A5004340070- Nuclear Receptors and Signaling
- Synthesis of Tetrazole Derivatives
- Retinoids in leukemia and cellular processes
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Estrogen and related hormone effects
- Synthesis and Characterization of Heterocyclic Compounds
- Genetic and Kidney Cyst Diseases
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
Xiamen University
2019-2024
Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 convert from antiapoptotic a pro-apoptotic molecule. posttranslational modification such as phosphorylation has been shown induce translocation nucleus mitochondria. However, small molecules that can bind directly trigger its mitochondrial localization and interaction remain be explored. Here, we report our identification...
<div>Abstract<p>Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 convert from antiapoptotic a pro-apoptotic molecule. Nur77 posttranslational modification such as phosphorylation has been shown induce translocation nucleus mitochondria. However, small molecules that can bind directly trigger its mitochondrial localization and interaction remain be explored....
<p>The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 breast S3 lines but not non-transformed S4 did't induce body weight loss; Fi.g S5 overexpression Nur77-LBD enhances killing effect BI1071; S6 has no on other nuclear receptors; S7 imparied could be rescued by re-expression Bcl-2; S8 binding to Nur77 promotes interaction with Bcl-2 and mitochondrial localization</p>
<p>The Supplementary Methods show the Synthesis of DIM-C-pPhCF3+MeSO3- (BI1071); Figure S1 shows BI1071 induces apoptosis in different cancer cell lines; Fig. S2 breast S3 lines but not non-transformed S4 did't induce body weight loss; Fi.g S5 overexpression Nur77-LBD enhances killing effect BI1071; S6 has no on other nuclear receptors; S7 imparied could be rescued by re-expression Bcl-2; S8 binding to Nur77 promotes interaction with Bcl-2 and mitochondrial localization</p>
<div>Abstract<p>Nur77 (also called TR3 or NGFI-B), an orphan member of the nuclear receptor superfamily, induces apoptosis by translocating to mitochondria where it interacts with Bcl-2 convert from antiapoptotic a pro-apoptotic molecule. Nur77 posttranslational modification such as phosphorylation has been shown induce translocation nucleus mitochondria. However, small molecules that can bind directly trigger its mitochondrial localization and interaction remain be explored....
RXRα, a unique and important nuclear receptor, plays vital role in various biological pathological pathways including growth, differentiation apoptosis. We recently reported transcription-independent function of RXRα cancer cells which is phosphorylated by Cdk1 at the onset mitosis, resulting its translocation to centrosome, where (p -RXRα) interacts with polo-like kinase 1 (PLK1) promote centrosome maturation mitotic progression. Significantly, we also identified that small molecule XS-060...