A5068976750- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Advanced Breast Cancer Therapies
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Membrane Separation Technologies
- Solar-Powered Water Purification Methods
- HER2/EGFR in Cancer Research
- Wnt/β-catenin signaling in development and cancer
- Synthesis and biological activity
- Solar Thermal and Photovoltaic Systems
- T-cell and B-cell Immunology
- Neonatal and fetal brain pathology
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Lipid metabolism and biosynthesis
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Educational Reforms and Innovations
- Neurological Disease Mechanisms and Treatments
- Cellular Mechanics and Interactions
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
Xiamen University
2014-2024
Yangzhou University
2021-2024
Agency for Science, Technology and Research
2023
Institute of Molecular and Cell Biology
2023
National Cheng Kung University
2021
Weifang Medical University
2018-2021
Toxicologie, Pharmacologie et Signalisation Cellulaire
2020
Xiamen University of Technology
2020
Beijing Health Vocational College
2016
Brigham and Women's Hospital
2008-2013
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting 3 (Rip3) and be essential for tumor necrosis factor (TNF)-induced programmed (necroptosis) in cultured cell lines. We have generated Mlkl-deficient mice by transcription activator-like effector nucleases (TALENs)-mediated gene disruption Mlkl dispensable normal mouse development as well immune development. embryonic fibroblasts (MEFs) macrophages both showed resistance necrotic but not...
Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor kinase MST1/2 provides therapeutic option for tissue injury repair.
Abstract Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective such potential damage from oxidative stress remains unclear. Here we show that kinases Mst1 and Mst2 (Mst1/2) sense ROS maintain redox balance by modulating stability of antioxidant transcription factor Nrf2. Site-specific release recruits Mst1/2 cytosol to phagosomal or mitochondrial membrane, with subsequently activating phosphorylate kelch...
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate cells encounter different mechanical cues both health and disease adapt their behaviors. However, impact of sensing signals on signal-mediated remains unclear. Here we show that signalling augments macrophage bactericidal activity through sensor Piezo1. Bacterial infection or LPS stimulation triggers assembly complex Piezo1 remodel F-actin organization augment phagocytosis, mitochondrion-phagosomal...
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss Mst1/2, mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably enlarged endoplasmic reticulum (ER) size-associated UPR. Intriguingly, attenuation UPR by tauroursodeoxycholic acid (TUDCA) diminishes Mst1/2 mutant-driven liver overgrowth and tumorigenesis promoting nuclear exit degradation downstream effector Yap. Yap is required for activity ER expansion...
The Mst1 and Mst2 protein kinases are the mammalian homologs of hippo, a major inhibitor cell proliferation in Drosophila. is most abundant lymphoid tissues. Mice lacking exhibit markedly reduced levels regulatory Nore1B/RAPL cells, whereas abundance unaltered. Mst1-null mice normal T development but low numbers mature naïve cells with relatively effector/memory cells. In vitro , Mst1-deficient greater response to stimulation receptor proliferative responses cohort similar wild type. Thus,...
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to promoter activates YAP transcription. depletion of downregulates YAP, resulting a G1/S cell-cycle block increased cell death, both which are substantially rescued by reconstituting YAP. can be inactivated oxidative mechanisms, acetaminophen-induced...
The cytokine interleukin-1β (IL-1β) is critical to the formation of an astrocytic scar after CNS injury, but mechanisms by which it induces a reactive phenotype remain unresolved. Here, we show that IL-1β regulates astrocytes via deactivation Rho GTPase–Rho kinase (ROCK) pathway, governs cellular morphology and migration effects on F-actin its interactions with focal adhesions, nonmuscle myosin, microvillar adapter proteins ezrin–radixin–moesin (ERM) family. We found induced cortical...
Focal cerebral ischemia and traumatic brain injury induce an escalating amount of cell death because harmful mediators diffusing from the original lesion site. Evidence suggests that healthy cells surrounding these lesions attempt to protect themselves by producing endocannabinoids (eCBs) activating cannabinoid receptors, molecular target for marijuana-derived compounds. Indeed, activation receptors reduces production diffusion mediators. Here, we provide evidence exception this pattern is...
The purinergic receptor P2X7R is a nucleotide-gated ion channel that has been proposed to function as major regulator of inflammation. In this study we examined the role in regulating inflammation CNS by determining effects loss (P2X7R-/-) on experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. We show here P2X7R-/- mice developed more severe clinical and pathological expression EAE than wild type (WT) controls spleen lymph node cells from proliferated...
The Hippo signaling pathway has emerged as a critical regulator for organ size control. serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the kinase from Drosophila, play central roles in controlling cell proliferation, differentiation, apoptosis during development. Mst1/2 can be activated by cellular stressors activation might enforce feedback stimulation system to regulate oxidant levels through several mechanisms, which regulation redox state represent tumor suppressor...
Abstract Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for synthesis of glycerolipids, interacts with is a direct substrate Src proto-oncogenic tyrosine kinase. Obesity-associated microenvironmental factors other Src-activating growth factors, including epidermal factor, activate promote...
Ultra-small palladium nanosheets are employed as the safe carriers of immunoadjuvant CpG for highly efficient cancer photothermal combined immunotherapy.
Abstract The long cytoplasmic tail (CT) isoforms of carcinoembryonic Ag-related cell adhesion molecule 1 (CEACAM1) are expressed on activated human T cells and possess two ITIM motifs in the CT. These CEACAM1 inhibitory for responses initiated by TCR/CD3 complex with inhibition dependent upon ITIMs Src homology 2 domain-containing phosphatase (SHP-1). However, mechanism which this occurs is unknown. We demonstrate here that family kinase, Lck, ability to bind homophilically required...