A5064504666- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Proteoglycans and glycosaminoglycans research
- Cellular Mechanics and Interactions
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Pluripotent Stem Cells Research
- Dental Implant Techniques and Outcomes
- Mesenchymal stem cell research
- Congenital heart defects research
- Mechanical Circulatory Support Devices
- Additive Manufacturing and 3D Printing Technologies
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Monoclonal and Polyclonal Antibodies Research
- Advanced Sensor and Energy Harvesting Materials
- Cardiac Arrest and Resuscitation
- Angiogenesis and VEGF in Cancer
- Optical Coherence Tomography Applications
- Cardiac Arrhythmias and Treatments
- Muscle metabolism and nutrition
- Nerve injury and regeneration
Korea University
2016-2025
Yonsei University
2024
Tsinghua University
1999-2024
Zhejiang Wanli University
2011-2024
Severance Hospital
2024
Korea University Medical Center
2007-2019
Seoul Institute
2019
Government of the Republic of Korea
2019
Samsung Medical Center
2015
Sungkyunkwan University
2015
As rubber-like elastomers have led to scientific breakthroughs in soft, stretchable characteristics-based wearable, implantable electronic devices or relevant research fields, developments of degradable with comparable mechanical properties could bring similar technological innovations transient, bioresorbable electronics expansion into unexplored areas. Here, we introduce ultra-stretchable, biodegradable capable stretching up ~1600% outstanding toughness, tear-tolerance, and storage...
In this paper, we introduce a new continuous production technique of calcium alginate fibers with microfluidic platform similar to spider in nature. We have used poly(dimethylsiloxane) (PDMS) device embedded capillary glass pipet as the apparatus for fiber generation. As sample flow, introduced sodium solution, and, sheath CaCl2 solution was introduced. The coaxial flows were generated at intersection both flows, and solidified by diffusion Ca2+ ions during traveling through outlet pipet....
In this paper, we have developed a method to produce poly(lactic-co-glycolic acid) (PLGA) microfibers within microfluidic chip for the generation of 3D tissue engineering scaffolds. The synthesis PLGA fibers was achieved by using polydimethylsiloxane (PDMS)-based spinning device in which linear streams dissolved dimethyl sulfoxide (DMSO) were precipitated glycerol-containing water solution. By changing flow rate solution from 1 50 µL/min with sheath 250 or 1000 µL/min, formed diameters that...
Alginate-only, cell-laden, and protein-immobilized hollow fibers are produced (see image). Cells remain alive within the due to nontoxic fabrication process. Vascular tissue can be emulated by embedding endothelial cells into alginate then these cell-laden smooth-muscle-cell-laden AGF hydrogels. Detailed facts of importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please...
A poly(ethylene glycol) (PEG)-based hydrogel was used as a scaffold for chondrocyte culture. Branched PEG-vinylsulfone macromers were end-linked with thiol-bearing matrix metalloproteinase (MMP)-sensitive peptides (GCRDGPQGIWGQDRCG) to form three-dimensional network in situ under physiologic conditions. Both four- and eight-armed PEG macromer building blocks examined. Increasing the number of arms increased elastic modulus hydrogels from 4.5 13.5 kPa. PEG-dithiol prepare that not sensitive...
Abstract Spinal cord injury leads to the permanent loss of motor and sensory function in body. To enhance spinal regeneration, we used a hyaluronic acid‐based hydrogel as three‐dimensional biomimetic scaffold for peptides growth factors. Three components were provide guidance cues: matrix metalloproteinase peptide crosslinker, an IKVAV (Ile‐ Lys‐Val‐Ala‐Val) derived from laminin, brain‐derived neurotrophic factor (BDNF). Human mesenchymal stem cells (hMSCs) cultured hydrogels vitro 10 days...
An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A induced in rat by circumflex artery ligation. hyaluronic acid-based injected into epicardium infarcted area. Then, cardiac functions regeneration myocardium sham-operated (SHAM), (MI), gel-injected group (GEL) (n = 6) were evaluated 4 weeks after injection. Measurements thickness wall showed that GEL increased up 200% compared with MI (p < 0.001). The area left ventricular...
Water-droplet adhesiveness was freely controlled on a single platform of superhydrophobic anodized aluminum oxide (AAO) within the range from highly adhesive to self-cleanable. Changing structure nanopore nanopillar arrays at surface caused dramatic increase in receding angle and decrease hysteresis water contact angles. The presence dead-end nanopores but not through nanoholes recognized as one main causes surfaces. adhesiveness-controllable AAO can be an excellent which elucidate physical...
Bioprinting is a technology for constructing bioartificial tissue or organs of complex three-dimensional (3-D) structure with high-precision spatial shape forming ability in larger scale than conventional engineering methods and simultaneous multiple components composition ability. It utilizes computer-controlled 3-D printer mechanism solid free-form fabrication technologies. In this study, sodium alginate hydrogel that can be utilized large-dimension its fast gelation property was studied...
Abstract Hyaluronic acid is a natural glycosaminoglycan involved in biological processes. Low‐molecular‐weight hyaluronic (10 and 50 kDa)‐based hydrogel was synthesized using derivatized acid. acrylated by two steps: (1) introduction of an amine group adipic dihydrazide, (2) acrylation N ‐acryloxysuccinimide. Injectable acid‐based prepared poly(ethylene glycol) tetra‐thiols via Michael‐type addition reaction. Mechanical properties the were evaluated varying molecular weight kDa) percent...
Abstract Hyaluronic acid (170 kDa)‐based hydrogel was synthesized using acrylated hyaluronic (HA) and matrix metalloproteinase (MMP) sensitive HA‐based hydrogels were then prepared by conjugation with two different peptides: cell adhesion peptides containing integrin‐binding domains (Arg‐Gly‐Asp: RGD) a cross‐linker MMP degradable to mimic the remodeling characteristics of natural extracellular matrices cell‐derived MMPs. Mechanical properties these evaluated weight percentages (2.5 3.5 wt...
Abstract Axis formation and related spatial patterning are initiated by symmetry breaking during development. A geometrically confined culture of human pluripotent stem cells (hPSCs) mimics cell patterning. Using this, polarized spinal cord organoids (pSCOs) with a self‐organized dorsoventral (DV) organization generated. The application caudalization signals promoted regionalized differentiation along the radial axis protrusion morphogenesis in hPSC colonies. These detached colonies grew...
The efficacy of coronavirus disease 2019 (COVID-19) vaccination is closely related to the serum levels SARS-CoV-2-neutralizing antibodies (NAb) that bind receptor-binding domain (RBD) SARS-CoV-2 spike protein. Therefore, rapid and quantitative measurement NAb in sera vaccinated individuals essential develop an effective vaccine further achieve population immunity, is, herd immunity. plaque reduction neutralization test, gold standard for effectiveness serological tests, accurate but requires...
Carbon nanotube (CNT) monolayer patterns are utilized to control the growth of mesenchymal stem cells (MSCs) (see figure). MSCs exhibit preferential on CNT patterns, suggesting that does not have a harmful effect MSCs. Furthermore, swCNT between electrodes is demonstrated. These results show enormous potential as new platform for basic research and applications using cells. Supporting information this article available WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c0875_s.pdf or...
A number of factors must be added to human bone marrow stromal cells (hBMSCs) in vitro induce osteogenesis, including ascorbic acid (AA), β ‐glycerophosphate (GP), and dexamethasone (Dex). Bone morphogenic protein (BMP)‐2 is an osteoinductive factor that can commit differentiate into osteoblasts. However, it still not clear whether the addition BMP‐2 alone hBMSCs complete osteoblast differentiation, resulting matrix mineralization. This study compares effects Dex, combined, on early late...