a safe implant material. The purpose of this study was to identify the cause and time course shape through long-term evaluation inserted implants their surrounding nasal soft tissues after removal at revision rhinoplasty operations. Methods: Two hundred twenty-one removed during were studied. period insertion ranged from 1 month 25 years, an average 6...
Background/Aims: Surgical site infection (SSI) is a major complication after radical neck dissection (RND) in patients with head and cancer (HNC). We investigated the incidence, risk factors, etiology of SSI among who underwent RND. Methods: A retrospective cohort study was performed on HNC patients, excluding those thyroid cancer, first RND at teaching hospital between January 2006 June 2010. Medical records were collected analyzed to evaluate factors microbiological etiologies. Results:...
ABSTRACT Background The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry anaplastic thyroid carcinoma (ATC) evaluated the prognostic factors treatment outcomes ATC. Methods present study enrolled 329 patients who were diagnosed with ATC between January 2000 December 2012 at 19 medical centers in Korea. Survival according to various clinical treatments. Results Multivariate analysis identified age ≥70 years old, presence initial symptoms, distant...
580 Background: Immunotherapy is the backbone of hepatocellular cancer (HCC) systemic treatments. Preclinical studies have shown that combination anti-TIM-3 antibody and anti-PD-1 more effective than either therapy alone. Early clinical experience shows cobolimab (anti-TIM-3) dostarlimab (anti-PD-1) can be safely administered. Herein we report an interim update to this phase II, single arm study in patients with untreated advanced HCC. We hypothesize immune checkpoint inhibitor will increase...
This study was conducted to identify anatomical variations of the spinal accessory nerve (SAN) in upper neck, landmark anterior and inferior border level IIb, evaluate nerve's effect on number lymph nodes (LNs) IIb.Case series with planned data collection.A total 181 neck dissections (NDs) were prospectively enrolled this study. The relation between SAN adjacent structures (internal jugular vein [IJV], sternocleidomastoid muscle [SCM], cervical plexus) LNs IIb investigated.The crossed IJV...
Abstract Background The purpose of this study was to determine the incidence, risk factors, and prognostic significance level VI lymph node metastases from hypopharyngeal squamous cell carcinoma (SCC). Methods A retrospective review 68 previously untreated patients with SCC who underwent dissection performed. Results Level occurred in 27.9% patients. occult metastasis rate 14.3%. Patients had significantly lower disease‐specific (55.1% vs 26.3%) overall survival rates (73.5% 31.6%)....
The diagnostic accuracies of the imaging studies should be clearly acknowledged in managing head and neck cancer patients; however, preoperative detecting retropharyngeal lymph node (RPLN) metastasis are still not clarified. This study was to evaluate computed tomography (CT), magnetic resonance (MRI), positron emission tomography-computed (PET-CT) RPLN squamous cell carcinomas.For 123 patients who had performed dissection during surgery their carcinoma neck, CT, MRI, and/or PET-CT were...
This study investigated whether preoperative (18)fluorine-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scanning improved the diagnosis of retropharyngeal lymph node (RPLN) metastasis in patients with head and neck squamous cell carcinoma (HNSCC) relative to conventional imaging alone.Case series chart review.University hospital cancer center.Sixty-three HNSCC underwent RPLN dissection accordance our indications were subsequently divided into two groups:...
Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, head neck squamous carcinoma (HNSCC). Previously, ligands were also reported to be associated with an enhancement stemness glioma stem-like cells. However, their role HNSCC cancer stem cells (CSCs) has not been explored. The present study demonstrated that TGFβ1...
Necrotizing Sialometaplasia (NS) is a benign, self-limiting inflammatory disease of the mucus-secreting glands, and this illness mainly involves minor salivary glands. The significance NS resides in its clinical histopathological resemblance to malignancy. We present here case necrotizing sialometaplasia on soft palate, was accompanied by adenoid cystic carcinoma. report draw attention difficulty for deciding extent resecting malignancy, especially when malignancy simultaneously sialometaplasia.
The aim of this study was to analyze the prevalence and distribution histologic cervical lymph node metastases in medial wall pyriform sinus squamous cell carcinoma (SCC).Retrospective medical records.We reviewed records 68 SCC patients who underwent bilateral neck dissection for primary treatment with curative intent. Thirty-nine central compartment dissection. Primary tumor removed using conservative laryngeal surgery partial pharyngectomy 39 cases, near total/total laryngectomy 24 total...