A5100443839- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Cell Adhesion Molecules Research
- Pediatric Urology and Nephrology Studies
- Bacterial Infections and Vaccines
- Chronic Kidney Disease and Diabetes
- Tissue Engineering and Regenerative Medicine
- Ion Transport and Channel Regulation
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Complement system in diseases
- Renal and related cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urinary Tract Infections Management
- Electrolyte and hormonal disorders
- Central Venous Catheters and Hemodialysis
- Pancreatic function and diabetes
- Renal cell carcinoma treatment
- Acute Kidney Injury Research
- Neonatal Health and Biochemistry
- Ion channel regulation and function
- Pluripotent Stem Cells Research
- Renal and Vascular Pathologies
- Platelet Disorders and Treatments
- Vasculitis and related conditions
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2011-2025
Korea University of Science and Technology
2025
Korea Research Institute of Bioscience and Biotechnology
2025
New Generation University College
2016-2023
Chungnam National University Hospital
2019-2023
Seoul National University Children's Hospital
2017-2023
Weatherford College
2023
Pusan National University Yangsan Hospital
2019
Asan Medical Center
2019
Abstract Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with proteins, to the surroundings. Outer vesicles have gained wide interests as non-living complex vaccines or delivery vehicles. However, no study has used in treating cancer thus far. Here we investigate potential of bacterial therapeutic agents treat via immunotherapy. Our results show remarkable capability effectively induce long-term antitumor immune responses that...
Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models have been proposed as complementary approaches non-clinical animal research. However, most of these struggle accurately replicate adult human heart conditions, such infarction ventricular remodeling pathology. The intricate interplay between various cell types within the heart, including cardiomyocytes, fibroblasts, endothelial cells, contributes...
Abstract PAX2 -related disorders encompass renal coloboma syndrome (RCS) and hereditary focal segmental glomerulosclerosis (FSGS) type 7. We retrospectively analyzed 27 Korean patients with pathogenic variants detected between 2004 2022 conducted a literature review of 328 cases, including 301 previously reported. In our cohort, 19 had RCS, 4 FSGS, isolated congenital anomalies the kidneys urinary tract. Patients were classified by variant into predicted loss function (pLoF) non-pLoF groups,...
Outer membrane vesicles (OMVs) are spherical, proteolipid nanostructures that constitutively released by Gram-negative bacteria including Escherichia coli. While it has been shown administration of E. coli OMVs stimulates a strong pulmonary inflammatory response with infiltration neutrophils into the lungs in vivo, mechanism OMV-mediated neutrophil recruitment is poorly characterized. In this study, we observed significant mouse lung tissues increased expression chemoattractant CXCL1, murine...
Various substances, including collagen (Naticol®) and ascorbic acid, that inhibit prevent skin aging have been studied. Collagen prevents aging, has anti-inflammatory effects, assists in normal wound healing. Ascorbic acid is a representative antioxidant plays role synthesis. To achieve synergistic effect of on all types, we prepared product named "TEENIALL." In addition, used container to separate the oxidation acid. confirm effects TEENIALL, first confirmed its penetrability fibroblasts,...
Korean Renal Data System (KORDS) is a nationwide end-stage renal disease (ESRD) registry database operated by the Society of Nephrology (KSN). Diabetes mellitus currently leading cause ESRD in Korea; this article provides an update on trends and characteristics diabetic patients. The KORDS Committee KSN collects data dialysis centers patients through online program. Here, we analyzed status chronic kidney stage 5D (CKD 5D) using from 2001 to 2021. In 2021, adequacy hemodialysis (HD) was...
Escherichia coli, as one of the gut microbiota, can evoke severe inflammatory diseases including peritonitis and sepsis. Gram-negative bacteria E. coli constitutively release nano-sized outer membrane vesicles (OMVs). Although OMVs induce responses without live bacteria, effect in vivo on endothelial cell function has not been previously elucidated. In this study, we show that bacteria-free increased expression intercellular adhesion molecule-1 (ICAM-1), E-selectin vascular molecule-1,...
In this study, we found that expression and secretion of galectin‐3 (GAL‐3) were upregulated by amyloid‐β42 (Aβ42) exposure in human umbilical cord blood‐derived mesenchymal stem cell (hUCB‐MSC) without death. Aβ42‐exposed rat primary cortical neuronal cells co‐treated with recombinant GAL‐3 protected from death a dose‐dependent manner. hUCB‐MSCs cocultured or the neuroblastoma line, SH‐SY5Y Transwell chamber. Coculture reduced neurons cells. This neuroprotective effect was significantly...
Objectives: Technetium pertechnetate (99mTcO4) is a radioactive tracer used to assess thyroid function by uptake system (TUS). However, the TUS often fails deliver accurate measurements of percent (%thyroid uptake) 99mTcO4. Here, we investigated usefulness quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) after injection 99mTcO4 in detecting abnormalities. Materials and methods: We retrospectively reviewed data from 50 patients (male:female = 15:35; age,...
The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a regulator required for activating the innate immune response. We identified specific CNBP-binding motifs present promoter region sustained cytokines, thus, directly inducing expression target genes. In particular, lipopolysaccharide (LPS) induced cnbp through NF-κB-dependent manner and positive autoregulatory mechanism, which...
With an increasing aging population, the mean age of patients with end-stage kidney disease (ESKD) is globally increasing. However, current clinical status elderly undergoing hemodialysis (HD) rarely reported in Korea. The study analyzed features and trends older HD from Korean Renal Data System (KORDS) database. were divided into three groups according to age: <65 years (the young group), n = 50,591 (35.9%); 65-74 younger-old 37,525 (26.6%); ≥75 older-old 52,856 (37.5%). proportion group...
Synovium-derived stem cell (SDSC) is one of valuable sources for cartilage regeneration. Basic fibroblast growth factor (bFGF) was reported to augment the differentiation potential mesenchymal cells originating from a variety sources. In this study, we applied various concentrations bFGF monolayer cultures SDSCs and evaluated its effects on proliferation chondrogenesis. expressed mRNAs FGF receptor 1, 2, 3, 4, but produced only 3 protein. The were expanded as supplemented with (0, 0.1, 10,...
Background Acute kidney injury (AKI) is a critical clinical condition that requires immediate intervention. We developed an artificial intelligence (AI) model called PRIME Solution to predict AKI and evaluated its ability enhance clinicians' predictions. Methods The was using convolutional neural networks with residual blocks on 183,221 inpatient admissions from tertiary hospital (2013−2017) externally validated 4,501 at another (2020−2021). To assess application, we conducted prospective...
The impact of age on the relationship between body mass index (BMI) and all-cause mortality in hemodialysis (HD) patients is not clearly understood. We analyzed association BMI mortality, stratified by age, undergoing HD using data from Korean Renal Data System (KORDS). 66,129 2023 KORDS database, with collected 2001 2022. Patients were grouped age: <65 years ("young" group, n = 24,589), 65-74 ("younger-old" 17,732), ≥75 ("older-old" 23,808). further into quartiles. Kaplan-Meier curves event...
Background/Aim: Bacterial and viral gastroenteritis present with overlapping symptoms, including vomiting, diarrhea, abdominal pain. Stool tests have been used to differentiate between them; however, stool cultures are time-consuming polymerase chain reaction (PCR) expensive. The role of the clinical value procalcitonin (PCT) as a diagnostic marker bacterial remains be investigated. This study evaluated PCT for early diagnosis gastroenteritis. Methods: medical records patients diagnosed by...
Introduction Chimeric antigen receptor (CAR) immunotherapy has revolutionized anticancer therapy, as it accurately targets cancer cells by recognizing specific antigens expressed in cells. This innovative therapeutic strategy attracted considerable attention. However, few therapeutics are available for treating non-small cell lung (NSCLC), which accounts most cases and is one of the deadliest cancers with low survival rates. Methods In this study, we developed a new antibody targeting...
HNF1B mutations, one of the most common causes congenital anomalies kidney and urinary tract, manifest as various renal extrarenal phenotypes. We analyzed genotype-phenotype correlations in 14 pediatric patients with mutations. Genetic studies revealed total gene deletion six (43%). All had bilateral abnormalities, primarily multiple cysts. Twelve exhibited progressive functional deterioration, them progressed to failure. The annual reduction estimated glomerular filtration rate was−2.1...