A5031386833- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Medical Image Segmentation Techniques
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Stroke Rehabilitation and Recovery
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroblastoma Research and Treatments
- S100 Proteins and Annexins
- Neuropeptides and Animal Physiology
- Multiple Sclerosis Research Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Microbial Inactivation Methods
- Ultrasound and Hyperthermia Applications
Massachusetts General Hospital
2023-2025
The University of Adelaide
2017-2025
University College London
2025
Athinoula A. Martinos Center for Biomedical Imaging
2024-2025
Harvard University
2023-2025
Massachusetts Institute of Technology
2025
Yale University
2025
Neurology, Inc
2025
MRC Mitochondrial Biology Unit
2022-2024
University of Cambridge
2020-2024
Early stroke detection and treatment are critical for improving patient outcomes. Optical brain pulse monitoring (OBPM) uses red infrared light to capture waveforms reflecting arteriole-to-venous pressure levels driving microvascular blood flow. This study assessed OBPMs potential detect middle cerebral artery occlusion (MCAo) reperfusion in a clinically relevant sheep model. Stroke was induced 11 Merino wethers via 4-hour of the right MCA, followed by 6 hours reperfusion. OBPM recordings...
Neuroimaging is essential for detecting spontaneous, nontraumatic intracerebral hemorrhage (ICH). Recent data suggest ICH can be characterized using low-field magnetic resonance imaging (MRI). Our primary objective was to investigate the sensitivity and specificity of on a 0.064T portable MRI (pMRI) scanner methodology that provided clinical information inform rater interpretations. As secondary aim, we investigated whether incorporation deep learning (DL) reconstruction algorithm affected detection.
Ischaemia-reperfusion (IR) injury is the paradoxical consequence of rapid restoration blood flow to an ischaemic organ. Although reperfusion essential for tissue survival in conditions such as myocardial infarction and stroke, excessive production mitochondrial reactive oxygen species (ROS) upon initiates oxidative damage that underlies IR injury, by causing cell death inflammation. This ROS caused accumulation metabolite succinate during ischaemia, followed its oxidation dehydrogenase...
Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine inhibitors (ALK TKI) distinct possibility necessitating drug combination approaches. Using high-throughput, genome-wide CRISPR-Cas9 knockout screens, we identify miR-1304-5p loss as desensitizer TKIs in neuroblastoma; inhibition of decreases, while mimics this miRNA increase the sensitivity neuroblastoma cells TKIs. We...
Objective For stroke patients with unknown time of onset, mismatch between diffusion‐weighted imaging (DWI) and fluid‐attenuated inversion recovery (FLAIR) magnetic resonance (MRI) can guide thrombolytic intervention. However, access to MRI for hyperacute is limited. Here, we sought evaluate whether a portable, low‐field (LF)‐MRI scanner identify DWI‐FLAIR in acute ischemic stroke. Methods Eligible diagnosis underwent LF‐MRI acquisition on 0.064‐T within 24 h last known well. Qualitative...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Portable MRI (pMRI) has emerged as a cost-effective and accessible tool for the identification of white matter hyperintensities (WMH), an independent risk factor stroke dementia. Our objective was to confirm that pMRI can produce accurate WMH measurements develop validate model predict on purpose identifying patients who may benefit from screening. <h3>MATERIALS METHODS:</h3> The development (N=143) validation (N=127) cohorts included...
Introduction: Education campaigns have previously successfully informed the public regarding stroke symptoms and need for urgent evaluation of suspected stroke. However, not all patients with strokes requiring intervention present to hospital by ambulance, which would usually be fastest means reach a hospital. The aims this study were characterize cohort an acute ischemic that require reperfusion therapy who emergency department without engaging ambulance services. Methods: A multicentre...
Introduction: Portable, low-field (LF) magnetic resonance imaging (MRI) has the potential to improve access brain and facilitate diagnosis of acute ischemic stroke (AIS). However, due longer acquisition time, diffusion-weighted (DWI) at LF is often restricted a single diffusion direction, which may reduce sensitivity detection. We developed multi-direction DWI sequence evaluated its ability detect lesions compared with single-direction sequence. Methods: Patients suspected AIS were...
Introduction: The use of ultra low-field portable Magnetic Resonance Imaging (pMRI) in acute ischemic stroke (AIS) is gaining interest, as pMRI FDA approved and has practical advantages over high-field MRI brain (hMRI). ACTION PMR study a prospective cohort enrolling AIS perform within 24 hours last known normal (LKN). We sought to report patients enrolled the from our institution evaluate performance compared hMRI. Methods: Among 10 center, 1 was excluded for technically nondiagnostic...
Female patients with AIS may not receive thrombolytic equitably. We examined whether there were sex differences in the likelihood of receiving South Australian patients. In a retrospective cohort study, consecutive admitted to metropolitan stroke units within Australia between January 2019 December 2023 without contraindication included. Multivariable logistic regression was used determine relevance demographic, clinical, imaging and service delivery parameters associated intravenous...
Brainstem white matter bundles are essential conduits for neural signaling involved in modulation of vital functions ranging from homeostasis to human consciousness. Their architecture forms the anatomic basis brainstem connectomics, subcortical mesoscale circuit models, and deep brain navigation tools. However, their small size complex morphology compared cerebral structures makes mapping segmentation challenging neuroimaging. This results a near absence automated tracing methods. We...
Background and Purpose: Cerebral edema elevated intracranial pressure (ICP) are the leading cause of death in first week following stroke. Despite this, current treatments limited fail to address underlying mechanisms swelling, highlighting need for targeted treatments. When screening promising novel agents, it is essential use clinically-relevant large animal models increase likelihood successful clinical translation. As such, we sought develop a survival model transient middle cerebral...
Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), administration of an NK1-R antagonist shown to ameliorate BBB dysfunction edema in rodent permanent ovine stroke models. Given importance reperfusion clinical this study examined efficacy treatment reducing ICP...
Background and Purpose: The morbidity early mortality associated with stroke is largely attributable to cerebral edema elevated intracranial pressure (ICP). Existing pharmacotherapies do not target the underlying pathophysiology are often ineffective in sustainably lowering ICP, whilst decompressive craniectomy (DC) surgery life-saving yet surgical/peri-operative risk increased elderly. Accordingly, there an urgent need for therapies that directly mechanisms of genesis. Neurogenic...
Brain atrophy and white matter hyperintensity (WMH) are critical neuroimaging features for ascertaining brain injury in cerebrovascular disease multiple sclerosis. Automated segmentation quantification is desirable but existing methods require high-resolution MRI with good signal-to-noise ratio (SNR). This precludes application to clinical low-field portable (pMRI) scans, thus hampering large-scale tracking of WMH progression, especially underserved areas where pMRI has huge potential. Here...