A5100681545- Lipid metabolism and biosynthesis
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Plant-Microbe Interactions and Immunity
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Plant Pathogens and Fungal Diseases
- RNA modifications and cancer
- Circular RNAs in diseases
- Photosynthetic Processes and Mechanisms
- Carcinogens and Genotoxicity Assessment
- Research in Cotton Cultivation
- Pharmacogenetics and Drug Metabolism
- Microtubule and mitosis dynamics
- Cellular Mechanics and Interactions
- Genetic and Kidney Cyst Diseases
- Plant Reproductive Biology
- Plant Pathogens and Resistance
- Spaceflight effects on biology
- Soybean genetics and cultivation
- Cancer-related gene regulation
- 3D Printing in Biomedical Research
- Plant Gene Expression Analysis
- Cancer, Lipids, and Metabolism
University of Arizona
2018-2025
Tianjin Medical University General Hospital
2013-2025
Northwest A&F University
2013-2024
Heilongjiang University of Chinese Medicine
2024
Jilin Agricultural University
2023
Capital Institute of Pediatrics
2023
Nanjing University of Chinese Medicine
2023
Zhejiang University
2015-2023
Chongqing University of Technology
2023
Guangdong Medical College
2022
Venezuela Orinoco heavy crude oil was sequentially separated into several subfractions to determine the contents and types of vanadyl porphyrins contained in products. Vanadium each subfraction were detected using an atomic absorption spectrometer (AAS) combined with characterization by ultraviolet–visible (UV–vis) spectroscopy positive-ion electrospray ionization (ESI) Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS). Six petroleum porphyrins, which have been...
HOX transcript antisense intergenic RNA (HOTAIR), a well‑known long non‑coding RNA, plays an important role in the regulation of epithelial‑to‑mesenchymal transition (EMT). In this study, we propose novel mechanism through which HOTAIR promotes EMT by switching histone H3 lysine 27 acetylation to methylation at E‑cadherin promoter, induces transcriptional inhibition E‑cadherin. recruits polycomb repressive complex 2 (PRC2) catalyze H3K27me3; however, whether is associated with 27, marker...
The ubiquitin-conjugating enzyme 2C (UBE2C) is the key component in ubiquitin proteasome system (UPS) by partnering with anaphase‑promoting complex (APC/C). A high UBE2C protein expression level has been reported various types of human tumors. However, little known about precise mechanism which downregulated gastric cancer. We found MGC‑803 and SGC‑7901 cancer cells UBE2C‑deficient G2/M phase arrest cell cycle subsequently decreased adenocarcinoma tumorigenesis. In previous study, we...
Angiotensin II (ANGII) and its receptor (AGTR1) have been proposed as significant contributors to metastasis in multiple cancers. Further, high AGTR1 levels are associated with poor epithelial ovarian cancer (EOC) outcomes. However, the mechanistic basis for these effects is unknown. Recent studies suggested that highly dependent on formation of multicellular spheroids (MCS). To understand associations between ANGII/AGTR1 pathway outcomes, we evaluated ANGII MCS by cells used a proteomic...
Colletotrichum fructicola, which is part of the C. gloeosporioides species complex, can cause anthracnose diseases in strawberries worldwide. However, molecular interactions between fructicola and strawberry are largely unknown. A deep RNA-sequencing approach was applied to gain insights into pathogenicity mechanisms defense response plants at different stages infection. The transcriptome data showed stage-specific transcription accompanied by a step-by-step evasion this system fungus....
The increasing demand for healthy edible oil has generated the need to identify promising crops. Tree peony (Paeonia section Moutan DC.) is a woody crop with α-linolenic acid contributing 45% of total fatty (FA) content in seeds. Molecular and genetic differences that contribute varied FA composition among wild species are however, poorly understood. Analyses during seed development three tree (P. rockii, P. potaninii, lutea) showed highest followed by lutea. Total increased reached its...
Cucumber mosaic virus (CMV) is a highly prevalent viral pathogen causing substantial damage to the bulb and cut-flower production of Lilium spp. Here, we performed an Illumina RNA sequencing (RNA-Seq) study on leaf tissues virus-resistant species regale inoculated with mock control CMV. A total 1346 differentially expressed genes (DEGs) were identified in leaves L. upon CMV inoculation, which contained 34 up-regulated 40 down-regulated DEGs that encode putative transcription factors (TFs)....
The disease symptoms recognized as 'Anthracnose' are caused by Colletotrichum spp. and lead to large-scale strawberry (Fragaria×ananassa Duchesne) losses worldwide in terms of both quality production. Little is known regarding the mechanisms underlying genetic variations strawberry-Colletotrichum interaction. In this work, gloeosporioides (C. gloeosporioides) infection was characterized two varieties exhibiting different susceptibilities, involvement salicylic acid (SA) examined. Light...
As the largest Chinese city by population and proper in world, Shanghai has frequently suffered heavy haze recent years. In this study, observational data (PM2.5, PM10, O3, NO2, CO SO2) at ten urban monitoring stations from November 25 to December 9, 2013, were used analyze pollution. The source contributions of PM2.5 identified trajectory clustering hybrid receptor models (potential contribution function (PSCF) concentration weighted (CWT)). results showed that for whole study period,...
Tree peony (Paeonia section Moutan DC.) species are woody oil crops with high unsaturated fatty acid content, including α-linolenic (ALA/18:3; >40% of the total acid). Comparative transcriptome analyses were carried out to uncover underlying mechanisms responsible for and low ALA content in developing seeds P. rockii lutea, respectively. Expression analysis acyl lipid metabolism genes revealed upregulation select involved plastidial synthesis, editing, desaturation, triacylglycerol assembly...
Objective Thyroid disease has been reported to associate with gut microbiota, but the effects of thyroid cancer and nodules on oral microbiota are still largely unknown. This study aimed identify variation in salivary their potential association nodules. Methods We used 16S rRNA high-throughput sequencing examine patients (n = 14), 9), healthy controls 15). Results The alpha-diversity indices Chao1 ACE were found be relatively higher compared controls. beta diversity both groups was...
Seed oil not only provides energy for seed postgermination development but also essential nutrients and raw materials human products. However, the transcriptional regulatory mechanism controlling accumulation remains largely unknown. Tree peony (Paeonia rockii) is an emerging woody oilseed crop in China that known its high-quality oil. Here, we revealed a tree nuclear factor Y transcription factor, PrNF-YC2, expressed predominantly developing seeds functions as positive regulator of...
Abstract α-Linolenic acid (ALA), an essential fatty (FA) for human health, serves as the precursor of 2 nutritional benefits, docosahexaenoic and eicosapentaenoic acid, can only be obtained from plant foods. We previously found that phospholipid:diacylglycerol acyltransferase (PrPDAT2) derived ALA-rich tree peony (Paeonia rockii) promote seed ALA accumulation. However, regulatory mechanism underlying its promoting effect on accumulation remains unknown. Here, we revealed a...
Proton coupled oligopeptide transporter 1 (PEPT1) is a member of the peptide superfamily and plays important role in absorption peptidomimetic drugs. Our previous research verified that PEPT1 expressed specifically human Hepatocellular carcinoma (HCC) tissue cell lines showed potential transport activity to be new candidate tumor therapeutic target. In this study, we aim explore feasibility novel target strategy: Targeting improve antitumor efficacy Doxorubicin HCC therapy. First, was...
Tree peony (Paeonia rockii) is an excellent woody oilseed crop, known for its high α-linolenic acid (ALA, ~45%) content, which of great value human health. However, the mechanisms underlying this high-level ALA accumulation in tree seeds are poorly understood. In study, we evaluated dynamic changes lipidomic profile P. rockii during development. A total 760 lipid molecules were identified seeds; triacylglycerol (TAG) showed highest abundance and diversity, both increasing seed Particularly,...
Rilpivirine (RPV) is a potent antiretroviral drug used for the long-term management of HIV infection. The high crystallinity and very low aqueous solubility RPV are responsible highly variable pharmacokinetics seen in HIV-infected patients. While fatty meals can increase absorption RPV, lipid precludes development oral lipid-based formulations such as self-nanoemulsifying systems (SNES). To improve delivery we evaluated potential six biocompatible bulky anions to transform into amphiphilic...
The extents to which small intestinal (SI) cytochrome P450 (P450) enzymes control the bioavailability of oral drugs are not well defined, particularly for that substrates both and P-glycoprotein (P-gp). In this study, we have determined role SI in clearance orally administered lovastatin (LVS), an anti-hypercholesterolemia drug, using epithelium (IE)-specific reductase knockout (IE-<i>Cpr</i>-null) mouse model. IE-<i>Cpr</i>-null mouse, has little activities IE, LVS was substantially higher...