A5102000006- Metabolomics and Mass Spectrometry Studies
- Chemical Synthesis and Analysis
- Carbon Nanotubes in Composites
- Microbial Natural Products and Biosynthesis
- Fullerene Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Carbohydrate Chemistry and Synthesis
- Fungal Biology and Applications
- Advanced Synthetic Organic Chemistry
- Synthetic Organic Chemistry Methods
- Traditional Chinese Medicine Studies
- Genomics and Phylogenetic Studies
- Natural product bioactivities and synthesis
- Mass Spectrometry Techniques and Applications
- Marine Sponges and Natural Products
- Graphene research and applications
- Identification and Quantification in Food
- Phytoestrogen effects and research
- Advanced Proteomics Techniques and Applications
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Properties of Aromatic Compounds
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Magnetic Bearings and Levitation Dynamics
- Protein purification and stability
Zhejiang Sci-Tech University
2025
Xiamen University
2010-2022
South China Agricultural University
2022
Hanshan Normal University
2021
Harbin Medical University
2016
Luoyang Institute of Science and Technology
2016
Tongji University
2015
Gansu Agricultural University
2000-2011
With the development of biotechnologies and computational prediction algorithms, number experimental RNA-associated interactions has grown rapidly in recent years. However, diverse are scattered over a wide variety resources organisms, whereas fully comprehensive view is still not available for any species. Hence, we have updated RAID database to version 2.0 (RAID v2.0, www.rna-society.org/raid/) by integrating from manually reading literature other under one common framework. The new...
Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether contributes to metabolic reprogramming. Here we find can interact with and phosphorylate hexokinases HK1 HK2, the rate-limiting enzymes glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity thus enhances Mechanistically, of at Tyr732 robustly decreases its K m V max by disrupting dimer formation. Mutation site either or HK2 remarkably abrogates...
Ambiguity in malignant transformation of glioma has made prognostic diagnosis very challenging. Tumor is closely correlated with specific alterations the metabolic profile. Exploration underlying cells different degree therefore vital to develop biomarkers for prognosis monitoring. We conducted 1H nuclear magnetic resonance (NMR)-based analysis on cell lines (CHG5, SHG44, U87, U118, U251) developed from gliomas grades (WHO II and WHO IV). Several methods were applied analyze 1H-NMR spectral...
Gastric cancer (GC) is one of the most malignant tumors with a poor prognosis. Alterations in metabolic pathways are inextricably linked to GC progression. However, underlying molecular mechanisms remain elusive. We performed NMR-based metabolomic analysis sera derived from rat model gastric carcinogenesis, revealed significantly altered correlated progression carcinogenesis. Rats were histologically classified into four pathological groups (gastritis, GS; low-grade dysplasia, LGD;...
Macropanax rosthornii (Harms) C.Y.Wu ex G.Hoo 1900 is a small tree or evergreen shrub of the family Araliaceae, mainly distributed in southern China and Vietnam with distribution area. M. kind high-quality wild ornamental plant resource also known for its effective medicinal treatment fracture, rheumatoid arthritis, traumatic injury, infant malnutrition, etc. In this study, first complete chloroplast genome was reported phylogenetic analysis conducted other 10 species from Araliaceae. The...
Some studies have proved that both acupuncture and moxibustion are very effective for the treatment of CAG. However, little is known about therapeutic mechanism electro-acupuncture on CAG as well difference between them. On other hand, metabolomics a 'top-down' approach to understand metabolic changes organisms caused by disease or interventions in holistic context, which consists with thinking treatment. In this study, rats was investigated 1H NMR-based analysis multiple biological samples...
For the first time an easier, operable combustion method is employed for synthesis of non-IPR fullerene, and octahydro[60]fullerene with a C60 cage (C60 isomer #1809C60) produced by isolated characterized MS, UV−vis, IR, NMR spectroscopies in combination DFT calculations. This finding shows that, addition to chlorine, hydrogen can be ample cataloreactant production fullerene derivatives under such conditions as arc-burning diffusion combustion.
Abstract Five glutarimide alkaloids cordiarimide A ( 5 ), B 6 crotonimide 3 4 and julocrotine 2 ) have been synthesized starting from Boc‐ L ‐glutamine 7 ). The benzylic alcohol chiral centre of cordiarimides has established in 6:1 diastereoselectivity by catalytic asymmetric hydrogenation using Zhou's system Pd(CF CO /( R , )‐Me‐DuPhos.
Abstract The hydrofullerene C 50 H 10 is synthesized by low‐pressure benzene–oxygen diffusion combustion. structure of identified through NMR, mass spectrometry, and IR Raman spectroscopy as a D 5 h symmetric closed‐cage molecule with five pairs fused pentagons stabilized ten hydrogen atoms. UV/Vis fluorescence spectrometric analyses disclose its optical properties comparable those chloride cousin (C Cl ). Cyclic square‐wave voltammograms reveal that the first reduction potential more...
Abstract The first enantioselective synthesis of cytotoxic natural products rigidiusculamides A ( ent‐ 21 ) and B 8 has been achieved by two synthetic routes. one is convergent based on the common intermediate 11 , obtained through a high yielding SmI 2 ‐mediated Reformatsky‐type reaction. highly diastereoselective one‐pot Dess–Martin periodinane‐mediated bis‐oxidation allowed direct conversion diastereomeric mixture into rigidiusculamide ). Isolation minor diastereomer in combination with...
Although derivatives of fullerenes are prevalent in the fullerene-producing flame, chemistry these has rarely been discussed previous literature. In this paper, two D5h-C70 derivatives, C70(C14H10) and C70(C5H6), were isolated from soot an acetylene–benzene combustion. On basis detailed MS, NMR, IR, UV/vis analyses combination with DFT calculations, cycloadduct structures C70(C5H6) identified. Both anthracene (C14H10) cyclopentadiene (C5H6) adducts, supposed as intermediate species produced...
A synthesis program for structurally complex macrocycles is very challenging. Herein, we propose a biosynthesis pathway of the pyranylated cyclodepsipeptide verucopeptin to make enough supply and diversify by genetic manipulation one-step semisynthesis. The relies on intrinsic reactivity interchangeable hemiketal pyrane opened keto along with adjacent alkene. Biological evaluation verucopeptin-oriented analogs delivers potent AMP-activated protein kinase (AMPK) agonist, antibacterial agent,...
The synthesis of a plausible key intermediate for biomimetic asymmetric indole alkaloid arboflorine is described. method featured the use Ellman's sulfinamide chemistry establishment first chiral center, and Polonovski-Potier reaction formation α-aminonitrile moiety.
Eight new cytochalasins 1-8 and ten known analogs 9-18 were isolated from the endophytic fungus Phomopsis sp. xz-18. The planar structures of determined by HR-ESI-MS NMR analysis. Compounds 1, 2, 9 10 5/6/6/7/5-fused pentacyclic cytochalasins; compounds 3 4 had conjugated diene in macrocycle; compound 6 a β,γ-unsaturated ketone. absolute configuration was confirmed for first time octant rule. acid-free purification process proved that system natural biosynthetic product not an acid-mediated...
Ethnopharmacological relevance: Two types of traditional Chinese formulas botanical drugs are prescribed for treating perimenopausal syndrome (PMS), a disorder in middle-aged women during their transition to menopause. One is PMS as kidney deficiency (KD) due senescence and declining reproductive functions, the other it liver qi stagnation (LQS) association with stress anxiety. Despite time-tested prescriptions, an objective attestation effectiveness treatment still be established associated...
Abstract An improved three‐steps method for the conversion of N‐benzyl (S)‐3‐hydroxypyrrolidin‐2‐one 6 to (2S,3S)‐3‐hydroxyproline 1 is reported. The key step reductive cyanation 6. synthesis constitutes a formal asymmetric betaines 2. Keywords: 3‐Hydroxyproline3‐Hydroxyproline betainesReductive Acknowledgment We are grateful NNSC financial support.