A5091411029- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Systemic Lupus Erythematosus Research
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Genetic diversity and population structure
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Atrial Fibrillation Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Venous Thromboembolism Diagnosis and Management
- Evolution and Genetic Dynamics
- Coronary Interventions and Diagnostics
- Sodium Intake and Health
- Stroke Rehabilitation and Recovery
- Biomarkers in Disease Mechanisms
Leiden University Medical Center
2023-2024
Erasmus MC
2014-2023
Northwest Hospital
2018-2023
Leiden University
2023
Naturalis Biodiversity Center
2023
Netherlands Heart Institute
2016-2022
Erasmus University Rotterdam
2018-2020
Erasmus MC - Sophia Children’s Hospital
2017
Noordwest Ziekenhuisgroep
2016
Vejle Sygehus
2012
Abstract Aims In a large proportion of heart failure with reduced ejection fraction (HFrEF) patients, echocardiographic estimation left atrial pressure (LAP) is not possible when the ratio peak early ventricular filling velocity over late (E/A ratio) available, which may occur due to several potential causes. Left reservoir strain (LASr) correlated LV pressures and serve as an alternative parameter in these patients. The aim this study was determine whether LASr can be used estimate LAP...
Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) associated with clinical coronary heart disease (CHD) unfavorable plaque characteristics. NORDIL was a prospective study investigating adverse cardiovascular outcomes hypertensive patients. IBIS-3 analyzed lesions non-culprit artery <50% stenosis using radiofrequency intravascular...
Importance MR CLEAN-LATE (Multicenter Randomized Clinical Trial of Endovascular Treatment Acute Ischemic Stroke in the Netherlands for Late Arrivals) showed efficacy endovascular treatment (EVT) late window (6-24 hours after stroke symptom onset or time last seen well) among patients with ischemic selected based on collateral flow. Therefore, future role computed tomography perfusion (CTP) imaging patient selection late-window EVT may change. Objective To investigate interaction CTP...
Cardiovascular inflammation and vascular endothelial dysfunction are involved in chronic heart failure (CHF), cellular adhesion molecules considered to play a key role these mechanisms. We evaluated temporal patterns of 12 blood biomarkers cell patients with CHF. In 263 ambulant patients, serial, tri-monthly samples were collected during median follow-up 2.2 (1.4–2.5) years. The primary endpoint (PE) was composite cardiovascular mortality, HF hospitalization, transplantation implantation...
When two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized banded newt (genus
Microcirculatory visualization has already been used to investigate buccal and cutaneous microcirculatory alterations in neonates. Still, the reproducibility of these microvascular measurements never studied (premature) This study aimed determine vessel density SDF clips one-day-old term newborns.Buccal microcirculations were measured using imaging. Vessel was independently assessed by two investigators. Reproducibility from ICC Bland-Altman analysis.Reproducibility assessment area good,...
Abstract Objective This article investigates whether longitudinally measured fibrinolysis factors are associated with cardiac events in patients chronic heart failure (CHF). Methods A median of 9 (interquartile range [IQR] 5–10) serial, tri-monthly blood samples per patient were prospectively collected 263 CHF during a follow-up 2.2 (IQR 1.4–2.5) years. Seventy (cases) reached the composite endpoint death, hospitalization, left ventricular assist device, or transplantation. From all...
Abstract Objectives Details of the biological variability high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone brain natriuretic peptide (NT-proBNP) and ST2 are currently lacking in patients with acute coronary syndrome (ACS) but crucial knowledge when aiming to use these biomarkers for personalized risk prediction. In current study, we report post-ACS kinetics hs-CRP, NT-proBNP ST2. Methods BIOMArCS is a prospective, observational study high frequency blood sampling during 1...
The Biomarker Study to Identify the Acute Risk of a Coronary Syndrome (BIOMArCS) is prospective, observational study that has been designed evolution blood biomarkers in post-acute coronary syndrome (ACS) patients. In our recently published "Temporal Myeloperoxidase and Galectin 3 during 1 year after acute admission" [1] American Heart Journal, we demonstrated repeatedly measuring MPO Galectin-3 does not aid differentiate between patients with without adverse cardiac events 1-year follow-up....
We investigated whether repeatedly measured global longitudinal strain (GLS) has incremental prognostic value over left ventricular ejection fraction (LVEF) and N-terminal pro B-type natriuretic peptide (NT-proBNP), a single "baseline" GLS value, in chronic heart failure (HF) patients.In this prospective observational study, echocardiography was performed 173 clinically stable HF patients every six months during follow up. During median follow-up of 2.7 years, 3 (25th-75th percentile:2-4)...
To further elucidate the nature of association between N-terminal pro-B type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-TnT), C-reactive protein (CRP), and clinical outcome, we examined relationship serial simultaneous measurements echocardiographic parameters these biomarkers in chronic heart failure (CHF) patients.In 117 CHF patients with ejection fraction ≤50%, NT-proBNP, hs-TnT, CRP were measured simultaneously evaluation at 6-month intervals until end 30...
The aim was to assess the reproducibility of Pleth Variability Index (PVI), developed for non-invasive monitoring peripheral perfusion, in preterm neonates below 32 weeks gestational age. Three PVI measurements were consecutively performed stable, comfortable first 48 h life. On each occasion, pulse oximeter sensors attached two different limbs 5 min. Reproducibility assessed with intra-class correlation coefficient (ICC) and Bland-Altman analysis. A total 25 included. Inter-limb comparison...
Abstract Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and temporal patterns of provide other echocardiographic markers NT-proBNP. Methods In this prospective observational study, 153 underwent 6-monthly echocardiography, during median follow-up 2.5 years. Speckle tracking echocardiography was used to measure...
Higher soluble ST2 (sST2) levels at admission are associated with adverse outcome in acute coronary syndrome (ACS) patients. We studied the dynamics of sST2 over time post-ACS patients prior to a recurrent ACS or cardiac death.We used BIOMArCS case cohort, consisting 187 who underwent serial blood sampling during one-year follow-up post-ACS. was batch-wise quantified after completion median 8 (IQR: 5-11) samples per patient. Joint modelling investigate association between longitudinally...
BackgroundImpaired renal function predicts mortality in acute coronary syndrome (ACS), but its evolution immediately following index ACS and preceding next has not been described detail. We aimed to describe this using serial measurements of creatinine, glomerular filtration rate [eGFRCr] cystatin C [CysC].MethodsFrom 844 patients included the BIOMArCS study, we analysed patient-specific longitudinal marker trajectories from case-cohort 187 determine risk endpoint (cardiovascular death or...
Background Detailed insights in temporal evolution of high-sensitivity cardiac troponin following acute coronary syndrome (ACS) are currently missing. We aimed to describe and compare the post-ACS kinetics I (hs-cTnI) T (hs-cTnT), determine their intra- interindividual variation clinically stable patients. Methods Results determined hs-cTnI (Abbott) hs-cTnT (Roche) 1507 repeated blood samples, derived from 191 patients with ACS (median, 8/patient) who remained free adverse events during...
We aimed to investigate if major vascular surgery induces LDL oxidation, and whether circulating antibodies against malondialdehyde-modified (MDA-LDL) alter dynamically in this setting. also questioned relationships between these biomarkers post-operative cardiovascular events. Major can induce an oxidative stress response. However, the role of humoral immune system clearance oxidized following such insult is unknown. Plasma samples were obtained from a prospective cohort 131 patients...
Background and aims: The Cytocam is a new generation Incident darkfield imaging (IDF) based handheld microscope for bedside visualization quantification of microcirculatory alterations. may be viewed as technolocigal successor the sidestream (SDF) device, currently most used device measurements. Aims: purpose this study to validate its use in transcutaneous measurements preterm neonates. We hypothesized that IDF produces higher quality images neonates resulting computed vessel density....