A5044880779- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Infective Endocarditis Diagnosis and Management
- Systemic Lupus Erythematosus Research
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Antioxidant Activity and Oxidative Stress
- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Advanced Biosensing Techniques and Applications
- Erythropoietin and Anemia Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Blood transfusion and management
- Healthcare cost, quality, practices
- Cardiac pacing and defibrillation studies
- Antimicrobial Resistance in Staphylococcus
German Cancer Research Center
2025
Heidelberg University
2025
Lung Institute
2016-2024
Imperial College London
2016-2024
Imperial College Healthcare NHS Trust
2016-2024
Hammersmith Hospital
2018-2024
Health Data Research UK
2022-2023
NIHR Imperial Biomedical Research Centre
2019-2022
Harefield Hospital
2017
Royal Brompton & Harefield NHS Foundation Trust
2017
Adiponectin is a plasma protein expressed exclusively in adipose tissue. levels are linked to insulin sensitivity, but direct effect of chronically elevated adiponectin on improved sensitivity has not yet been demonstrated. We identified dominant mutation the collagenous domain that circulating values mice by 3-fold. Adiponectinemia raised lipid clearance and lipoprotein lipase activity, suppressed insulin-mediated endogenous glucose production. The induction during puberty sexual dimorphism...
Background— Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role global public health. Methods Results— Ischemic heart disease cerebrovascular age-standardized death rates (as per International Classification Diseases , ninth tenth revisions) were collated from the World Health Organization database for member states European Union. characterized by using Joinpoint regression analysis. An...
RNA binding proteins may be important mediators of the activity-dependent transport mRNAs to dendritic spines activated synapses. We used fluorescence microscopy and digital imaging techniques applied both fixed live cultured hippocampal neurons visualize localization mRNA protein, zipcode protein 1 (ZBP1), its dynamic movements in response KCl-induced depolarization at high spatial temporal resolution. With use immunofluorescence, image deconvolution, three-dimensional reconstruction, ZBP1...
The cytokine interleukin-1β (IL-1β) is critical to the formation of an astrocytic scar after CNS injury, but mechanisms by which it induces a reactive phenotype remain unresolved. Here, we show that IL-1β regulates astrocytes via deactivation Rho GTPase–Rho kinase (ROCK) pathway, governs cellular morphology and migration effects on F-actin its interactions with focal adhesions, nonmuscle myosin, microvillar adapter proteins ezrin–radixin–moesin (ERM) family. We found induced cortical...
Background There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients advanced cardiovascular (CV) therapies in modern era. The prognostic value mildly elevated hsCRP beyond troponin large real-world cohort unselected presenting with suspected acute coronary syndrome (ACS) unknown. We evaluated whether (up to 15 mg/L) was associated mortality risk, level, ACS. Methods and findings conducted retrospective study based National...
Global longitudinal strain (GLS) is reported to be more reproducible and prognostic than ejection fraction. Automated, transparent methods may increase trust uptake. The authors developed open machine-learning–based GLS methodology validate it using multiexpert consensus from the Unity UK Echocardiography AI Collaborative. We trained a multi-image neural network (Unity-GLS) identify annulus, apex, endocardial curve on 6,819 apical 4-, 2-, 3-chamber images. external validation dataset...
<title>Abstract</title> Background The kidney's endocrine function is essential for maintaining body homeostasis. Erythropoietin (EPO) one of the key factors produced by kidney, and kidney disease patients frequently experience anemia due to impaired EPO production. In present study we explored potential human induced pluripotent stem cell (iPSC)-derived organoids restore Methods secretion was examined under 1% 20% oxygen levels. To increase secreting capacity organoids, iPSC were...
The Purkinje network is essential for normal electrical impulse propagation in the heart but has also been implicated ventricular arrhythmias. Previous experimental work suggested that not all Purkinje-myocardial junctions (PMJs) are active at rest due to source-sink mismatch PMJs. We hypothesized pathological conditions cause gap junction uncoupling (e.g., acute ischaemia), would increase number of PMJs, leading more complex activation patterns. investigated this using a whole-heart intact...
BackgroundCertain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis.ObjectivesWe tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) associated with clinical coronary heart disease (CHD) unfavorable plaque characteristics.MethodsNORDIL was a prospective study investigating adverse cardiovascular outcomes hypertensive patients. IBIS-3 analyzed lesions non-culprit artery <50% stenosis using...
Pulmonary hypertension (PH) is an independent risk factor for morbidity and mortality. In the last two decades, significant advances have been made in management of World Health Organization (WHO) group 1 PH. However, there are no approved targeted pharmacotherapies PH secondary to left-sided heart diseases or chronic hypoxic lung which thought account more than 70-80% disease burden. No recent investigation has analyzed compared mortality burden related WHO with groups 2-5 at national level...
Summary The evaluation of a radioimmunoassay for erythropoietin developed using recombinant material as immunogen and radiotracer is presented. A series serum samples prepared stored under varying conditions showed that immunoreactive levels were stable at room temperature least 10 days – 20°C 5 months. optimum time separating sera from was between 6 24 h after venepuncture. Serum EPO values significantly higher than those measured in heparin or potassium EDTA plasma.
There is an evolving need to evaluate atrial fibrillation/atrial flutter (AF/AFL) mortality trends across races, sexes, geographic regions and urbanization statuses better understand management inequalities.This observational study utilized the Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiologic Research (CDC WONDER) database. Mortality rates due AF/AFL as underlying contributing causes of death between 2010 2020 were investigated. different census analyzed using...
Serial serum erythropoietin levels were measured in 10 consecutive patients undergoing allogeneic bone marrow transplantation. Observed are compared with those predicted from a large control population of anaemic not receiving chemotherapy. There was an initial acute rise erythropoietin, peaking between days 1 and 4 after transfusion, which unrelated to changes haemoglobin concentration. Patients maintained concentrations at around twice the level for first 2 weeks following transplantation,...