A5100371868- Pancreatic function and diabetes
- Synthesis of Tetrazole Derivatives
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Nuclear Receptors and Signaling
- Mesenchymal stem cell research
- Functional Brain Connectivity Studies
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Esophageal Cancer Research and Treatment
- Chemical Synthesis and Reactions
- Neuroscience and Neural Engineering
- Gastric Cancer Management and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Pancreatitis Pathology and Treatment
- Asymmetric Hydrogenation and Catalysis
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Oxidative Organic Chemistry Reactions
- Osteoarthritis Treatment and Mechanisms
- Nerve injury and regeneration
- Photoreceptor and optogenetics research
- Phytochemical Studies and Bioactivities
Beijing Radiation Center
2023-2025
Guangzhou Center for Disease Control and Prevention
2024-2025
Shanghai Jiao Tong University
2020-2025
Shanghai University of Traditional Chinese Medicine
2024
Academy of Military Medical Sciences
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
General Hospital of Shenyang Military Region
2024
Nanjing Agricultural University
2024
Tianjin Medical University
2024
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how transmits lack occupancy by FBP remains unclear. Here, we show that FBP-unoccupied interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease at contact sites between ER lysosome renders inhibited TRPV accessible bind v-ATPase then...
Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether contributes to metabolic reprogramming. Here we find can interact with and phosphorylate hexokinases HK1 HK2, the rate-limiting enzymes glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity thus enhances Mechanistically, of at Tyr732 robustly decreases its K m V max by disrupting dimer formation. Mutation site either or HK2 remarkably abrogates...
The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy, despite considerable success anti-tumor immunotherapy. poor response cancer cells immune destruction an essential contributor failure checkpoint therapy. We hypothesized that combining therapy with natural-product chemosensitizer could enhance response. Herein, a targeted diterpenoid derivative was integrated blockade (anti-CTLA-4) improve immunotherapy using thermosensitive...
Abstract Background and aims Severe acute pancreatitis (SAP) is potentially lethal. Considering the role of inflammation in progression (AP), this study to develop a model based on inflammatory indexes for identifying presence SAP. Methods Overall, 253 patients with AP who were consecutively admitted between July 2018 November 2020 screened, whom 60 had Systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR),...
To establish an in vitro cell model simulating acute graft-versus-host disease (aGVHD) bone marrow microenvironment injury with the advantage of mouse serum aGVHD and explore effect on adipogenic differentiation ability mesenchymal stem cells (MSCs). The 6-8-week-old C57BL/6N female mice BALB/c were used as donor recipient model, respectively. Bone transplantation (BMT) (n=20) was established by being injected (1×107 per mouse) from within 4-6 hours after receiving a lethal dose (8.0 Gy,...
Stereochemistry editing serves as an important tool to precisely adjust the desired stereochemical configuration of a molecule. In this study, enabled by photocatalytic tertiary C-H bonds steroids, we have completed concise syntheses (25S)-Δ7-dafachronic acid, demissidine, and smilagenin. The feasibility regioselectively stereocenters with either very weak α-hydroxyl (in synthesis dafachronic acid), α-amino demissidine), or varying steric hindrance smilagenin) has been successfully demonstrated.
Stereochemistry editing serves as an important tool to precisely adjust the desired stereochemical configuration of a molecule. In this study, enabled by photocatalytic tertiary C‐H bonds steroids, we have completed concise syntheses (25S)‐Δ7‐dafachronic acid, demissidine, and smilagenin. The feasibility regioselectively stereocenters with either very weak α‐hydroxyl (in synthesis dafachronic acid), α‐amino demissidine), or varying steric hindrance smilagenin) has been successfully demonstrated.
Recent studies have suggested that targeting senescent cells in joint tissues may alleviate osteoarthritis (OA) progression. However, this strategy encounters significant challenges, partially due to the high degree of cellular heterogeneity osteoarthritic tissues. Moreover, little information is available on role skeletal stem cell (SSC) senescence, as compared differentiated cells, OA In study, single-cell RNA sequencing (scRNA-seq) articular cartilages and subchondral bones knee joints...
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 convert from antiapoptotic a pro-apoptotic molecule. posttranslational modification such as phosphorylation has been shown induce translocation nucleus mitochondria. However, small molecules that can bind directly trigger its mitochondrial localization and interaction remain be explored. Here, we report our identification...
Leucocytozoon parasites infect a large number of avian hosts, including domestic chicken, and cause significant economical loss to the poultry industry. Although transmission stages were observed in blood cells more than century ago, specific host cell type(s) that gametocytes remain uncertain. Because all cells, red (RBCs), are nucleated, developing dramatically change morphology infected it has been difficult identify cell(s). Here we use cell-type antibodies investigate identities by...
Abstract Patients with relapsed/refractory (R/R) mature T- and natural killer (NK)–cell neoplasms lack effective treatments after failure of standard therapies. This phase 2 study evaluated the efficacy safety programmed cell death protein 1 inhibitor tislelizumab in these patients. Seventy-seven patients were treated 200 mg every 3 weeks. Twenty-two extranodal NK-/T-cell lymphomas enrolled cohort 1; 44 peripheral T-cell lymphoma (PTCL) (21 had PTCL not otherwise specified, 11...
Abstract Background Though articular cartilage stem cell (ACSC)-based therapies have been demonstrated to be a promising option in the treatment of diseased joints, wide variety isolation, unknown therapeutic targets, and incomplete understanding interactions ACSCs with microenvironments limited applications ACSCs. Methods In this study, human isolated from osteoarthritic by advantage selection anatomical location, migratory property cells, combination traumatic injury, mechanical stimuli...
The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects traditional treatments. In this work, a transferrin receptor (TfR) targeted immunostimulant (PTI) is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting
Peripheral nerve injury gives rise to devastating conditions including neural dysfunction, unbearable pain and even paralysis. The therapeutic effect of current treatment for peripheral is unsatisfactory, resulting in slow regeneration incomplete recovery function. In this study, suture combined with ADSCs injection was adopted rat model sciatic injury. Under real-time visualization the injected cells guidance NIR-II fluorescence imaging vivo , a spatio-temporal map displaying cell migration...