A5090252237- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Ovarian function and disorders
- Tissue Engineering and Regenerative Medicine
- Reproductive System and Pregnancy
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- Microtubule and mitosis dynamics
Shantou University
2016-2023
First Affiliated Hospital of Shantou University Medical College
2016-2023
Our study aimed to develop embryo models evaluate the impact of oxidative stress on development. Mouse zygotes, which stayed at G1 phase, were treated with prepared culture medium (containing 0.00, 0.01, 0.02, 0.03, 0.04, 0.05, or 0.1 mM hydrogen peroxide (H 2 O )) for 30 min in experiment 1. The dose‐effects H development investigated via comparisons formation rate each stage (2‐ and 4‐cell embryos blastocysts). Experiment was carried out compare behaviors a mild oxidative‐stressed status...
In zygotes, DNA damage delays the first cleavage to enable repair. Our previous study found that 0.03 mM hydrogen peroxide (H2O2) was minimum concentration required for induction of oxidative in mouse zygotes and this represented most similar situation clinical phenomenon. study, we quantified rates cells blastocysts at different developmental stages, followed by immunofluorescence detect activation γ-H2A histone family member X (a marker damage) confirm induced H2O2-treated zygotes....
The process of ovarian cryopreservation and transplantation is the only feasible fertility preservation method for prepubertal girls female patients with cancer who cannot delay radiotherapy chemotherapy. However, basic research on this technique lacking. To better understand function oocyte quality after tissue (OT) transplantation, we characterised appearance, angiogenesis, endocrine grafts in a murine model; mitochondrial DNA damage oocytes isolated from OT; development embryos vitro...
As a proinflammatory cytokine, tumor necrosis factor-α (TNF-α) is central to the female reproductive tract and affects various phases of follicular development uterine cycles. High levels TNF-α play vital role in pathogenesis polycystic ovary syndrome (PCOS) patients. Clinicians know that dexamethasone can inhibit induction androgen by suppressing adrenal glands which improves status endocrine system PCOS We hypothesize has much more functionality exert therapeutic effect antagonizing TNF-α....