A5080551821- Immune cells in cancer
- Extracellular vesicles in disease
- interferon and immune responses
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Protein Degradation and Inhibitors
- Calcium signaling and nucleotide metabolism
- PI3K/AKT/mTOR signaling in cancer
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Fuel Cells and Related Materials
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
Nanjing University of Chinese Medicine
2021-2024
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be associated pathogenesis ALI (acute lung injury). Exosomes from adipose-derived mesenchymal stem cells (AdMSC-Exos) have been distinguished by their low immunogenicity, lack tumorigenicity, and high clinical safety, but role in treating the mechanism involved need defined. In this study, we sought investigate whether mitochondrial donation AdMSC-Exos provides profound protection against LPS-induced mice,...
Plant-derived nanovesicles (PDNVs) have been proposed as a major mechanism for the inter-kingdom interaction and communication, but effector components enclosed in vesicles mechanisms involved are largely unknown. The plant Artemisia annua is known an anti-malaria agent that also exhibits wide range of biological activities including immunoregulatory anti-tumor properties with to be further addressed. Here, we isolated purified exosome-like particles from A. annua, which were characterized...
Disproportionately high incidence and mortality of respiratory infection such as influenza A virus (IAV) SARS-CoV-2 have been evidenced in the elderly, but role mechanism age-associated immune deregulation disease exacerbation are not well defined. Using a late generation mice deficient telomerase RNA (Terc-/- ), we herein demonstrated that aged were exquisitely susceptible to viral infection, with excessive inflammation increased mortality. Furthermore, identified cGAS/STING pathway, which...
Abstract Despite accumulating evidence linking defective lysosome function with autoimmune diseases, how the catabolic machinery is regulated to maintain immune homeostasis remains unknown. Late endosomal/lysosomal adaptor, MAPK and mTOR activator 5 (Lamtor5) a subunit of Ragulator mediating mechanistic target rapamycin complex 1 (mTORC1) activation in response amino acids, but its action mode physiological role are still unclear. Here it demonstrated that Lamtor5 level markedly decreased...
Abelmoschus manihot (L.) Medicus (AM) is a medicinal plant with various biological activities, including anti-inflammatory, antioxidant, antiviral and immunomodulatory. Previous studies have identified total flavones as the primary bioactive ingredient of AM (termed TFA). However, its role mechanism in counteracting Influenza A virus (IAV) infection are yet to be explored. Therefore, study aims anti-inflammatory effects TFA on IAV vitro vivo.A network pharmacology-based approach was applied...
Dendritic cells (DCs) are recognized as a key orchestrator of immune response and homeostasis, deregulation which may lead to autoimmunity such experimental autoimmune encephalomyelitis (EAE). Herein we show that the phosphatase PP2Cδ played pivotal role in regulating DC activation function, ablation caused aberrant maturation, activation, Th1/Th17-priming DCs, hence induced onset exacerbated EAE. Mechanistically, restrained expression essential subunit mTORC2, Rictor, primarily through...
Abstract Plant-derived nanovesicles (PDNVs) have been proposed as a major mechanism for inter-kingdom interaction and communication, but the effector components enclosed mechanisms involved are largely unknown. The plant Artemisia annua , known its anti-malaria properties, exhibits wide range of biological activities including immunoregulatory anti-tumor properties with to be further addressed. Here, we isolated purified exosome-like particles from characterized them nano-scaled...
Innate immunological memory or trained immunity is increasingly recognized, but fundamental issues regarding specific signals and mechanisms driving immunity, particularly in tumor setting, remain largely unknown. Our study indicates that acute priming induced development of CD11b+F4/80+Ly6C-PD-L1+Bcl6+ macrophage subset, which was characterized by stem signature genes, long-term persistence, self-renewing, pro-tumor memory, therefore termed stem-like macrophages (SMMs). The transcription...