A5031918962- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- GDF15 and Related Biomarkers
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Adipokines, Inflammation, and Metabolic Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Signaling Pathways in Disease
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Aortic aneurysm repair treatments
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
Erasmus MC Cancer Institute
2016-2024
VieCuri Medisch Centrum
2017
Noordwest Ziekenhuisgroep
2016
Netherlands Heart Institute
2014-2016
Inserm
2014
Centre de Recherche des Cordeliers
2014
Sorbonne Université
2000-2014
Centre National de la Recherche Scientifique
2014
Background —Appropriate treatment policies should include an accurate estimate of a patient’s baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes without persistent ST-segment elevation. Methods and Results —We analyzed the relation between characteristics 30-day incidence death composite or myocardial (re)infarction 9461 elevation enrolled PURSUIT trial [Platelet glycoprotein IIb/IIIa Unstable angina: Receptor Suppression Using Integrilin...
Acute coronary syndromes (ACS) are mostly caused by plaque rupture. This study aims to investigate the prognostic value of in vivo detection high-risk plaques intravascular ultrasound (IVUS) patients undergoing angiography. Between November 2008 and January 2011, IVUS a non-culprit artery was performed 581 who underwent angiography for ACS (n = 318) or stable angina 263). Primary endpoint major adverse cardiac events (MACEs) defined as mortality, ACS, unplanned revascularization. Culprit...
Background —A proportion of patients who present with suspected acute coronary syndrome (ACS) are found to have insignificant artery disease (CAD) during angiography, but these not been well characterized. Methods and Results —Of the 5767 non–ST-segment elevation ACS were enrolled in Platelet Glycoprotein IIb/IIIa Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial underwent in-hospital 88% had significant CAD (any stenosis >50%), 6% mild >0%...
We investigated the associations of ten previously identified high risk molecular lipid species and three ceramide ratios with occurrence major adverse cardiac events (MACEs) during a median follow-up 4.7 years in patients coronary artery disease (CAD). Between 2008 2011, 581 underwent diagnostic angiography or percutaneous intervention for stable angina pectoris (SAP) acute syndrome (ACS). Blood was drawn prior to index procedure were determined. The primary endpoint MACE, comprising...
To evaluate sublingual microcirculatory and peripheral tissue perfusion parameters in relation to systemic hemodynamics during after therapeutic hypothermia following out-of-hospital cardiac arrest.Prospective observational study.Intensive care unit at a university teaching hospital.We followed 80 patients, of whom 25 were included arrest.In all we induced 33°C the first 24 hrs admission.Complete hemodynamic measurements obtained directly on intensive admission (baseline), (T1), rewarming...
Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). We studied prognostic value of NIRS-derived LCBI in patients with artery disease (CAD) for adverse cardiac outcome during long-term follow-up. During 2009–2013, NIRS was performed a non-culprit 275 undergoing angiography acute syndrome (ACS) or stable angina. quantified an independent corelab region interest (LCBIROI) and 4 10 mm long segment maximum (MaxLCBI4mm...
The relevance of the adverse prognostic implications CK-MB elevation after percutaneous coronary intervention (PCI) remains controversial. Therefore, we compared relationship between level postprocedural and 6-month mortality in patients undergoing PCI with spontaneous, non-PCI-related acute syndromes (ACS) treated medically.In PURSUIT trial, 5583 9461 who presented a non-ST-elevation ACS did not undergo or CABG had at least 1 sample collected during index-hospitalization. There was gradual...
To study temporal trends in short- and long-term outcome after myocardial infarction (MI) according to diabetes status.We included all 14,434 consecutive patients admitted for ST-segment elevation MI or non-ST-segment at our center between 1985 2008. The were compared prevalent diabetes. Temporal trend analyses performed by comparing decades of admission (1985-1989 vs. 1990-1999 2000-2008).A total 2,015 (14%) the had risk presenting with increased from 8 17% Diabetic presented a higher...
HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based subphenotypes and investigate underlying dynamic biological mechanisms. Herewith we aimed gain pathophysiological insights fuel opportunities for personalised treatment.In 382 patients, performed trimonthly blood sampling during median follow-up 2.1 [IQR:1.1-2.6] years. selected all baseline samples two closest the primary endpoint (PEP;...
<h3>Objective</h3> To evaluate the predictive value of seven biomarkers, which individually have been shown to be independent predictors, for use in a combined multimarker model long-term cardiovascular outcome after non-ST-segment elevation acute coronary syndrome (NSTEACS). <h3>Design and Setting</h3> Levels high-sensitivity C-reactive protein (hsCRP), myeloperoxidase, pregnancy-associated plasma A, placental growth factor (PlGF), soluble CD40 ligand (sCD40L), interleukin 10 (IL-10)...
Objective— Previous proteomics experiments have demonstrated that several proteins are differentially expressed in vulnerable human carotid plaques compared with stable plaques. This study aims to investigate the prognostic value of 13 such circulating biomarkers patients coronary artery disease. Approach and Results— Between 2008 2011, 768 who underwent angiography for acute syndrome or angina pectoris were included a prospective biomarker study. Plasma concentrations measured 88...
Studies on serially measured GDF-15 (growth differentiation factor 15) in acute heart failure (HF) are limited. Moreover, several pathophysiological pathways contribute to HF. Therefore, we aimed explore the (additional) prognostic value of using a multi-marker approach more accurately predict HF risk.TRIUMPH (Translational Initiative Unique and Novel Strategies for Management Patients With Heart Failure) is prospective cohort 496 patients with who were enrolled 14 hospitals Netherlands...