A5100782757- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Sperm and Testicular Function
- Ovarian function and disorders
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Ectopic Pregnancy Diagnosis and Management
- Microtubule and mitosis dynamics
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Drug-Induced Adverse Reactions
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Plant Molecular Biology Research
- Spinal Cord Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Inflammasome and immune disorders
- Genomics and Chromatin Dynamics
- Management of metastatic bone disease
- Plant Gene Expression Analysis
- Nausea and vomiting management
Shantou University
2014-2025
First Affiliated Hospital of Shantou University Medical College
2009-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Guangdong Academy of Medical Sciences
2023-2025
Sun Yat-sen University
2019-2025
Sun Yat-sen University Cancer Center
2019-2025
Shanghai Jiao Tong University
2016-2024
Shanghai Children's Medical Center
2023-2024
Academy of Military Medical Sciences
2023-2024
Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice. Methods: performed disproportionality Bayesian analyses based on data first quarter 2004 third 2021 Food Drug Administration Adverse Event Reporting System characterize signal differences drugs-related DILI. also compared onset time mortality different agents. Results: A total 2943 DILI were identified. Affected patients...
Our study aimed to develop embryo models evaluate the impact of oxidative stress on development. Mouse zygotes, which stayed at G1 phase, were treated with prepared culture medium (containing 0.00, 0.01, 0.02, 0.03, 0.04, 0.05, or 0.1 mM hydrogen peroxide (H 2 O )) for 30 min in experiment 1. The dose‐effects H development investigated via comparisons formation rate each stage (2‐ and 4‐cell embryos blastocysts). Experiment was carried out compare behaviors a mild oxidative‐stressed status...
A simple, reliable, and accurate method was developed for quantitative assessment of metabolite coverage in preclinical safety species by mixing equal volumes human plasma with blank animal vice versa followed an analysis using high-resolution full-scan mass spectrometry. This approach provided comparable results (within (±15%) to those obtained from regulated bioanalysis did not require synthetic standards or radiolabeled compounds. In addition, both qualitative data were a single LC-MS on...
The hostile environment of an injured spinal cord makes it challenging to achieve higher viability in a grafted tissue-engineered neural network used reconstruct the circuit. Here, we investigate whether cell survival and synaptic transmission within NT-3 TRKC gene-overexpressing stem cell-derived scaffold (NN) transplanted into transected could be promoted by electroacupuncture (EA) through improving microenvironment. Our results showed that EA facilitated survival, neuronal...
Naringin exhibited various pharmacological activities. However, its biological function and underlying mechanism in regulating macrophage polarization remain elusive. This study aimed to investigate the regulatory network between naringin sepsis-induced intestinal injury. Cecal ligation puncture (CLP) was used establish animal model of sepsis. Chromatin immunoprecipitation a luciferase reporter assay were determine interplay peroxisome proliferator-activated receptor γ (PPARγ) miR-21...
Aims: To explore the population pharmacokinetics of colistin sulfate and to optimize dosing strategy for critically ill patients. Methods: The study enrolled adult patients who received intravenously more than 72 h with at least one measurement plasma concentration. Colistin concentrations in or urine samples were measured by ultraperformance liquid chromatography tandem mass spectrometry (LC-MS/MS). (PPK) model was developed using Phoenix NLME program. Monte Carlo simulation conducted...
A 2-year-old boy presented with loss of appetite and recurrent cough expectoration for 1 year. Abdominal radiography performed 3 months prior revealed a circular, bead-like high-density shadow in the upper abdomen. Eleven magnetic beads were successfully extracted via gastroscopy at local hospital; however, subsequent abdominal X-ray indicated that one bead remained fixed position ([Fig. 1]).
In zygotes, the capacity of G2/M checkpoint and DNA repair mechanisms to respond damage varies depending on different external stressors. our previous studies, we found that mild oxidative stress induced a phase delay in mouse zygotes fertilized vitro, due activation spindle assembly checkpoint. However, it is unclear whether involves G2 arrest, triggered by checkpoint, AMPK, highly conserved cellular energy sensor, involved arrest zygotes. Here, treated with 0.03 mM H2O2 at 7 h...
Abstract In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved tumor formation. However, molecular mechanisms underlying this phenomenon remain largely unclear. Using a well-established model oxidatively damaged mouse embryos, we applied iTRAQ method to identify proteins differentially expressed between control and zygotes explored possible tumorigenic mechanisms, especially with regard effects on ribosome...
Abstract Background Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available. Psoralen is principal bioactive component of Cullen corylifolium (L.) Medik has been reported to have antitumor, anti-inflammatory, pro-osteogenesis activities. However, less information available regarding role psoralen treatment injury. In this study, we explored modulatory effects on skeletal stem cells their protective injuries....
Glycogen storage disease type Ib (GSD-Ib) is a rare inborn error of glycogen metabolism caused by mutations in SLC37A4. Patients with GSD-Ib are at high risk developing inflammatory bowel (IBD). We evaluated the efficacy empagliflozin, renal sodium‒glucose cotransporter protein 2 (SGLT2) inhibitor, on colonic mucosal healing patients GSD-associated IBD. A prospective, single-arm, open-label clinical trial enrolled eight IBD from Guangdong Provincial People's Hospital China July 1, 2022...
Abstract Patients with glycogen storage disease type Ib (GSD‐Ib) frequently have inflammatory bowel (IBD). however, the underlying etiology remains unclear. Herein, this study finds that digestive symptoms are commonly observed in patients GSD‐Ib, presenting as single or multiple scattered deep round ulcers, pseudo‐polyps, obstructions, and strictures, which differ substantially from those typical IBD. Distinct microbiota profiling single‐cell clustering of colonic mucosae GSD conducted....
Abstract Transposable elements (TEs) comprise approximately half of eukaryotic genomes and significantly contribute to genome plasticity. In this study, we focused on a specific TE, MERVL, which exhibits particular expression during the 2-cell stage commonly serves as an indicator embryonic totipotency. However, its precise role in embryo development remains mysterious. We utilized DRUG-seq investigate effects oxidative damage genes TEs expression. Our findings revealed that exposure...
How to screen beneficiary populations has always been a clinical challenge in the treatment of non-small-cell lung cancer (NSCLC) with immune checkpoint inhibitors (ICIs). Routine blood tests, due their advantages being minimally invasive, convenient, and capable reflecting tumor dynamic changes, have potential value predicting efficacy ICIs treatment. However, there are few models based on routine tests predict prognosis immunotherapy. Patients were randomly divided into training cohort...
Human sperm cryopreservation for assisted reproduction is compromised by ROS-induced cryodamage. Our previous model study in which mouse were treated with H2O2 to simulate DNA-damage caused cryopreservation-induced ROS have discovered that embryos fertilized showed a delay cleavage might be associated cell cycle arrest. The checkpoint pathway underlying the remained elusive. Moreover, our also indicated γH2AX, repair marker, was functional similarly fertilized, but completeness and...
Background Cryopreservation of human semen for assisted reproduction is complicated by cryodamage to spermatozoa caused excessive reactive oxygen species (ROS) generation. Methods and Findings We used exogenous ROS (H2O2) simulate cryopreservation examined DNA damage repair in embryos fertilized with sperm H2O2-induced damage. Sperm samples were collected from epididymis adult male KM mice treated capacitation medium (containing 0, 0.1, 0.5 1 mM H2O2) or cryopreservation. The model...
Gonadotropins play vital roles in the regulation of female reproductive ability and fertility. Our study aimed to determine effects superovulation induced by increasing doses equine chorionic gonadotropin [eCG; also referred as pregnant mare serum (PMSG)] on developmental competence mouse embryos aneuploidy formation during vitro fertilization (IVF). eCG dose-dependently enhanced oocyte yield from each mouse. Administration 15 IU significantly reduced rate four-cell blastocysts increased...