A5036834575- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Neurological and metabolic disorders
- Renal and Vascular Pathologies
- Drug-Induced Hepatotoxicity and Protection
- Parathyroid Disorders and Treatments
- Electrolyte and hormonal disorders
- Poisoning and overdose treatments
- Genetic Syndromes and Imprinting
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Central Venous Catheters and Hemodialysis
- Drug-Induced Adverse Reactions
- Renal and related cancers
- Complement system in diseases
- Diet and metabolism studies
- Nephrotoxicity and Medicinal Plants
- Gout, Hyperuricemia, Uric Acid
- Pathogenesis and Treatment of Hiccups
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Kidney Injury Research
- Infective Endocarditis Diagnosis and Management
- Ion channel regulation and function
Wonkwang University
2014-2025
Albert Einstein College of Medicine
2010
Yeshiva University
2010
Chonnam National University
2009
Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) considered final common pathway to end-stage renal (ESRD). Here, we used pharmacologic, genetic, vivo, and vitro experiments show that activation Notch tubular epithelial cells (TECs) patients mouse models TIF plays role development. Expression TECs was found be both necessary sufficient for Genetic deletion reduced fibrosis. Consistent with this, TEC-specific expression active Notch1...
With an increasing aging population, the mean age of patients with end-stage kidney disease (ESKD) is globally increasing. However, current clinical status elderly undergoing hemodialysis (HD) rarely reported in Korea. The study analyzed features and trends older HD from Korean Renal Data System (KORDS) database. were divided into three groups according to age: <65 years (the young group), n = 50,591 (35.9%); 65-74 younger-old 37,525 (26.6%); ≥75 older-old 52,856 (37.5%). proportion group...
Background/Aims Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, used to attenuate peripheral vascular diseases. To determine whether PTX can improve renal hypoxia, we investigated its effect streptozocin (STZ)-induced kidney. Methods (40 mg/kg, PO) was administered STZ-induced rats for 8 weeks. tissue examined hypoxic inducible factor-1α (HIF-1α), heme oxygenase-1 (HO-1), endothelial growth factor (VEGF),...
The impact of age on the relationship between body mass index (BMI) and all-cause mortality in hemodialysis (HD) patients is not clearly understood. We analyzed association BMI mortality, stratified by age, undergoing HD using data from Korean Renal Data System (KORDS). 66,129 2023 KORDS database, with collected 2001 2022. Patients were grouped age: <65 years ("young" group, n = 24,589), 65-74 ("younger-old" 17,732), ≥75 ("older-old" 23,808). further into quartiles. Kaplan-Meier curves event...
Diabetic kidney disease (DKD) is one of the most devastating complications diabetes. Renal dysfunction develops in about one-third patients with diabetes (1). nephropathy characterized by albuminuria, glomerulosclerosis, and progressive loss renal function. Current therapies for DKD, including blood glucose control, angiotensin II receptors blockers, ACE inhibitors, slow down, but do not halt, progression to end-stage after overt has been established (2). Recent studies indicate that...
Acute kidney injury (AKI) is a risk factor for progression to chronic disease, with even subclinical AKI episodes progressing disease. Several factors such as preexisting hyperglycemia, and hypertension may aggravate renal disease after AKI. However, mechanisms underlying the of are still unclear. This study identified effect human cluster differentiation 36 (CD36) overexpression on folic acid-induced AKI.Pax8-rtTA/tetracycline response element-human CD36 transgenic mice were used elucidate...
Most rheumatic diseases are chronic inflammatory diseases. Kidney-related symptoms of often present, which increase mortality and morbidity patients with When show signs or renal involvement, management for primary should be more aggressive. In general, the risk severity involvement in depend on type Rheumatic disease itself, use immunosuppressive agents nonsteroidal anti-inflammatory drugs, comorbidities, such as diabetes, hypertension, cardiovascular complications, main causes Many studies...
Background Larger middle molecules are important substances associated with cardiovascular complications in end- stage renal disease. Unfortunately, larger not reliably removed by a high -flux dialyzer. A medium cut-off (MCO) membrane could effectively remove molecules. This study aimed to identify the long-term effect of MCO for changes Methods Thirty-four patients were prospectively analyzed 12 months. The enrolled divided into control and groups. We measured plasma levels growth...
A 36-year-old female on peritoneal dialysis (PD) who was admitted in April 2015 presented with painful erythema at the PD catheter exit site.Despite one month of antibiotic therapy, and discharge persisted.Laboratory tests showed leukocytosis.However, Gram stains cultures fluid (PF) exudates were negative.The patient underwent catheter-reposition surgery, previous site drained.However, continued peritonitis newly developed.The antibiotics switched surgery performed again.Gram-stain PF...
Diabetic kidney disease (DKD) is the most common cause of CKD. A spot urine albumin-creatinine ratio (UACR) and serum creatinine are used as an indicator DKD progression. These indicators may not reflect renal damage early DKD. The N-acetyl-β-D-glucosaminidase (NAG) found in lysosomes proximal tubular cells urinary NAG can even subclinical damage. Expression sodium-glucose cotransporter 2 (SGLT2) prominently increased diabetes. This increase excretion NAG, involved carbohydrate metabolism.
IgAN is the most common cause of primary glomerulonephritis. Generally, 30% patients progress slowly to ESKD. Disease progression and prognosis are mainly associated with clinical factors such as proteinuria, serum creatinine pathological features including glomerular sclerosis, interstitial fibrosis tubular atrophy. Many clinicians should make effort minimize through identifying risk IgAN. Therefore, it important for nephrologists take a approach correlation analysis various factors, or
A 30-year-old man receiving hemodialysis showed persistently high levels of serum intact parathyroid hormone (iPTH) and phosphate despite use intravenous calcitriol.A scan revealed increased uptake in both upper glands (Fig. 1A).However, the lesions were thought to be hyperplasia, not adenoma.This is because lesions, which uptake, did appear nodular on ultrasonography.Cinacalcet calcitriol used simultaneously treat tertiary hyperparathyroidism.After 8 months, a follow-up was performed,...
Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany use this drug, valacyclovir increasingly to treat herpes zoster, as it more effective when orally administered. This paper reports one case neurotoxicity patients with end stage renal disease who were undergoing maintenance hemodialysis. can induce life-threatening neurotoxicity, especially despite appropriate dose reduction. Furthermore,...
Primary dissection of the renal artery is rare.Spontaneous can be associated with diseases such as medial degeneration, neurofibromatosis, syphilitic arteritis, tuberculosis, polyarteritis nodosa, Marfan syndrome, fibromuscular dysplasia, or Ehlers-Danlos syndrome (EDS).Among these causes, EDS related very rare worldwide and has not been previously reported in Korea.EDS are a group heritable connective tissue disorders characterized by fragility skin hypermobility joints.We describe case...
Abstract Background and Aims Uremic toxins with middle molecular weight usually develop uremic symptoms. The larger molecules are regarded as causative of Medium cut-off (MCO) membrane newly developed can remove which be not removed through high flux hemodiafiltration. Larger mainly related to cardiovascular complications. Therefore, long-term use MCO may have beneficial effects in dialytic patients, terms lowering concentrations associated Now, we report interesting 2-year results patients....