Jan W. Hoving
A5048814184- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Stroke Rehabilitation and Recovery
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Artery Disease Management
- Cerebral Venous Sinus Thrombosis
- Medical Imaging and Analysis
- Radiopharmaceutical Chemistry and Applications
- Orthopaedic implants and arthroplasty
- Brain Tumor Detection and Classification
- Health and Medical Studies
- Esophageal and GI Pathology
- MRI in cancer diagnosis
- Restraint-Related Deaths
- Diet and metabolism studies
- Radiation Dose and Imaging
- Shoulder and Clavicle Injuries
- Advanced MRI Techniques and Applications
- Ion Transport and Channel Regulation
- Intracranial Aneurysms: Treatment and Complications
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2017-2025
Amsterdam UMC Location University of Amsterdam
2017-2023
Amsterdam Neuroscience
2023
The Royal Melbourne Hospital
2018-2019
The University of Melbourne
2018-2019
Medisch Centrum Leeuwarden
1991-1999
University of Groningen
1977
Background and Purpose- The volume of estimated ischemic core using computed tomography perfusion (CTP) imaging can identify stroke patients who are likely to benefit from reperfusion, particularly beyond standard time windows. We assessed the accuracy pretreatment CTP in with successful endovascular reperfusion. Methods- Patients HERMES (Highly Effective Reperfusion Evaluated Multiple Endovascular Stroke Trials) EXTEND-IA TNK (Tenecteplase Versus Alteplase Before Therapy for Ischemic...
Thrombus radiomics (TR) describe complex shape and textural thrombus imaging features. We aimed to study the relationship of TR extracted from non-contrast CT with procedural functional outcome in endovascular-treated patients acute ischemic stroke.Thrombi were segmented on thin-slice (≤1 mm) 699 included MR CLEAN Registry. In a pilot study, we selected 51 consistent values across two raters' segmentations (ICC >0.75). Random forest models using addition or as substitute baseline clinical...
Abstract Objectives This study aims to: (1) develop and evaluate a quantitative assessment of collateral status in the downstream area an occluded intracranial artery acute ischemic stroke compare this method to middle cerebral (MCA)-based assessment; (2) determine agreement between automated occlusion-downstream score (ODACS) expert raters’ assessments, inter-rater agreement. Methods Patients from MR CLEAN-NO IV CLEAN Registry with proximal M1, distal or M2 occlusion were included. Using...
Importance MR CLEAN-LATE (Multicenter Randomized Clinical Trial of Endovascular Treatment Acute Ischemic Stroke in the Netherlands for Late Arrivals) showed efficacy endovascular treatment (EVT) late window (6-24 hours after stroke symptom onset or time last seen well) among patients with ischemic selected based on collateral flow. Therefore, future role computed tomography perfusion (CTP) imaging patient selection late-window EVT may change. Objective To investigate interaction CTP...
Background and Purpose: Cerebral edema elevated intracranial pressure (ICP) are the leading cause of death in first week following stroke. Despite this, current treatments limited fail to address underlying mechanisms swelling, highlighting need for targeted treatments. When screening promising novel agents, it is essential use clinically-relevant large animal models increase likelihood successful clinical translation. As such, we sought develop a survival model transient middle cerebral...
Infarct volume (FIV) on follow-up diffusion-weighted imaging (FU-DWI) is only moderately associated with functional outcome in acute ischemic stroke patients. However, FU-DWI may contain other biomarkers that could aid improving prediction models for stroke. We included data from the HERMES, ISLES, and MR CLEAN-NO IV databases. Lesions were segmented using a deep learning model trained HERMES ISLES datasets. assessed performance of three classifiers predicting independence trial cohort based...
Thrombus imaging characteristics are associated with treatment success and functional outcomes in stroke patients. However, assessing these based on manual annotations is labor intensive subject to observer bias. Therefore, we aimed create an automated pipeline for consistent fast full thrombus segmentation. We used multi-center, multi-scanner datasets of anterior circulation patients baseline NCCT CTA training (n = 228) testing 100). first found the occlusion location using StrokeViewer LVO...
Background and Purpose: The morbidity early mortality associated with stroke is largely attributable to cerebral edema elevated intracranial pressure (ICP). Existing pharmacotherapies do not target the underlying pathophysiology are often ineffective in sustainably lowering ICP, whilst decompressive craniectomy (DC) surgery life-saving yet surgical/peri-operative risk increased elderly. Accordingly, there an urgent need for therapies that directly mechanisms of genesis. Neurogenic...
Abstract Purpose Acute stroke patients presenting with a distal internal carotid artery occlusion and patent terminus, allowing for collateral flow via the circle of Willis, may have more favorable natural history. Therefore, benefit endovascular treatment (EVT) is less evident. We performed an exploratory analysis EVT results compared to conservative in ‘carotid-I’ occlusions. Methods report on EVT-treated non-EVT-treated carotid-I occlusions from MR CLEAN Registry, trial, our comprehensive...
Background: A considerable proportion of acute ischemic stroke patients treated with endovascular thrombectomy (EVT) are dead or severely disabled at 3 months despite successful reperfusion. Ischemic core imaging biomarkers may help to identify who more likely have a poor outcome after We studied the association CT perfusion-(CTP), angiography-(CTA), and non-contrast CT-(NCCT) based markers in underwent EVT daily clinical practice. Methods: included EVT-treated (July 2016-November 2017) an...
Computed tomography perfusion (CTP) is widely used in the evaluation of acute ischemic stroke patients for endovascular thrombectomy (EVT). The stability CTP core estimation suboptimal and varies between software packages. We aimed to quantify volumetric spatial agreement follow-up infarct four approaches using syngo.via.
Background: A larger thrombus in patients with acute ischemic stroke might result more complex endovascular treatment procedures, resulting poorer patient outcomes. Current evidence on volume and length related to procedural functional outcomes remains contradicting. This study aimed assess the prognostic value of whether this relationship differs between first-line stent retrievers aspiration devices for treatment. Methods: In multicenter retrospective cohort study, 670 3279 from MR CLEAN...
Computed tomography perfusion (CTP) is variably considered to assess eligibility for endovascular thrombectomy (EVT) in acute ischemic (AIS) stroke patients. Although CTP recommended patient selection later (6-24 h) time window, it currently not the earlier (0-6 window and costs health effects of including EVT remain unknown. We aim estimate using AIS patients compared conventional selection.CLEOPATRA a healthcare evaluation study clinical imaging data from multiple, prospective trials...
CT perfusion imaging is important in the workup of acute ischemic stroke for evaluating affected cerebral tissue. analysis software produces maps from commonly noisy spatio-temporal data. High levels noise can influence results analysis, necessitating tuning. This work proposes a novel approach that uses physics-informed learning, an optimization framework robust to noise. In particular, we propose SPPINN: Spatio-temporal Perfusion Physics-Informed Neural Network and research learning....
(1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-consuming subject to inter-observer bias. Alternatively, a recently introduced fully automated deep learning-based algorithm can be used consistently estimate full characteristics. Here, we exploratively assess value novel biomarkers in terms their...
Abstract Objectives CT perfusion (CTP) has been suggested to increase the rate of large vessel occlusion (LVO) detection in patients suspected acute ischemic stroke (AIS) if used addition a standard diagnostic imaging regime angiography (CTA) and non-contrast (NCCT). The aim this study was estimate costs health effects additional CTP for endovascular treatment (EVT)–eligible using model-based analyses. Methods In Dutch, nationwide retrospective cohort with economic evaluation, data from 701...
To compare single parameter thresholding with multivariable probabilistic classification of ischemic stroke regions in the analysis computed tomography perfusion (CTP) maps.Patients were included from two multicenter trials and divided into groups based on their modified arterial occlusive lesion grade. CTP maps generated three methods-a commercial method (ISP), block-circulant singular value decomposition (bSVD), non-linear regression (NLR). Follow-up non-contrast CT defined follow-up...
Background The effects of thrombus imaging characteristics on procedural and clinical outcomes after ischemic stroke are increasingly being studied. These – for eg, size, location, density commonly analyzed as separate entities. However, it is known that some these strongly related. Multicollinearity can lead to unreliable prediction models. We aimed determine the distribution, correlation clustering based a large dataset anterior-circulation acute patients. Methods measured in MR CLEAN...
Computed tomography perfusion (CTP) is frequently performed during the diagnostic workup of acute ischemic stroke patients. Yet, core estimates vary widely between different commercially available software packages. We assessed volumetric and spatial agreement on CTP with follow-up infarct diffusion-weighted imaging (DWI) using an automated software.
Intravenous alteplase (IVT) prior to endovascular treatment (EVT) is neither superior nor noninferior EVT alone in acute ischemic stroke patients. We aim assess whether the effect of IVT differs according CT perfusion (CTP)-based imaging parameters.In this retrospective post hoc analysis, we included patients from MR CLEAN-NO IV with available CTP data. data were processed using syngo.via (version VB40). performed multivariable logistic regression obtain size estimates (adjusted common odds...
We aimed to evaluate the real-world variation in CT perfusion (CTP) imaging protocols among stroke centers and explore potential for standardizing vendor software harmonize CTP images.
We aimed to study the association of non-contrast CT (NCCT) thrombus density with procedural and clinical outcomes in patients acute ischemic stroke who underwent endovascular treatment (EVT). Since is associated location, we focused on M1 occlusions only.Patients available thin-slice (< 2.5 mm) NCCT were included from a nationwide registry. Regression models used assess relation between (per Hounsfield unit [HU]) following outcomes. For reperfusion grade, adjusted common odds ratios (acOR)...
Abstract Background CT perfusion (CTP) has been suggested to increase the rate of large vessel occlusion (LVO) detection in patients suspected acute ischemic stroke (AIS) if used addition a standard diagnostic imaging regime angiography (CTA) and non-contrast (NCCT). The aim this study was estimate costs health effects additional CTP for endovascular treatment (EVT)-eligible using model-based analyses. Methods In Dutch, nationwide retrospective cohort with economic evaluation, data from 701...