Rick van Nuland
A5050767793- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Cerebrovascular and Carotid Artery Diseases
- Artificial Intelligence in Healthcare and Education
- Neuroendocrine Tumor Research Advances
- Venous Thromboembolism Diagnosis and Management
- Ethics in Clinical Research
- Economic and Financial Impacts of Cancer
- Peripheral Artery Disease Management
- Clinical practice guidelines implementation
- HIV Research and Treatment
- Privacy-Preserving Technologies in Data
- Health Systems, Economic Evaluations, Quality of Life
- Trypanosoma species research and implications
- Research Data Management Practices
- Intracerebral and Subarachnoid Hemorrhage Research
- Endoplasmic Reticulum Stress and Disease
- ATP Synthase and ATPases Research
- Research on Leishmaniasis Studies
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
- Artificial Intelligence in Healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
Lygature
2024-2025
Stanford University
2015
Utrecht University
2013
University Medical Center Utrecht
2009-2013
Netherlands Metabolomics Centre
2013
Vrije Universiteit Amsterdam
2010
Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) complexes that contain methyltransferase activity for H3K4 have been described, but a comprehensive and quantitative analysis these SET1/MLL lacking. We applied label-free mass spectrometry determine the subunit composition stoichiometry complexes. identified both known novel, unique shared interactors determined...
Recognition of histone modifications by specialized protein domains is a key step in the regulation DNA-mediated processes like gene transcription. The structural basis these interactions usually studied using peptide models, neglecting nucleosomal context. Here, we provide and thermodynamic for recognition H3K36-methylated (H3K36me) nucleosomes PSIP1-PWWP domain, based on extensive mutational analysis, advanced nuclear magnetic resonance (NMR), computational approaches.The domain binds...
The adoption of the European Health Data Space (EHDS) regulation has made integrating health data critical for both primary and secondary applications. Primary use cases include patient diagnosis, prognosis, treatment, while applications support research, innovation, regulatory decision-making. Additionally, leveraging large datasets improves training quality artificial intelligence (AI) models, particularly in cancer prevention, prediction, treatment personalization. Union (EU) recently...
We are creating a synergy among European Health Data Space projects (e.g., IDERHA, EUCAIM, ASCAPE, iHELP, Bigpicture, and HealthData@EU pilot project) via health standards usage thanks to the HSBOOSTER EU Project since they involved or using standards, and/or designing ontologies. compare health-standardized models/ontologies/terminologies such as HL7 FHIR, DICOM, OMOP, ISO TC 215 Informatics, W3C DCAT, etc. used in those projects.
Summary Awareness is growing that drug target validation should involve systems analysis of cellular networks. There less appreciation, though, the composition networks may change in response to drugs. If homeostatic (e.g. through upregulation protein), this neutralize inhibitory effect. In scenario effect on cell growth and survival would be than anticipated based affinity for its target. Glycolysis sole free‐energy source deadly parasite Trypanosoma brucei therefore a possible pathway...
Abstract Background Despite evidence of a quite large beneficial effect endovascular treatment (EVT) for ischemic stroke caused by anterior circulation vessel occlusion, many patients do not recover even after complete recanalization. To some extent, this may be attributable to incomplete microvascular reperfusion, which can possibly improved antiplatelet agents and heparin. It is unknown whether periprocedural antithrombotic medication in treated with EVT improves functional outcome. The...
Abstract Biomedical data are generated and collected from various sources, including medical imaging, laboratory tests genome sequencing. Sharing these for research can help address unmet health needs, contribute to scientific breakthroughs, accelerate the development of more effective treatments inform public policy. Due potential sensitivity such data, however, privacy concerns have led policies that restrict sharing. In addition, sharing sensitive requires a secure robust infrastructure...
The process of eukaryotic transcription initiation involves the assembly basal factor complexes on gene promoter. recruitment TFIID is an early and important step in this process. Gene promoters contain distinct DNA sequence elements are marked by presence post-translationally modified nucleosomes. contributions these individual features for remain to be elucidated. Here, we use immobilized reconstituted promoter nucleosomes, conventional biochemistry quantitative mass spectrometry...
Background: We aimed to assess whether the effect of intravenous alteplase treatment (IVT) before endovascular (EVT) on outcome is modified by first-line technique during EVT in IVT eligible patients. Methods: This was a post hoc analysis from MR CLEAN-NO IV (Multicenter Randomized Clinical Trial Endovascular Treatment for Acute Ischemic Stroke Netherlands - Intravenous Followed Intra-Arterial Versus Direct Caused Proximal Intracranial Occlusion), randomized trial followed versus alone...
Abstract Objectives CT perfusion (CTP) has been suggested to increase the rate of large vessel occlusion (LVO) detection in patients suspected acute ischemic stroke (AIS) if used addition a standard diagnostic imaging regime angiography (CTA) and non-contrast (NCCT). The aim this study was estimate costs health effects additional CTP for endovascular treatment (EVT)–eligible using model-based analyses. Methods In Dutch, nationwide retrospective cohort with economic evaluation, data from 701...
<sec> <title>UNSTRUCTURED</title> The adoption of the European Health Data Space (EHDS) regulation has made integrating health data critical for both primary and secondary applications. Primary use cases include patient diagnosis, prognosis, treatment, while applications support research, innovation, regulatory decision-making. Additionally, leveraging large datasets improves training quality artificial intelligence (AI) models, particularly in cancer prevention, prediction, treatment...