A5051961211- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Intraperitoneal and Appendiceal Malignancies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Surgical Treatments
- Ovarian cancer diagnosis and treatment
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Multiple and Secondary Primary Cancers
- Breast Cancer Treatment Studies
- Digestive system and related health
University of Siena
2016-2025
Azienda Ospedaliera Universitaria Senese
2013-2025
Agostino Gemelli University Polyclinic
2022-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2023
Tumori Foundation
2020
University of Turin
2016-2018
University of Verona
2011-2018
Candiolo Cancer Institute
2018
Nicolaus Copernicus University
2017
Collegium Medicum in Bydgoszcz
2017
<h3>Importance</h3> E-cadherin (<i>CDH1</i>) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse gastric (HDGC). Reliable estimates of risk and spectrum germline mutation carriers are essential for management. For without<i>CDH1</i>mutations, genetic-based stratification has not been possible, resulting limited clinical options. <h3>Objectives</h3> To derive accurate breast risks in<i>CDH1</i>mutation determine if mutations other genes associated...
Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementation genotyping validation algorithm that enables robust setting.We developed implemented an optimized platform ("OncoMap") to interrogate approximately 400 33 known oncogenes suppressors, many which are response or resistance targeted therapies....
In Brief Purpose: To investigate whether the ratio between metastatic and examined lymph nodes (N ratio) is a better prognostic factor as compared with traditional staging systems in patients gastric cancer regardless of extension node dissection. Patients & Methods: We retrospectively reviewed data 1853 who underwent radical resection for carcinoma at 6 Italian centers. >15 (group 1, n = 1421) those ≤15 2, 432) were separately analyzed. N categories 0, 0%; 1%–9%; 10%–25%; 3, >25%)...
Abstract A more detailed understanding of the somatic genetic events that drive gastrointestinal adenocarcinomas is necessary to improve diagnosis and therapy. Using data from high-density genomic profiling arrays, we conducted an analysis copy-number aberrations in 486 including 296 esophageal gastric cancers. Focal amplifications were substantially prevalent gastric/esophageal than colorectal tumors. We identified 64 regions significant recurrent amplification deletion, some shared others...
Super-extended (D2plus) lymphadenectomy after chemotherapy has been reported in only a few studies. This retrospective study evaluates survival outcomes Western cohort of locally advanced or oligometastatic gastric cancer patients who underwent D2plus neoadjuvant chemotherapy. A total 97 treated between 2010 and 2022 were included. Of these, 62 had clinical stage II/III disease, 35 IV disease. Most (65%) received preoperative DOC/FLOT The mean number lymph nodes harvested was 39....
The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).
Background: Anal HPV infection can cause squamous intraepithelial lesions (SILs), which are precursors of anal cell carcinoma (SCC). The early detection infections and improvement effective screening programmes are, therefore, essential to prevent progression from pre-cancerous SCC, especially in people living with HIV (PLWH), who represent a population at higher risk associated lesions. Among prevention strategies, vaccination is relevant too, but its efficacy persons already infected by...
Abstract Background Peritoneal carcinomatosis is a common cause of failure after surgery for gastric cancer. The present longitudinal study was designed to evaluate the incidence and potential predictors peritoneal recurrence curative resection Methods Four hundred forty-one patients who underwent potentially resections cancer in three surgical centres between 1988 1996 were evaluated. All followed using standard protocol following discharge from hospital. correlation tumour...
In Brief Objective: The aim of this prospective multicenter study was to define a scoring system for the prediction tumor recurrence after potentially curative surgery gastric cancer. Summary Background Data: estimation risk in individual patient may be relevant clinical practice, apply adjuvant therapies surgery, and plan an adequate follow-up program. Only few studies, most which were retrospective or performed on limited number patients, have developed prognostic score patients with...
Purpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains primary option in GC treatment. aim this study was to investigate impact somatic CDH1 alterations survival patients with GC. Patients Methods A series sporadic familial (diffuse intestinal; n = 246) were analyzed for mutations, promoter hypermethylation, loss heterozygosity (LOH) by polymerase chain reaction sequencing. E-cadherin protein expression determined...
Abstract Background and Objectives This study was aimed at evaluating the prognostic significance of number metastatic nodes in early gastric cancer (EGC). Methods In this multicenter retrospective 652 cases resected EGC were analyzed. We searched for lymph node metastases‐associated risk factors to identify subsets patients with different prognosis according involved nodes. Results Nodal involvement observed 14.1%. A significant correlation found between presence metastases tumor size (RR...
To conduct a retrospective evaluation of the 7th-TNM classification gastric cancer (GC) on prospectively collected database.The recent TNM introduced relevant changes to GC classification.Data regarding 2090 consecutive patients with noncardia operated upon between 1991 and 2005 at 5 specialized centers were considered. The application new was simulated, its prognostic value estimated.Relevant in stage distribution 6th 7th observed, mainly shift large proportion cases from stages IB IIA IIIA...
The presence of lymph node metastasis is one the most important prognostic factors in patients with gastric carcinoma. Node-negative have a better outcome, nevertheless subgroup them experience disease recurrence.To analyze clinicopathological characteristics node-negative advanced carcinoma submitted to gastrectomy and D2 lymphadenectomy retrieved number nodes greater than 15, after an actual follow-up almost 5 years, evaluate outcome indicators.The records 301 who underwent curative for...