A5070116576- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- GDF15 and Related Biomarkers
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Cystic Fibrosis Research Advances
- Peripheral Artery Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Peptidase Inhibition and Analysis
- Cardiovascular Health and Disease Prevention
- Hormonal and reproductive studies
- Cardiac pacing and defibrillation studies
- Medication Adherence and Compliance
- Cancer Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Lung Cancer Treatments and Mutations
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Apelin-related biomedical research
- Cardiac tumors and thrombi
British Heart Foundation
2025
University of Edinburgh
2024-2025
Erasmus MC
2019-2024
Erasmus MC Cancer Institute
2024
Erasmus University Rotterdam
2022
University Hospital Heidelberg
2018
University Medical Center Utrecht
2018
Utrecht University
2018
Heidelberg University
2018
Pharmo Institute
2017
The effects of testosterone on cardiovascular disease (CVD) as reported in literature have been ambiguous. Recently, the interplay between and oestradiol assessed by testosterone/oestradiol (T/E2) ratio was suggested to be better informative normal physiological balance. Considering role CVD, we hypothesized that a low T/E2 men with CVD is associated increased inflammation, more unstable plaque worse outcome. Testosterone concentrations were determined blood samples 611 male carotid...
Cardiac troponin concentrations are lower in women than men. We examined whether age- and risk factor-related changes cardiac over the life course differ by sex if trajectory of was informative respect cardiovascular outcomes men general population.
HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based subphenotypes and investigate underlying dynamic biological mechanisms. Herewith we aimed gain pathophysiological insights fuel opportunities for personalised treatment.In 382 patients, performed trimonthly blood sampling during median follow-up 2.1 [IQR:1.1-2.6] years. selected all baseline samples two closest the primary endpoint (PEP;...
Abstract The aim of our observational study was to derive a small set out 92 repeatedly measured biomarkers with optimal predictive capacity for adverse clinical events in heart failure, which could be used dynamic, individual risk assessment practice. In 250 chronic HFrEF (CHF) patients, we collected trimonthly blood samples during median 2.2 years. We selected 537 repeated measurement the Cardiovascular Panel III (Olink Proteomics AB). applied Least Absolute Shrinkage and Selection...
Abstract Background High-sensitivity cardiac troponin testing is a promising tool for cardiovascular risk prediction, but whether serial can dynamically predict uncertain. We evaluated the trajectory of I in years prior to event general population, and determine measurements could track within individuals. Methods In Whitehall II cohort, high-sensitivity concentrations were measured on three occasions over 15-year period. Time trajectories constructed those who died from disease compared...
Abstract Background Emerging evidence suggests that the ratio between cardiac troponin (cTn) I and T may provide information on risk of adverse outcomes in individuals with cardiovascular disease. Whether cTn I/T provides prognostic insights general population is unknown. Methods The was calculated 8855 participants (43% female, median age 56 years) from Generation Scotland Study where both cTnI cTnT concentrations were above limit blank. Multivariable cause-specific Cox proportional hazard...
Abstract Background Following myocardial infarction, secondary preventative medication is recommended to reduce residual cardiovascular risk. Insights into the short- and long-term trends in provision of guideline-directed medical therapies by sex, age, ethnicity social deprivation may help identify inequalities contemporary post-myocardial infarction care. Purpose To evaluate patterns patients following age categories, groups. Methods This observational cohort study using linked routine...
Background and aimsThe sex- age-related differences in the composition of iliofemoral atherosclerotic plaques are largely unknown. Therefore, aim current study is to gain insight into plaque across strata age sex a large cohort vascular surgery patients.MethodsPeripheral patients who underwent endarterectomy (n = 790) were harvested between 2002 2014. The semi-quantitatively analyzed for presence lipid cores, calcifications, hemorrhages (PH), collagen, macrophage smooth muscle cell (SMC)...
Abstract Background Studies focusing on sex differences in circulating proteins patients with heart failure reduced ejection fraction (HFrEF) are scarce. Insight into sex-specific cardiovascular protein profiles and their associations the risk of adverse outcomes may contribute to a better understanding pathophysiological processes involved HFrEF. Moreover, it could provide basis for use measurements prognostication women men, wherein most relevant applied each sexes. Methods In 382 HFrEF,...
Risk assessment tools are needed for timely identification of patients with heart failure (HF) reduced ejection fraction (HFrEF) who at high risk adverse events. In this study, we aim to derive a small set out 4210 repeatedly measured proteins, which, along clinical characteristics and established biomarkers, carry optimal prognostic capacity events, in HFrEF.In 382 patients, performed repeated blood sampling (median follow-up: 2.1 years) applied an aptamer-based multiplex proteomic...
This study aims to provide insight into sex-specific cardiovascular protein profiles and their associations with adverse outcomes, which may contribute a better understanding of heart failure (HF) pathophysiology the optimal use circulating proteins for prognostication in women men.
We investigated whether repeatedly measured global longitudinal strain (GLS) has incremental prognostic value over left ventricular ejection fraction (LVEF) and N-terminal pro B-type natriuretic peptide (NT-proBNP), a single "baseline" GLS value, in chronic heart failure (HF) patients.In this prospective observational study, echocardiography was performed 173 clinically stable HF patients every six months during follow up. During median follow-up of 2.7 years, 3 (25th-75th percentile:2-4)...
We aimed to identify patients with subphenotypes of postacute coronary syndrome (ACS) using repeated measurements high-sensitivity cardiac troponin T, N-terminal pro-B-type natriuretic peptide, C-reactive protein, and growth differentiation factor 15 in the year after index admission, investigate their association long-term mortality risk.
Abstract Objective Heart failure (HF) pathophysiology in patients with obesity may be distinct. To study these features, we identified obesity‐related biomarkers from 4210 circulating proteins HF reduced ejection fraction (HFrEF) and examined associations of prognosis biological mechanisms. Methods In 373 trimonthly blood sampling during a median follow‐up 2.1 (25th–75th percentile: 1.1–2.6) years, applied an aptamer‐based multiplex approach measuring baseline samples the last two before...
Insights in age- and sex-specific coronary atherosclerotic plaque characteristics may contribute to a better understanding of artery disease and, ultimately, its prevention treatment. In 307 women 406 men aged 20 90 years undergoing intravascular ultrasound imaging, sex-based differences were mainly present younger patients, while these less pronounced at advanced age.
Introduction Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level varies. Because close temporal relationship with vascular injury, longitudinal measurements circulating endothelial cells (CECs) carry potential to improve individual assessment.Methods We conducted explorative nested case-control study within our multicenter, prospective, observational biomarker (BIOMArCS) 844 ACS patients. Following index ACS, high-frequency blood...
Abstract Background Cardiac troponin is a promising biomarker that may improve cardiovascular risk prediction. Previously, important differences have been demonstrated between cardiac concentration in women and men. At this point, it unknown whether changes over the life course differ men impacts Purpose Insights into sex-specific trajectories how these are influenced by factors necessary to ensure approaches prevention of disease equitable. Therefore, we examined age- factor-related sex if...
Abstract Background High-sensitivity cardiac troponin may be a promising biomarker that could used for personalised cardiovascular risk prediction and monitoring in the general population. Temporal changes high-sensitivity before death are largely unexplored. Purpose Using longitudinal Whitehall II cohort, we evaluated whether three serial I measurements over 15 years improved of when compared to single time point at baseline. Methods is an ongoing observation cohort study 10,308 civil...