A5100609343- Carbon Dioxide Capture Technologies
- Fusion materials and technologies
- Nuclear reactor physics and engineering
- Bacterial Infections and Vaccines
- Membrane Separation and Gas Transport
- Phase Equilibria and Thermodynamics
- Nuclear Materials and Properties
- Face and Expression Recognition
- Stochastic processes and financial applications
- Zeolite Catalysis and Synthesis
- Process Optimization and Integration
- Gaussian Processes and Bayesian Inference
- Hydrogen Storage and Materials
- Adsorption and biosorption for pollutant removal
- Advanced Clustering Algorithms Research
- Extracellular vesicles in disease
- Financial Risk and Volatility Modeling
- Surface Modification and Superhydrophobicity
- Minerals Flotation and Separation Techniques
- Magnetic confinement fusion research
- Graphite, nuclear technology, radiation studies
- Engineering Applied Research
- Climate Change Policy and Economics
- Neural Networks and Applications
- Fluid Dynamics and Mixing
Myongji University
2023-2024
Pohang University of Science and Technology
2011-2024
Korea Institute of Fusion Energy
2019-2024
Ajou University
2024
Gangnam Severance Hospital
2023
Yonsei University
2007-2023
Sungkyunkwan University
2023
Iowa State University
2022
Kyonggi University
2020
Chosun University
2007-2020
Abstract Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with proteins, to the surroundings. Outer vesicles have gained wide interests as non-living complex vaccines or delivery vehicles. However, no study has used in treating cancer thus far. Here we investigate potential of bacterial therapeutic agents treat via immunotherapy. Our results show remarkable capability effectively induce long-term antitumor immune responses that...
Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. their proteins have not been comprehensively analyzed so far. In this study, we identified 338 vesicular with high confidence by five separate LC-MS/MS analyses. This global proteome profile provides a basis future studies to elucidate pathological functions...
The support vector clustering (SVC) algorithm is a recently emerged unsupervised learning method inspired by machines. One key step involved in the SVC cluster assignment of each data point. A new labeling for developed based on some invariant topological properties trained kernel radius function. Benchmark results show that proposed outperforms previously reported techniques.
Gram-positive bacteria naturally produce extracellular vesicles. However, little is known regarding the functions of bacterial vesicles, especially in community. Here, we investigated role Staphylococcus aureus vesicles interbacterial communication to cope with antibiotic stress. We found that S. liberated BlaZ, a β-lactamase protein, via These enabled other ampicillin-susceptible Gram-negative and survive presence ampicillin. did not mediate survival tetracycline-, chloramphenicol-, or...
Pseudomonas aeruginosa is often involved in lung diseases such as cystic fibrosis. These bacteria can release outer membrane vesicles (OMVs), which are bilayered proteolipids with diameters of approximately 20 to 250 nm. In vitro, these OMVs activate macrophages and airway epithelial cells. The aim this study was determine whether from P. induce pulmonary inflammation vivo elucidate the mechanisms involved. Bacteria-free were isolated cultures. Wild-type, Toll-like receptor (TLR)2 TLR4...
Outer membrane vesicles (OMVs) are spherical, proteolipid nanostructures that constitutively released by Gram-negative bacteria including Escherichia coli. While it has been shown administration of E. coli OMVs stimulates a strong pulmonary inflammatory response with infiltration neutrophils into the lungs in vivo, mechanism OMV-mediated neutrophil recruitment is poorly characterized. In this study, we observed significant mouse lung tissues increased expression chemoattractant CXCL1, murine...
Sepsis is one of the major causes death in hospital patients and represented by systemic inflammatory response syndrome (SIRS) associated with infection. Gram-negative bacteria including Escherichia coli can provoke sepsis stimulating immune systems. Outer membrane vesicles (OMVs), nanosized vesicular structures derived from bacteria, contain several pathogen-associated molecular patterns, are demonstrated to mediate SIRS. Here, extracellular vesicle-mimetic ghost nanovesicles loaded...
Escherichia coli, as one of the gut microbiota, can evoke severe inflammatory diseases including peritonitis and sepsis. Gram-negative bacteria E. coli constitutively release nano-sized outer membrane vesicles (OMVs). Although OMVs induce responses without live bacteria, effect in vivo on endothelial cell function has not been previously elucidated. In this study, we show that bacteria-free increased expression intercellular adhesion molecule-1 (ICAM-1), E-selectin vascular molecule-1,...
ABSTRACT This article proposes the variables repetitive group sampling plan where quality characteristic follows normal distribution or lognormal and has upper lower specification limit. The problem is formulated as a nonlinear programming objective function to be minimized average sample number constraints are related lot acceptance probabilities at acceptable level (AQL) limiting (LQL) under operating curve. Sampling tables constructed for selection of parameters indexed by AQL LQL in...
Clustering methods utilizing support estimates of a data distribution have recently attracted much attention because their ability to generate cluster boundaries arbitrary shape and deal with outliers efficiently. In this paper, we propose novel dissimilarity measure based on dynamical system associated estimating functions. Theoretical foundations the proposed are developed applied construct clustering method that can effectively partition whole space. Simulation results demonstrate is...
Pneumonia due to Gram-negative bacteria is associated with high mortality. Acinetobacter baumannii a bacterium that hospital-acquired and ventilator-associated pneumonia. Bacteria have been described release outer membrane vesicles (OMVs) are capable of mediating systemic inflammation. The mechanism by which A. OMVs mediate inflammation not fully defined. We sought investigate the roles Toll-like receptors (TLRs) play in OMV-mediated pulmonary isolated from cultures intranasally introduced...
In this letter, we develop a gaussian process model for clustering. The variances of predictive values in processes learned from training data are shown to comprise an estimate the support probability density function. constructed variance function is then applied construct set contours that enclose points, which correspond cluster boundaries. To perform clustering tasks associated dynamical system built, and its topological invariant property investigated. experimental results show proposed...