A5101653004- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- S100 Proteins and Annexins
- Hospital Admissions and Outcomes
- Emergency and Acute Care Studies
- HER2/EGFR in Cancer Research
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Patient Satisfaction in Healthcare
- Genomic variations and chromosomal abnormalities
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Genomics and Chromatin Dynamics
- Central Venous Catheters and Hemodialysis
- Patient-Provider Communication in Healthcare
- Healthcare Education and Workforce Issues
- Skin Protection and Aging
- GDF15 and Related Biomarkers
- COVID-19 and Mental Health
- Digital Marketing and Social Media
- Immune Cell Function and Interaction
Seoul National University Bundang Hospital
2015-2024
Seoul National University
2018-2024
Seoul National University Hospital
2023
New Generation University College
2020
Advanced Institute of Convergence Technology
2020
Dong-A University
2013
To determine the need for care robots among nurses and to suggest how robotic should be prioritized in integrated nursing services.
// Jae Moon Gwak 1, 2 , Milim Kim 3 Hyun Jeong Min Hye Jang 4 So Yeon Park 1 Department of Pathology, Seoul National University College Medicine, Seoul, Republic Korea Green Cross Laboratory, Yongin, Bundang Hospital, Seongnam, Yeungnam Medical Center, Daegu, Correspondence to: Park, email: sypmd@snu.ac.kr Keywords: Oct4, breast cancer, cancer stem cell, prognosis, tamoxifen resistance Received: September 20, 2016 Accepted: March 21, 2017 Published: 31, ABSTRACT The transcription factors...
Various substances, including collagen (Naticol®) and ascorbic acid, that inhibit prevent skin aging have been studied. Collagen prevents aging, has anti-inflammatory effects, assists in normal wound healing. Ascorbic acid is a representative antioxidant plays role synthesis. To achieve synergistic effect of on all types, we prepared product named "TEENIALL." In addition, used container to separate the oxidation acid. confirm effects TEENIALL, first confirmed its penetrability fibroblasts,...
Although microinvasive carcinoma is distinct from ductal in situ (DCIS), the clinical significance of microinvasion DCIS remains elusive. The purpose this study to evaluate clinicopathological features and outcomes compared with pure DCIS. We assessed 613 cases that were consecutively resected 2003 2014 analyzed variables, expression standard biomarkers such as estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), p53, Ki-67, tumor recurrence. Among cases, 136...
Abstract Background The immune microenvironment in ductal carcinoma situ (DCIS) and its significance are not well established. This study was conducted to evaluate the of DCIS including composition tumor-infiltrating lymphocyte (TIL) subsets PD-L1+ cells compare it with that invasive breast cancer. Materials methods A total 671 cases three different disease groups pure DCIS, microinvasion (DCIS-M), were included this study. CD4+, CD8+, FOXP3+ TIL detected immunohistochemistry using tissue...
The microRNA-221/222 (miR-221/222) gene cluster has been reported to be associated with the promotion of epithelial-mesenchymal transition (EMT), downregulation estrogen receptor-α, and tamoxifen resistance in breast cancer. We studied expression miR-222 human cancer samples analyze its relationship clinicopathologic features tumor, including receptor status, EMT markers, clinical outcomes. Quantitative real-time polymerase chain reaction was performed detect 197 invasive cancers. Expression...
The Coronavirus disease pandemic is a global health crisis with psychological consequences for healthcare workers.To identify the prevalence and potential factors influencing burnout among frontline nurses in South Korea.This cross-sectional study comprised 161 who voluntarily participated survey through advertisements at general hospital. Data on sociodemographic professional characteristics, insomnia, depression, anxiety, stress, were collected via an online questionnaire 2021.Among...
Chromosomal instability (CIN) is known to be associated with prognosis and treatment response in breast cancer. This study was conducted determine whether copy number gain of centromere 17 (CEP17) reflects CIN, evaluate the prognostic predictive value CIN status determined by summing gains four centromeric probes (CEP1, CEP8, CEP11, CEP16) based on fluorescence situ hybridization scores were calculated using next generation sequencing data. High adverse clinicopatholgical parameters Among...
Alteration of biomarker status after primary systemic therapy (PST) is occasionally found in breast cancer. This study was conducted to clarify the clinical implications change cancer patients treated with PST.The pre-chemotherapeutic biopsy and post-chemotherapeutic resection specimens 442 who had residual disease PST were included this study. The association between changes clinicopathologic features tumors, survival patients, analyzed.Estrogen receptor (ER), progesterone (PR), human...
Intratumoral genetic heterogeneity leads to tumor progression and therapeutic resistance. However, due the difficulty associated with its assessment, use of this as a prognostic or predictive marker remains limited. To investigate significance Shannon diversity index gene copy number variation tool for measuring in breast cancer, we performed fluorescence situ hybridization c-MYC two sets invasive cancer samples correlated clinicopathologic features patient survival. The was average higher...
Abstract Cancer‐associated fibroblasts (CAFs) in the tumor microenvironment have been associated with progression breast cancer. Although crosstalk between cancer cells and CAFs has studied, effect of on non‐neoplastic epithelial is not fully understood to date. Here, we investigated aggressive phenotypes MCF10A cells. induced epithelial‐to‐mesenchymal transition (EMT) invasive phenotype S100A8, a potential prognostic marker several cancers, was markedly increased by CAFs. S100A8 crucial for...
Thyroid core needle biopsy (CNB) is increasingly being used as a tool for evaluating thyroid nodules; thus, standardization of its diagnostic terminology called for. We aimed to analyse the pathologic reporting system CNB based on recently proposed protocol by Korean Endocrine Pathology Core Needle Biopsy Study Group and evaluate usefulness.A total 1998 consecutive cases CNBs were reviewed divided into six categories according protocol. Malignancy rate in each category performance calculated...
Purpose The purpose of this study was to review the influence robot systems on nursing and robotics technology. Methods research design a article. literature done help understand current status effects robotic technology in healthcare field, both domestic overseas. keywords searched were 'Nursing', 'Robot', 'Patient safety' Pubmed, CINAHL etc, 'Nursing Activity', Care Integration Service' RISS KISS. Results In healthcare, is used five areas; personal care robots, mobility transfer cognitive...
Objective To assess a newly introduced, hospitalist-run, acute medical unit (AMU) care model at tertiary hospital in the Republic of Korea. Design Retrospective cohort study. Setting Tertiary Participants We evaluated 6391 inpatients admitted through emergency department (ED) from 1 June 2016 to 31 May 2017. Interventions The study compared multiple outcomes among ED between non-hospitalist group and AMU hospitalist group. Outcome measures In-hospital mortality (IHM), intensive (ICU)...
Multiplicity in breast cancer is common. Studies on multiple cancers have revealed high concordance biomarker status among individual lesions. However, genomic differences lesions are not well-established. We aimed to investigate the potential heterogeneity of cancer.
Abstract Chemotherapy can alter the makeup of a tumor cell population by exerting selection pressure. We examined change in Shannon index, mathematical diversity measure used ecology, for c-MYC copy number variation (CNV) after neoadjuvant chemotherapy and evaluated its clinical significance breast cancer. Associations between indices CNV pre- post-neoadjuvant cancer samples clinicopathologic features tumors as well patient survival were analyzed 144 patients. A amplification gain status was...
Hye Kyung Jin, Sung Yun Suh, Hwan Kim, A Jeong Hyun Nigh Choi, Hayeon Lee, Jiseung Hong, Oksang Hyeri Oh, Ah Young Jeon, Gahyun Jihyeon Do, Yumi Lee and Yoon Sook Cho. J. Kor. Soc. Health-syst. Pharm. 2023;40:387-408. https://doi.org/10.32429/jkshp.2023.40.4.001