A5072543703- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Cardiac Fibrosis and Remodeling
- Free Radicals and Antioxidants
- Genomics, phytochemicals, and oxidative stress
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Signaling Pathways in Disease
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Hydrogels: synthesis, properties, applications
- Facial Trauma and Fracture Management
- Conducting polymers and applications
- Peptidase Inhibition and Analysis
- Biochemical effects in animals
Korea Institute of Science and Technology
2025
Korea University
2021-2023
Asan Medical Center
2018-2019
University of Ulsan
2018-2019
As rubber-like elastomers have led to scientific breakthroughs in soft, stretchable characteristics-based wearable, implantable electronic devices or relevant research fields, developments of degradable with comparable mechanical properties could bring similar technological innovations transient, bioresorbable electronics expansion into unexplored areas. Here, we introduce ultra-stretchable, biodegradable capable stretching up ~1600% outstanding toughness, tear-tolerance, and storage...
Glutamate-induced neuronal death is associated with neurodegeneration including cerebral ischemia. Several μ-opioid receptor antagonists exhibit a neuroprotective activity and have been considered as potential therapeutic option for neurodegenerative disorders. For the first time, our current study unveiled of selective δ-opioid antagonists. A potent, antagonist naltriben, also known potent TRPM7 agonist, displayed prominent protective effect against glutamate-induced toxicity through opioid...
Bone graft materials are commonly used to regenerate various bone defects, but their application is often limited because of the complex defect shape in clinical conditions. Hence, customized grafts using three-dimensional (3D) printing techniques have been developed. However, conventional simple models for evaluating benefits and manufacturing accuracy 3D-printed grafts. Thus, aim present study was develop a complex-shaped model. We designed an 8-shaped bony that consists two circles...
The onlay-graft, one of the most difficult graft conditions, is used for diverse clinical including plastic and dental surgery. should withstand continuous pressure from overlying tissues have excellent bone formation capability in a limited contact situation. We recently developed 3D printed Kagome-structured polycaprolactone (PCL) scaffold that has stronger mechanical property. This study evaluated feasibility this onlay-graft use. value containing recombinant human morphogenetic protein-2...
Stromal cell-derived factor-1 alpha (SDF-1α, CXCL12) mediates the migration of circulating cells to desired sites for tissue development, homeostasis, and regeneration can be used promote cardiac by recruiting stem cells. However, use SDF-1α in injured heart necessitates not only higher binding affinity its receptor, CXCR4+, but also better robustness against enzymatic degradation than other SDF-1 isoforms. Here, we conduct a screening analog peptides that were designed structure-based drug...
Abstract Cancer immunotherapy by immune checkpoint inhibitors (ICI) acts on antitumor responses stimulating the system to attack cancer cells. However, this powerful therapy is hampered its high treatment cost and limited efficacy. Here, we show development of an antibody-conjugating (Conjugel) that potentiates efficacy bispecific simultaneously targets CTLA-4 PD-L1. The Conjugel, consisting highly deformable nanogels antibody-binding protein, was loaded with two ICI monoclonal antibodies...
Abstract Cancer immunotherapy by immune checkpoint inhibitors (ICI) acts on antitumor responses stimulating the system to attack cancer cells. However, this powerful therapy is hampered its high treatment cost and limited efficacy. Here, we show development of an antibody-conjugating (Conjugel) that potentiates efficacy bispecific simultaneously targets CTLA-4 PD-L1. The Conjugel, consisting highly deformable nanogels antibody-binding protein, was loaded with two ICI monoclonal antibodies...