A5091165765- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Advanced Mathematical Modeling in Engineering
- Advanced Numerical Methods in Computational Mathematics
- Single-cell and spatial transcriptomics
- Reservoir Engineering and Simulation Methods
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Composite Material Mechanics
- Corporate Finance and Governance
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Legume Nitrogen Fixing Symbiosis
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Peanut Plant Research Studies
- Hydraulic Fracturing and Reservoir Analysis
- Cancer-related gene regulation
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- Enhanced Oil Recovery Techniques
- MicroRNA in disease regulation
- Plant Virus Research Studies
Soochow University
2021-2025
Central China Normal University
2025
ExxonMobil (Germany)
2005-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
Beijing University of Chinese Medicine
2025
Jiangsu Provincial Center for Disease Control and Prevention
2025
ExxonMobil (United States)
2007-2024
National Center for Nanoscience and Technology
2019-2024
Henan Academy of Agricultural Sciences
2022-2024
We propose a multiscale finite element method for solving second order elliptic equations with rapidly oscillating coefficients. The main purpose is to design numerical which capable of correctly capturing the large scale components solution on coarse grid without accurately resolving all small features in solution. This accomplished by incorporating local microstructures differential operator into base functions. As consequence, functions are <italic>adapted</italic> properties operator. In...
Alternative polyadenylation (APA) has been shown to play an important role in gene expression regulation animals and plants. However, the extent of sense antisense APA at genome level is not known. We developed a deep-sequencing protocol that queries junctions 3′UTR poly(A) tails confidently maps tags annotated genome. The results this mapping show 70% Arabidopsis genes use more than one site, excluding microheterogeneity. Analysis reveal extensive introns coding sequences, which can...
DNA origami has played an important role in various biomedical applications, including biosensing, bioimaging, and drug delivery. However, the function of long scaffold involved yet to be fully exploited. Herein, we report a general strategy for construction genetically encoded by employing two complementary strands functional gene as therapy. In our design, sense antisense can directly folded into monomers their corresponding staple strands. After hybridization, assembled with precisely...
The multiscale finite element method (MsFEM) [T. Y. Hou, X. H. Wu, and Z. Cai, Math. Comp., 1998, to appear; T. Hou J. Comput. Phys., 134 (1997), pp. 169--189] has been introduced capture the large scale solutions of elliptic equations with highly oscillatory coefficients. This is accomplished by constructing base functions from local operator. Our previous study reveals that leading order error in this approach caused ``resonant sampling,' which leads when mesh size close small continuous...
Flow based upscaling of absolute permeability has become an importantstep in practical simulations flow through heterogeneous formations.The central idea is to compute upscaled, grid-block from fine scalesolutions the equation. Such solutions can be either local each grid-blockor global whole domain. It well-known that grid-blockpermeability may strongly influenced by boundary conditions imposedon equations and size grid-blocks. We show upscalingerrors due both effects manifest as resonance...
The position of a poly(A) site eukaryotic mRNA is determined by sequence signals in pre-mRNA and group polyadenylation factors. To reveal rice at genome level, we constructed dataset 55 742 authenticated sites characterized the signals. This resulted identifying typical tripartite cis-elements, including FUE, NUE CE, as previously observed Arabidopsis. average size 3′-UTR was 289 nucleotides. When mapped to genome, however, 15% these were found be located currently annotated intergenic...
Reservoir modeling is playing an increasingly important role in developing and producing hydrocarbon reserves. In this paper, we provide a brief overview of some main challenges reservoir modeling, i.e., accurate efficient complex geometry heterogeneous properties. We then present techniques recently developed addressing these challenges, including method for generating constrained Voronoi grids generic global scale-up method. focus on the gridding method, which based new Delaunay...
Precisely assembled DNA nanostructures are promising candidates for the delivery of biomolecule-based therapeutics. Herein, we introduce a facile strategy construction branched DNA-based nanoplatform codelivery gene editing (sgRNA/Cas9, targeting in nucleus) and silencing (antisense, mRNA cytoplasm) components synergistic tumor therapy vitro vivo. In our design, structure can efficiently load sgRNA/Cas9/antisense complex tumor-associated gene, PLK1, through self-assembly. With incorporation...
Socio-spatial differentiation and residential segregation have been studied extensively in numerous cities contributed significantly to the understanding of urban spatial social structures. Analyses diverse data sets at varied scales supported development theoretical frameworks. However, majority Chinese case studies published recent decades were dominantly based on either non-spatial or population census sub-district (or jiedao Chinese) level. These analyses limited through using...
Alternative polyadenylation (APA) has been increasingly recognized as a crucial mechanism that contributes to transcriptome diversity and gene expression regulation. As RNA-seq become routine protocol for analysis, it is of great interest leverage such unprecedented collection data by new computational methods extract quantify APA dynamics in these transcriptomes. However, research progress this area relatively limited. Conventional rely on either transcript assembly determine 3' ends or...
Introduction Music has a profound impact on human emotions, capable of eliciting wide range emotional responses, phenomenon that been effectively harnessed in the field music therapy. Given close relationship between and language, researchers have begun to explore how influences brain activity cognitive processes by integrating artificial intelligence with advancements neuroscience. Methods In this study, total 120 subjects were recruited, all whom students aged 19 26 years. Each subject is...
The Arabidopsis thaliana ortholog of the 30-kD subunit mammalian Cleavage and Polyadenylation Specificity Factor (CPSF30) has been implicated in responses plants to oxidative stress, suggesting a role for alternative polyadenylation. To better understand this, poly(A) site choice was studied mutant (oxt6) deficient CPSF30 expression using genome-scale approach. results indicate that large majority genes is altered oxt6 mutant. A number sites were identified are seen only wild type or...
Polyadenylation sites mark the ends of mRNA transcripts. Alternative polyadenylation (APA) may alter sequence elements and/or coding capacity transcripts, a mechanism that has been demonstrated to regulate gene expression and transcriptome diversity. To study role APA in dynamics, we analyzed large-scale data set RNA “tags” signify poly(A) levels mRNA. These tags were derived from wide range tissues developmental stages mutated or exposed environmental treatments, generated using digital...
Haihui Fu1,5, Dewei Yang2,5, Wenyue Su1, Liuyin Ma1, Yingjia Shen1, Guoli Ji3, Xinfu Ye2, Xiaohui Wu3 and Qingshun Q. Li1,2,4 1Key Laboratory of the Ministry Education for Coastal Wetland Ecosystems, College Environment Ecology, Xiamen University, Xiamen, Fujian, China, 361102; 2Rice Research Institute, Fujian Academy Agricultural Sciences, Fuzhou, 350018; 3Department Automation, 361005; 4Graduate Biomedical Western University Health Pomona, California 91766, USA Corresponding authors:...
Abstract Chemically modified DNA has been widely developed to fabricate various nucleic acid nanostructures for biomedical applications. Herein, we report a facile strategy construction of branched antisense and small interfering RNA (siRNA) co‐assembled nanoplatform combined gene silencing in vitro vivo. In our design, the can efficiently capture siRNA with 3′ overhangs through DNA–RNA hybridization. After being equipped an active targeting group endosomal escape peptide by host–guest...
The plant parasitic nematode Aphelenchoides besseyi is a major pest that poses serious threats to different vegetables and crop plants. In the present study, volatiles isolated from Bacillus spp. were utilized as green biocontrol agents overcome nematodes. in vitro experiment, GBSC56, SYST2, FZB42 showed strongest nematicidal activity with killing rates of 80.78%, 75.69%, 60.45%, respectively, compared control. selected synthetic volatile organic compounds (VOCs), namely albuterol,...
Abstract Background Pod shell thickness (PST) is an important agronomic trait of peanut because it affects the ability shells to resist pest infestations and pathogen attacks, while also influencing shelling process. However, very few studies have explored genetic basis PST. Results An F 2 segregating population derived from a cross between thick-shelled cultivar Yueyou 18 (YY18) thin-shelled Weihua 8 (WH8) was used identify quantitative loci (QTLs) for On bulked segregant analysis...