A5062782405- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- HVDC Systems and Fault Protection
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Plant Molecular Biology Research
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
The Francis Crick Institute
2021-2022
University Medical Center Utrecht
2007-2016
Jawaharlal Nehru Centre for Advanced Scientific Research
2004-2009
Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation gene expression eukaryotes all viral DNA that integrates into human genome (e.g. immunodeficiency virus). Dysfunction histone acetyltransferases (HATs) often associated with manifestation several diseases. In this respect, HATs are new potential targets for design therapeutics. study, we report curcumin (diferuloylmethane), a major curcumanoid spice turmeric, specific...
Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper recruitment and function histone acetyltransferases (HATs) deacetylases (HDACs) are key regulatory steps for gene expression cell cycle. Functional defects either these enzymes may lead to several diseases, including cancer. HATs HDACs thus potential therapeutic targets. Here we report that garcinol, polyisoprenylated benzophenone derivative from Garcinia indica fruit rind, potent inhibitor p300 (IC50...
methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function
Methylation of the arginine residues histones by methyltransferases has important consequences for chromatin structure and gene regulation; however, molecular mechanism(s) methyltransferase regulation is still unclear, as biological significance methylation at particular residues. Here, we report a novel specific inhibitor coactivator-associated 1 (CARM1; also known PRMT4) that selectively inhibits 17 histone H3 (H3R17). Remarkably, this plant-derived inhibitor, called TBBD (ellagic acid),...
Menin, the product of MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, is involved in activation gene transcription as part an MLL1 (mixed-lineage leukemia 1)/MLL2 (KMT2A/B)-containing protein complex which harbors methyltransferase activity for lysine 4 histone H3 (H3K4). As patients frequently develop lipomas and peroxisome proliferator-activated receptor gamma (PPARgamma) expressed several MEN1-related types, we investigated regulation PPARgamma by menin. We found that...
Abstract N6- methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function Saccharomyces cerevisiae , occurs solely during early meiosis. Here we perform a multifaceted analysis of the protein Pho92/Mrb1. Cross-linking immunoprecipitation reveals that Pho92 associates with 3’end meiotic mRNAs both an m6A-dependent independent manner. Within cells, transitions from...