A5088304835- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Advanced MRI Techniques and Applications
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Brain Metastases and Treatment
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Dementia and Cognitive Impairment Research
Zhongshan Hospital of Xiamen University
2014-2025
Tianjin Medical University General Hospital
2021-2024
Beijing University of Chinese Medicine
2023
Nanjing Drum Tower Hospital
2014-2023
Lanzhou University
2021
Zhongshan Hospital
2020
Xiamen University
2011-2020
Nanjing Medical University
2016-2020
Ministry of Education of the People's Republic of China
2018
Nanjing University
2014-2015
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of effective biomarkers for early detection HCC results in unsatisfactory curative treatments. Here, metabolite were identified and validated diagnosis. A total 1,448 subjects, including healthy controls patients with chronic hepatitis B virus infection, liver cirrhosis, HCC, recruited from multiple centers China. Liquid chromatography–mass spectrometry–based metabolomics methods used to characterize subjects'...
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to promoter activates YAP transcription. depletion of downregulates YAP, resulting a G1/S cell-cycle block increased cell death, both which are substantially rescued by reconstituting YAP. can be inactivated oxidative mechanisms, acetaminophen-induced...
Delivery of arsenic trioxide (ATO), a clinical anticancer drug, has drawn much attention to improve its pharmacokinetics and bioavailability for efficient cancer therapy. Real-time in situ monitoring ATO behaviors vivo is highly desirable tumor treatment. Herein, we report an ATO-based multifunctional drug delivery system that efficiently delivers treat tumors allows real-time release by activatable T1 imaging. We loaded water-insoluble manganese arsenite complexes, the prodrug, into hollow...
The immunosuppressive properties of hepatic stellate cells (HSCs) contribute to the occurrence and development hepatocellular carcinoma (HCC). accumulation with immune suppressive activities, such as myeloid-derived suppressor (MDSCs) regulatory T (Tregs) is a key mechanism for tumor evasion. However, impact HSCs on cell populations in tumor-bearing hosts unclear. In this study, we established an orthotopic liver mouse model studying complex tumor–host interactions HCC. activated promoted...
Emerging evidences have highlighted the roles of neutrophils, as major host microenvironment component, in development hepatocellular carcinoma (HCC). Neutrophils extracellular traps (NETs) produced infection can strengthen behavior cancer metastasis. Here, we investigated NETs HCC metastasis and further explore underlying mechanism how interact with cancer.The neutrophils were isolated from whole blood patients used to evaluate formation NETs. NET markers detected tissue samples, plasma...
We described the smart and targeted magnetic nanocarriers to control delivery release of anticancer drug doxorubicin (DOX) in vitro demonstrated that they can exhibit much higher cytotoxicity cancer cells than free DOX. The conjugation magnetite nanoparticles (∼14 nm diameter) DOX molecule via acid-labile imine bond endows with three advanced features: magnetically controllable, specific targeting, pH-responsive. cell toxicity assays indicated pH-sensitive (IC50 0.13 μg mL−1 HeLa cells) have...
Activated hepatic stellate cells (HSCs) play a central role in the fibrosis and cirrhosis. Recently, HSCs were reported to have strong immune modulatory activities. However, of hepatocellular carcinoma (HCC) remains unclear. In this study, we showed that could promote HCC growth both vitro vivo. We examined HSC-mediated inhibition T-cell proliferation ability conditioned medium from activated murine cell lines vitro. also assessed suppression by during development immunocompetent mice....
Hepatocellular carcinoma (HCC) is a common malignancy worldwide, which especially prevalent in Asia. Elucidating the molecular basis of HCC crucial to develop targeted diagnostic tools and novel therapies. Recent studies have identified AT-rich interactive domain-containing protein 1A (ARID1A) as broad-spectrum tumor suppressor. We evaluated clinical implications decreased ARID1A expression HCC, investigated mechanisms ARID1A-mediated suppression. Quantitative PCR, western blotting,...
RAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving E3 ligase Nedd4-1, Ras, and PTEN. We found that signaling stimulates expression of which turn acts as an ubiquitin regulates levels. Importantly, activation, either by oncogenic mutations or epidermal growth factor (EGF) signaling, prevents Nedd4-1-mediated ubiquitination. This leads to Ras-induced Nedd4-1...
Long noncoding RNAs (lncRNAs) are a new class of regulatory RNAs. Emerging evidences indicate that lncRNAs play critical role in the development hepatocellular carcinoma (HCC). Although several have been annotated, association most with HCC is unknown. In this study, we investigated lncRNA alterations by performing microarray analysis. We identified novel called HCC-associated (HCAL) was highly expressed tissues. HCAL upregulation clinically associated poor differentiation, intravascular...
Recent studies reveal that long non-coding RNAs (LncRNAs) play critical roles in the proliferation and migration of human cancer. Previous report has shown LncRNA HOXA-AS2 was involved carcinoma processes. However, expression biological function hepatocellular (HCC) are poorly understood.Quantitative real-time PCR (qRT-PCR) performed to detect HCC tissues cell lines. The relation between lncRNA clinicopathological characteristics assessed by chi-square test. prognosis analyzed using...
Significance Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Most studies have focused on epigenetic gene-silencing events; therefore, the mechanism that promotes activation HCC is not well established. We identify an whereby menin Yes-associated protein (Yap1) transcription, which a poor prognosis for patients. Substantial overexpression of menin–mixed-lineage leukemia complex increased histone 3 lysine 4 trimethylation...
// Yaping Xu 1,2,* , Wenxiu Zhao 1,* Jianfeng 1 Jie Li Zaifa Hong Zhenyu Yin and Xiaomin Wang Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory Chronic Liver Disease Hepatocellular Carcinoma (Xiamen University Affiliated Hospital), Xiamen, Fujian, China 2 Basic Medicine, Medicine College, * These authors have contributed equally to this work Correspondence to: Wang, email: Yin, Keywords : myeloid-derived suppressor cells, hepatic...
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Recently, ubiquitin-conjugating enzyme E2C (UBE2C) has been reported to be overexpressed in human cancers and act as a potential oncogene. However, little known about functional roles UBE2C HCC progression. In present study, analysis mRNA expression The Cancer Genome Atlas (TCGA) dataset reveals that significantly higher levels was found tissues associated with grade. Elevated indicated...
ABSTRACT The outbreak of novel coronavirus disease 2019 (COVID-19) has become a pandemic. Drug repurposing may represent rapid way to fill the urgent need for effective treatment. We evaluated clinical utility chloroquine and hydroxychloroquine in treating COVID-19. Forty-eight patients with moderate COVID-19 were randomized oral treatment (1000 mg QD on Day 1, then 500 9 days; n=18), (200 BID 10 or control (n=12). Adverse events mild, except one case Grade 2 ALT elevation. more commonly...
Abstract The immunomodulatory effect of divalent manganese cations (Mn 2+ ), such as activation the cGAS−STING pathway or NLRP3 inflammasomes, positions them adjuvants for cancer immunotherapy. In this study, it is found that trace Mn ions, bound to bovine serum albumin (BSA) form Mn@BSA nanocomplexes, stimulate pro‐inflammatory responses in human‐ murine‐derived macrophages through TLR4‐mediated signaling cascades. Building on this, assembly nanocomplexes obtain nanowire structures enables...
Abstract Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models neurological diseases. However, it remained unknown whether effective to prevent neuron loss. To systematically evaluate its effects, was used treat Dicer conditional knockout (cKO) mice which display age-related The drug given mutant prior the occurrence neuroinflammation and neurodegeneration treatment had...
Brain white matter fiber bundles in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) have abnormalities not usually seen unaffected subjects. Ideal algorithm of the localization-specific properties integrity might reveal changes tissue varying along each tract, while previous studies only detected mean DTI parameters fiber. The aim this study was to investigate whether these nerve tracts are localized specific regions or spread throughout analyze which examined...
The cross‐talk between hepatic stellate cells (HSCs) and carcinoma contributes to hepatocellular (HCC) progression, but the underlying mechanism is largely unknown. We report here that activated HSCs induce upregulation of nicotinamide N‐methyltransferase (NNMT), which known regulate multiple metabolic pathways in hepatoma liver. High levels NNMT HCC tissues were positively correlated with vascular invasion, increased serum HBV‐DNA levels, distant metastasis. In addition, functional assays...