A5020372758- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Effects and risks of endocrine disrupting chemicals
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Tryptophan and brain disorders
- Pesticide and Herbicide Environmental Studies
- Reproductive System and Pregnancy
- Cystic Fibrosis Research Advances
- Recycling and Waste Management Techniques
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Insect and Pesticide Research
- interferon and immune responses
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Microplastics and Plastic Pollution
- Drug Transport and Resistance Mechanisms
- Extracellular vesicles in disease
- Pregnancy and Medication Impact
- Food Security and Health in Diverse Populations
Zhejiang Shuren University
2021-2024
Zhejiang University of Technology
2016-2023
Microplastics (MPs) are considered as a pollutant of marine environments and have become global environmental problem in recent years. A number studies demonstrated that MPs can enter the human food chain, even been detected stools. Therefore, there is increasing concern about potential risks to animal health. Here, we investigated maternal polystyrene exposure during gestation lactation evaluated effects on dams F1 (both PND 42 280) F2 (PND 42) generations. The results transcriptome 16S...
Plant-derived nanovesicles (PDNVs) have been proposed as a major mechanism for the inter-kingdom interaction and communication, but effector components enclosed in vesicles mechanisms involved are largely unknown. The plant Artemisia annua is known an anti-malaria agent that also exhibits wide range of biological activities including immunoregulatory anti-tumor properties with to be further addressed. Here, we isolated purified exosome-like particles from A. annua, which were characterized...
Recent studies have provided insights into the gut microbiota in autism spectrum disorder (ASD); however, these were restricted owing to limited sampling at unitary stage of childhood. Herein, we aimed reveal developmental characteristics a large cohort subjects with ASD combined interindividual factors impacting microbiota.
Due to a long history of improper and excessive use, Penicillin G (Pen G) erythromycin (Ery) are regularly detected in environmental samples pose great threat human health. Here, we set out investigate effects Pen G, Ery or their mixture on lipid metabolism gut microbiota order better understand toxicological mechanisms. Male C57BL/6J mice were exposed either 60 μg/ml half both for 6 weeks 10 14 weeks. In recovery experiment, male 2 then maintained without antibiotics up 8 It was observed...
The fungicide imazalil (IMZ) is widely used to prevent and treat fungal diseases in plants animals. Here, male adult C57BL/6 mice were exposed 0.1, 0.5, 2.5 mg/kg body weight IMZ for 2, 5, or 15 weeks. microbiota cecal contents feces changed during chronic exposure at phylum genus levels. Sequencing of the V3-V4 region bacterial 16S rRNA gene revealed a significant change richness after Operational taxonomic unit (OTU) analysis indicated that 31.1% OTUs 14.0% fecal exposure. In addition,...
Preeclampsia (PE) is a condition of high blood pressure that usually concurrent with proteinuria in pregnancy. PE complicates the management both maternal and fetal health contributes to most adverse pregnancy outcomes, but mechanism underlying development remains unclear. In this study, we performed case-control study compare gut microbiota (n = 26), abnormal placental growth (APG, n 25) healthy pregnant women 28) analyzed potential pathogenic role progression.The clinical...
Abstract Despite accumulating evidence linking defective lysosome function with autoimmune diseases, how the catabolic machinery is regulated to maintain immune homeostasis remains unknown. Late endosomal/lysosomal adaptor, MAPK and mTOR activator 5 (Lamtor5) a subunit of Ragulator mediating mechanistic target rapamycin complex 1 (mTORC1) activation in response amino acids, but its action mode physiological role are still unclear. Here it demonstrated that Lamtor5 level markedly decreased...
Carbendazim (CBZ), a systemic, broad-spectrum benzimidazole fungicide, is widely used to control fungal diseases and has been regarded as an endocrine disruptor that causes mammalian toxicity in different target organs. Here, we discovered chronic administrations of CBZ at 0.2, 1, 5 mg/kg body weight for 14 weeks not only changed the composition gut microbiota but also induced significant increases body, liver, epididymal fat mice. At biochemical level, serum triglyceride (TG) glucose levels...
Abstract As an effective fungicide widely used in agricultural production, the excessive procymidone (PRO) residue has been detected environment and food. Our previous study demonstrated that PRO could destroy intestinal barrier mice a joint toxic effect. To explore cross‐generational impact of maternal exposure, 10‐week‐old C57BL/6 female were orally administrated to 10 100 mg/kg body weight/day during pregnancy lactation. The offspring obtained nutrients from through placenta breast milk,...
Background: Currently no specific treatments are available for sepsis and the associated syndromes including acute lung injury (ALI). Jinhong Decoction (JHD) is a traditional Chinese prescription, it has been applied clinically as an efficient safe treatment sepsis, but underlying mechanism remains unknown. The aim of study was to explore potential mechanisms JHD ameliorating concurrent ALI. Methods: cecum ligation puncture (CLP)- induced murine model established determining efficacy...